Osteochondral Allograft Transplantation

Bugbee, William D.; Fr, Convery

doi:10.1016/s0278-5919(05)70130-7

Cited by 267 publications

(138 citation statements)

References 12 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…Potential allograft donor sources for defects within the acetabular side of the hip were a cadaveric acetabulum or medial tibial plateau. Cartilage is relatively immunoprivileged and avascular; thus, the host immune reaction is considered to be limited [38]. Allograft bone becomes necrotic and is reabsorbed via creeping substitution during the healing process.…”

Section: Osteochondral Allograft Transplantationmentioning

confidence: 99%

Outcomes of cartilage repair techniques for chondral injury in the hip—a systematic review

Nakano

Gohal

Duong

et al. 2018

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Objective/purpose The aim of the study was to assess the options of treatment and their related outcomes for chondral injuries in the hip based on the available evidence whilst highlighting new and innovative techniques. Methods A systematic review of the literature from PubMed (Medline), EMBASE, Google Scholar, British Nursing Index (BNI), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Allied and Complementary Medicine Database (AMED) was undertaken from their inception to March 2017 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Clinical outcome studies, prospective/retrospective case series and case reports that described the outcome of cartilage repair technique for the chondral injury in the hip were included. Studies on total hip replacement, animal studies, basic studies, trial protocols and review articles were excluded. Results The systematic review found 21 relevant papers with 596 hips. Over 80% of the included studies were published in or after 2010. Most studies were case series or case reports (18 studies, 85.7%). Arthroscopy was used in 11 studies (52.4%). The minimum follow-up period was six months. Mean age of the participants was 37.2 years; 93.5% of patients had cartilage injuries of the acetabulum and 6.5% of them had injuries of the femoral head. Amongst the 11 techniques described in the systematic review, autologous matrix-induced chondrogenesis, osteochondral autograft transplantation and microfracture were the three frequently reported techniques. Conclusion Over ten different techniques are available for cartilage repair in the hip, and most of them have good short-to medium-term outcomes. However, there are no robust comparative studies to assess superiority of one technique over another, and further research is required in this arena.

show abstract

Section: Osteochondral Allograft Transplantationmentioning

confidence: 99%

Outcomes of cartilage repair techniques for chondral injury in the hip—a systematic review

Nakano

Gohal

Duong

et al. 2018

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

“…Most cartilage repair techniques were introduced to treat lesions in the knee. These include arthroscopic débridement [32], bone marrow stimulation [21,32,52,58], chondrocyte implantation [8], and autograft [26] or allograft transplantation [9]. Secondgeneration techniques combine the use of scaffolds with bone marrow stimulation or chondrocyte implantation.…”

Section: Introductionmentioning

confidence: 99%

Surgical Technique: Second-generation Bone Marrow Stimulation via Surgical Dislocation to Treat Hip Cartilage Lesions

Leunig

Tibor

Naal

et al. 2012

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…The process of introducing and securing transplanted cells within the defect site may be simplified by the use of preformed, cell-laden tissues. Although used infrequently, osteochondral allografts, with fully formed and mature articular cartilage, have a long history of clinical success [3,9] and, as a consequence, autologous osteochondral grafts are now being studied [21]. Other chondrogenic tissues, such as periosteum [34] and perichondrium [6], have also been implanted with the goal of promoting the differentiation of chondrogenic cells within the tissue into chondrocytes capable of producing a cartilage matrix.…”

Section: Introductionmentioning

confidence: 99%

A novel two‐step method for the formation of tissue‐engineered cartilage by mature bovine chondrocytes: The alginate‐recovered‐chondrocyte (ARC) method

Masuda¹,

Sah

Hejna

et al. 2003

Journal Orthopaedic Research

241

185

View full text Add to dashboard Cite

Most attempts to tissue-engineer cartilage have involved seeding of cultured cells into a biological or synthetic scaffold. We have developed a novel two-step culture approach that makes possible the in vitro formation of cartilaginous-like tissue by mature adult bovine chondrocytes without the aid of a synthetic matrix. The first step consists of culturing chondrocytes under conditions that maintain their rounded shape and their molecular phenotype as assessed by type I1 collagen and aggrecan production. This step was accomplished by culturing the isolated chondrocytes in alginate beads until the cells have reestablished a proteoglycan-rich cellassociated matrix (CM). The second step consists of culturing the cells with their CM, after recovery from the beads, on a tissue culture insert with a porous membrane. In this study, young adult bovine articular chondrocytes were cultured in alginate beads in the presence of 10% or 20%) fetal bovine serum (FBS). After 7 days of culture, the alginate beads were dissolved by incubating the beads for 20 min in sodium citrate buffer, a calcium chelator. Following a brief centrifugation, the cells with their CM were recovered, resuspended in medium containing 10% or 20% FBS and seeded onto a tissue culture insert. After 1 week of culture on the insert, the individual cells with their CM progressively became incorporated into a mass of cartilaginous tissue. Culture with 20% FBS resulted in the best formation of tissues. These tissues, easily recovered from the insert, were then subjected to biochemical and histological analyses. The biochemical results showed that the chondrocytes remain phenotypically stable in the tissues. The de novo tissue has a relatively high ratio of PGkollagen. Histological examination of the tissue revealed it contained a cartilage-like matrix strongly stained with toluidine blue. This scaffold-free system appears ideal to study, in vitro, the development of transplantable cartilaginous tissue.

show abstract

Osteochondral Allograft Transplantation

Cited by 267 publications

References 12 publications

Outcomes of cartilage repair techniques for chondral injury in the hip—a systematic review

Outcomes of cartilage repair techniques for chondral injury in the hip—a systematic review

Surgical Technique: Second-generation Bone Marrow Stimulation via Surgical Dislocation to Treat Hip Cartilage Lesions

A novel two‐step method for the formation of tissue‐engineered cartilage by mature bovine chondrocytes: The alginate‐recovered‐chondrocyte (ARC) method

Contact Info

Product

Resources

About