Osteoclast-type giant cell tumor of the pancreas: helical CT scans.

Shindoh, Noboru; Ozaki, Yuka; Kyogoku, Shinsuke; Nakanishi, Ataru; Sumi, Yukiharu; Katayama, Hironori

doi:10.2214/ajr.170.3.9490947

Cited by 16 publications

(6 citation statements)

References 3 publications

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“…On imaging work-up, UC-OGC appears larger than pancreatic ductal adenocarcinoma and generally displays a cystic component ( 14 ). Bile duct dilatation, pancreatic duct dilatation and necrotic areas are common findings ( 54 , 55 ). Calcification ( 56 ), hemorrhage ( 56 , 57 ), and venous tumor thrombus ( 57 ) have also been described.…”

Section: Diagnosismentioning

confidence: 99%

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

et al. 2021

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Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC.

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Section: Diagnosismentioning

confidence: 99%

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

et al. 2021

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“…In contrast to T1 hypointense lesions usually demonstrated in pancreas metastases from other primary cancers, melanoma has a typical high signal intensity on T1 weighted images due to melanin and iron secondary to hemorrhage with paramagnetic T1 shortening effect (7)(8)(9). About 50% of melanomas show high signal intensity on T1 weighted images but this finding is rare in other malignancies (10). Non-tumorous, bland thrombus can be shown as high signal intensity on T1 weighted images, but in this case, intense 18F-FDG uptake in thrombi was clearly visible on PET and the diagnosis of tumor thrombus by malignant melanoma could be made.…”

Section: Discussionmentioning

confidence: 95%

Metastatic Melanoma to the Pancreas Forming Portal Vein Tumor Thrombosis: A Case Report

Kim

Choi

et al. 2016

Iran J Radiol

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Pancreatic metastasis of malignant melanoma is rare and porto-splenic tumor thrombus associated with malignant melanoma is even less frequent. We report a case of metastatic malignant melanoma involving the pancreas, portal vein, splenic vein and superior mesenteric vein. A 60-year-old man showed an elevated amylase level. He had a history of sigmoid colon adenocarcinoma and malignant melanoma. Computed tomography (CT) and magnetic resonance imaging (MRI) showed extensive thrombosis involving the intra-and extrahepatic portal veins extending into the superior/inferior mesenteric vein and splenic vein. On T1 weighted images, tumor thrombi demonstrated diffusely high signal intensity, which is a characteristic finding in malignant melanoma. Also, thrombus showed prominent diffusion restriction on diffusion weighted images and intense uptake of 18F-fluorodeoxyglucose (18F-FDG) on positron emission tomography (PET). Ultrasound-guided biopsy confirmed the metastatic, malignant melanoma involving the pancreas and the veins. We report an unusual manifestation of metastatic, malignant melanoma to the pancreas with extensive tumor thrombi. Specific MR features including high signal intensity on T1 weighted images and diffusion restriction on diffusion weighted images were helpful in reaching a conclusion.

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“…Few case reports and series have been reported mainly focusing on pancreatic UCOGC, in which a larger tumor size containing a cystic component was noticed compared with conventional pancreatic ductal adenocarcinoma [ 20 ]. Additionally, dilatation of the bile duct and pancreatic duct along with the presence of necrotic areas were commonly observed [ 21 , 22 ]. Occasional calcification, hemorrhage and venous tumor thrombus had also been recorded [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Common Bile Duct: A Case Report of a Rare Entity at an Unusual Location

Chen

2022

Diagnostics

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Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) is a rare variant of carcinoma with unique radiological and pathological features. This unusual carcinoma has been reported in a variety of organs and pancreas is the most frequently involved anatomical site. UCOGC of pancreas attains a relatively indolent clinical behavior and should be distinguished from ordinary pancreatobiliary adenocarcinoma. This paper presents the first case of UCOGC involving the entire segment of common bile duct (CBD) and common hepatic duct (CHD) without extending to the pancreatic tissue. Getting familiar with its clinical, radiological and pathological characters can help establish accurate diagnosis despite the occurrence of an unusual location.

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Osteoclast-type giant cell tumor of the pancreas: helical CT scans.

Cited by 16 publications

References 3 publications

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

Metastatic Melanoma to the Pancreas Forming Portal Vein Tumor Thrombosis: A Case Report

Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Common Bile Duct: A Case Report of a Rare Entity at an Unusual Location

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