Osteocalcin and type 2 diabetes risk in Latinos: A life course approach.

Abstract

OC was inversely associated with T2D risk in Latino adults; however, this pattern was not observed in children.

Serum undercarboxylated osteocalcin correlates with hemoglobin A1c in children with recently diagnosed pediatric diabetes

“…Several clinical reports have shown that higher total OC levels are associated with better glucose homeostasis . Pediatric studies have been conflicting, with some reports that serum OC is inversely associated with the presence of established T2D and inversely correlated with HbA1c while others found an inverse association between total OC and HbA1c as well glucose parameters in adults but not in children . Our study, in children with T1D or T2D, demonstrated that, while cOC was not associated with HbA1c, uOC was.…”

“…5,[8][9][10][11][12] Pediatric studies have been conflicting, with some reports that serum OC is inversely associated with the presence of established T2D and inversely correlated with HbA1c 13 while others found an inverse association between total OC and HbA1c as well glucose parameters in adults but not in children. 14 Our study, in children with T1D or T2D, demonstrated that, while cOC was not associated with HbA1c, uOC was. Our study is the first one to investigate circulating levels of cOC and uOC in the new onset period of pediatric T1D and T2D and report that serum uOC levels are inversely associated with HbA1c 3 months after diagnosis.…”

“…7 The inverse relationship between total OC and glucose homeostasis parameters have been confirmed in adults with pre-diabetes or established type 2 diabetes (T2D). 5,[8][9][10][11][12] However, pediatric studies have been conflicting 13,14 and are lacking in T1D, particularly at the onset of disease. In this study, we examined the relationships between carboxylated OC (cOC) and undercarboxylated OC (uOC) serum concentrations and hemoglobin A1c (HbA1c), serum C-peptide and clinical, and demographic data of pediatric patients with new a diagnosis of T1D or T2D.…”

Complex interplay among adiposity, insulin resistance and bone health

“…It has been suggested that bone insulin resistance may affect whole‐body glucose homeostasis via lower osteocalcin (OC) activity . In one study, glycemia was inversely associated with OC . In a meta‐analysis, OC was associated with HOMA‐β and inversely correlated with HbA1c, fasting plasma glucose, HOMA‐IR, central obesity and the metabolic syndrome .…”

Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases

“…As OC levels appear to be negatively related to age, it is interesting to report that the independent inverse correlation between OC and CV risk parameters, including lipid profile, fasting plasma glucose and insulin, is attenuated or lost in healthy young adults, when adjusted for fat mass or lifestyle factors, such as physical activity [30]. In another study, OC levels were inversely associated with T2DM in Latino adults, but not in children [31], whereas, in obese children, OC was lower and related to insulin resistance and leptin in both cross-sectional and longitudinal analyses [53]. Moreover, serum ucOC was found to be higher in children from families with metabolic syndrome and thus at potential CV risk [25].…”