Osteochondral autologous transplantation in various joints

Imhoff, Andreas B.; Öttl, G.; Burkart, Andreas; Traub, Shaun

doi:10.1007/pl00003547

Cited by 43 publications

(29 citation statements)

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“…Several independent evaluations have described similar results, suggesting that, when a well-standardized technique is followed and when the indications are the same as those used in our studies, the results are reproducible. 5,16,29,31,58,59,74,76,79,84,89,91 Appropriate treatment of the underlying causes of the cartilage lesion has an essential role in the success of any cartilage repair method. The nature of the mosaicplasty is such that other corrective operations and accompanying rehabilitation protocols can be easily integrated.…”

Section: Discussionmentioning

confidence: 99%

“…8,9,32,36,38,39,45 During the following years, the clinical results reported by various authors matched the results seen in animals, and since 1995 the procedure has been used with equal success in numerous institutions throughout the world. 5,16,40,55,57,58,59,61,63,71,72,74,84,88,91 …”

Section: Findings In Animal Studiesmentioning

confidence: 99%

“…Donor-site repair by natural healing processes should result in filling of the tunnels with cancellous bone and coverage of the surface with reparative fibrocartilage. 32,[39][40][41][42]45,47,57,58,59,61,68,72,74,81,88,89,91,92 …”

Section: Outline Of the Techniquementioning

confidence: 99%

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Autologous Osteochondral Mosaicplasty Grafting

Bartha

Vajda

Duska

et al. 2006

J Orthop Sports Phys Ther

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Successful management of chondral and osteochondral defects of the weight-bearing joint surfaces has always been a challenge for orthopedic surgeons and rehabilitation specialists. Autologous osteochondral mosaic transplantation technique is one of the recently evolved methods to create hyaline or hyaline-like repair tissue in the pathologic area. Clinical evaluation, various imaging techniques, arthroscopy (second look), histological examination of biopsy samples, and measurements of cartilage mechanical properties are used to evaluate the merits of outcomes and quality of the transplanted cartilage. According to our investigations, good to excellent results were achieved in more than 92% of patients treated with femoral condylar implantations, 87% of those treated with tibial resurfacing, 79% of those treated with patellar and/or trochlear mosaicplasties, and 94% of those treated with talar procedures. Long-term donor-site discrepancies, assessed with use of the Bandi Score, showed that patients had 3% morbidity after mosaicplasty. Sixty-nine of 89 patients who were followed up with a second-look arthroscopy showed congruent gliding surfaces, histological evidence of the survival of the transplanted hyaline cartilage, and fibrocartilage filling of the donor sites. In a series of 831 consecutive patients, very few complications have been observed. These included 4 deep infections and 36 painful postoperative intra-articular bleedings. On the basis of these results and those of other similar studies, autologous osteochondral mosaicplasty appears to be a promising alternative for the treatment of small-and medium-sized focal chondral and osteochondral defects of the weight-bearing surfaces of the knee and other weight-bearing synovial joints.

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Section: Discussionmentioning

confidence: 99%

Section: Findings In Animal Studiesmentioning

confidence: 99%

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Autologous Osteochondral Mosaicplasty Grafting

Bartha

Vajda

Duska

et al. 2006

J Orthop Sports Phys Ther

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“…Plugs that are too low may be disposed to late degradation [11]. Inaccurate placement of the plugs or malrotation of the plugs can prevent the reconstruction of the natural articular curvature [7].…”

Section: Introductionmentioning

confidence: 99%

Computer-assisted mosaic arthroplasty using patient-specific instrument guides

Kunz

Waldman

Rudan

et al. 2011

Knee Surg Sports Traumatol Arthrosc

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“…The transplantation of autologous osteochondral grafts has shown promising results in the treatment of circumscribed cartilage lesions [10][11][12][13][14][15]. Therefore, autologous cylindrical osteochondral grafts are taken from the minimal weightbearing periphery of the lateral or medial femoral condyle at the level of the patellofemoral joint and are transplanted to prepared defect sites on the weight-bearing surfaces.…”

Section: Osteochondral Autologous Transplantation (Eg Oats Tm )mentioning

confidence: 99%

Injuries to the Articular Cartilage

Vogt

Imhoff

2006

Eur J Trauma

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Injuries to articular cartilage are commonly encountered in orthopedic sports medicine. These lesions can lead to sport invalidity and premature osteoarthritis. The management of chondral and osteochondral lesions represents a challenge to clinicians and scientists. The aim of the therapy has to be the recurrence to former sport levels and the prevention of early osteoarthritis. Today there are different concepts of treatment. One therapy principle is the recruitment of mesenchymal stem cells. These procedures lead at best to fibrocartilaginous repair tissue that is functionally inferior to normal hyaline cartilage. Another group of procedures is the transplantation of autologous osteochondral grafts, which provide repair with a hyaline cartilage matrix and show good clinical medium-term results. But osteochondral grafts are limited and there is a potential donor-site morbidity. Finally, the transplantation of autologous chondrocytes is used. However, this kind of transplantation repairs the chondral injury only by fibrocartilaginous repair tissue, too. Therefore, new techniques for the treatment of articular cartilage injuries have to be established. The most promising field today is the combination of tissue-engineering and gene therapeutic methods for the treatment of the chondral and osteochondral lesions.

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Osteochondral autologous transplantation in various joints

Cited by 43 publications

References 0 publications

Autologous Osteochondral Mosaicplasty Grafting

Autologous Osteochondral Mosaicplasty Grafting

Computer-assisted mosaic arthroplasty using patient-specific instrument guides

Injuries to the Articular Cartilage

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