Osteochondral Autologous Transplantation

Sherman, Seth L.; Thyssen, Emil; Nuelle, Clayton W.

doi:10.1016/j.csm.2017.02.006

Cited by 51 publications

(31 citation statements)

References 22 publications

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“…This treatment, along with the matrix induced autologous chondrocyte implantation (MACI) method [233], has shown positive clinical results for larger cartilage defects [234,235]. However, each method has its own limitations that have been previously discussed to great lengths [236][237][238][239][240].…”

Section: Stimulating Articular Cartilage Repairmentioning

confidence: 99%

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair

Desai

Jayasuriya

2020

Bioengineering

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Harnessing adult mesenchymal stem/progenitor cells to stimulate skeletal tissue repair is a strategy that is being actively investigated. While scientists continue to develop creative and thoughtful ways to utilize these cells for tissue repair, the vast majority of these methodologies can ultimately be categorized into two main approaches: (1) Facilitating the recruitment of endogenous host cells to the injury site; and (2) physically administering into the injury site cells themselves, exogenously, either by autologous or allogeneic implantation. The aim of this paper is to comprehensively review recent key literature on the use of these two approaches in stimulating healing and repair of different skeletal tissues. As expected, each of the two strategies have their own advantages and limitations (which we describe), especially when considering the diverse microenvironments of different skeletal tissues like bone, tendon/ligament, and cartilage/fibrocartilage. This paper also discusses stem/progenitor cells commonly used for repairing different skeletal tissues, and it lists ongoing clinical trials that have risen from the implementation of these cells and strategies. Lastly, we discuss our own thoughts on where the field is headed in the near future.

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Section: Stimulating Articular Cartilage Repairmentioning

confidence: 99%

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair

Desai

Jayasuriya

2020

Bioengineering

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“…In the clinic, surgical treatment is the most common strategy for the treatment of osteochondral defects (W. Zhang et al, 2010). Overall, there are over 2.2 million surgical therapies associated with osteochondral tissue repair annually (Giannoudis, Dinopoulos, & Tsiridis, 2005;Sherman, Thyssen, & Nuelle, 2017). Based on the treatment process, the surgical treatment can be divided into palliative treatment, reparative treatment, and restorative treatment ( Figure 2).…”

Section: The Challenges and Current Strategies For Regeneration Of mentioning

confidence: 99%

Advances of nanotechnology in osteochondral regeneration

Deng

Zhou

et al. 2019

WIREs Nanomed Nanobiotechnol

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In the past few decades, nanotechnology has proven to be one of the most powerful engineering strategies. The nanotechnologies for osteochondral tissue engineering aim to restore the anatomical structures and physiological functions of cartilage, subchondral bone, and osteochondral interface. As subchondral bone and articular cartilage have different anatomical structures and the physiological functions, complete healing of osteochondral defects remains a great challenge. Considering the limitation of articular cartilage to self‐healing and the complexity of osteochondral tissue, osteochondral defects are in urgently need for new therapeutic strategies. This review article will concentrate on the most recent advancements of nanotechnologies, which facilitates chondrogenic and osteogenic differentiation for osteochondral regeneration. Moreover, this review will also discuss the current strategies and physiological challenges for the regeneration of osteochondral tissue. Specifically, we will summarize the latest developments of nanobased scaffolds for simultaneously regenerating subchondral bone and articular cartilage tissues. Additionally, perspectives of nanotechnology in osteochondral tissue engineering will be highlighted. This review article provides a comprehensive summary of the latest trends in cartilage and subchondral bone regeneration, paving the way for nanotechnologies in osteochondral tissue engineering. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement

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“…Osteochondral autograft transplantation is a single stage approach in which defects are filled with autologous osteochondral plugs, leading to the formation of homogenous tissue. The disadvantages of this technique include donor-site morbidity, technical difficulties in matching the lesion contour, defect size, and the risk of cartilage and bone collapse [6,7]. In past decades, autologous chondrocyte implantation (ACI) emerged as a suitable technique that might yield hyaline-like regenerative tissues that would have better histological, mechanical, and clinical results than stimulation through microfracture [8,9].…”

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Fibrin Facilitates One-Stage Cartilage Repair by Promoting Chondrocytes Viability, Migration, and Matrix Synthesis

Wong

Lin

et al. 2020

IJMS

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The main aim of this study is to develop a one-stage method to combine platelet-rich fibrin (PRF) and autologous cartilage autografts for porcine articular cartilage repair. The porcine chondrocytes were treated with different concentrations of PRF-conditioned media and were evaluated for their cell viability and extracellular glycosaminoglycan (GAG) synthesis during six day cultivation. The chemotactic effects of PRF on chondrocytes on undigested cartilage autografts were revealed in explant cultures. For the in vivo part, porcine chondral defects were created at the medial femoral condyles of which were (1) left untreated, (2) implanted with PRF combined with hand-diced cartilage grafts, or (3) implanted with PRF combined with device-diced cartilage grafts. After six months, gross grades, histological, and immunohistochemical analyses were compared. The results showed that PRF promotes the viability and GAG expression of the cultured chondrocytes. Additionally, the PRF-conditioned media induce significant cellular migration and outgrowth of chondrocytes from undigested cartilage grafts. In the in vivo study, gross grading and histological scores showed significantly better outcomes in the treatment groups as compared with controls. Moreover, both treatment groups showed significantly more type II collagen staining and minimal type I collagen staining as compared with controls, indicating more hyaline-like cartilage and less fibrous tissue. In conclusion, PRF enhances the viability, differentiation, and migration of chondrocytes, thus, showing an appealing capacity for cartilage repair. The data altogether provide evidences to confirm the feasibility of a one-stage, culture-free method of combining PRF and cartilage autografts for repairing articular cartilage defects. From translational standpoints, these advantages benefit clinical applications by simplifying and potentiating the efficacy of cartilage autograft transplants.

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Osteochondral Autologous Transplantation

Cited by 51 publications

References 22 publications

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair

Advances of nanotechnology in osteochondral regeneration

Platelet-Rich Fibrin Facilitates One-Stage Cartilage Repair by Promoting Chondrocytes Viability, Migration, and Matrix Synthesis

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