Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators

Tripathi, Tulika; Gupta, Prahlad; Rai, Priyank; Sharma, Jitender; Gupta, Vinod Kumar; Singh, Navneet

doi:10.1186/s40510-017-0184-y

Cited by 21 publications

(41 citation statements)

References 45 publications

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“…Interestingly, the thickest growth plate cartilage was observed in tibiae of bee pollen supplemented females from meat-PLOS ONE type line, which were characterized by the one of the lowest mechanical strength and mineralization. The deceleration of bone maturation can be associated with the activity of growth factors involved in bone growth such as osteocalcin, insulin-like growth factor I (IGF-I) and steroid hormones [16,21,[47][48][49]. There is a study suggesting that bee pollen can act on bone maturation through modulation of the activity of bone growth factors, as Kolesárová et al [50] report increase in progesterone and estradiol production and decrease in the secretion of IGF-I in female rats after bee pollen supplementation at the dose of 0.5% of feed for 90 days.…”

Section: Plos Onementioning

confidence: 99%

The effect of bee pollen on bone biomechanical strength and trabecular bone histomorphometry in tibia of young Japanese quail (Coturnix japonica)

et al. 2020

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It has been demonstrated in numerous studies that bee pollen supplementation shows numerous positive effects on health. However, its impact on bones is largely unknown. The purpose of this study was to investigate the effect of bee pollen supplementation on the tibia biomechanical properties and bone morphometric measures using Japanese quail as an animal model. The experiment was arranged in a 2x2x2 factorial design, with sex, quail line (meat-type or egg-lying type), and bee pollen inclusion (0 or 10 g/kg of feed) as factors. The quails were one-day-old at the beginning of the experiment, they were euthanized after 42 days. Our study showed for the first time unfavorable effects of bee pollen on bones properties. Bee pollen supplementation negatively affected bone structure, irrespective of quails' sex or line type. Bone length (P < 0.001), weight (P < 0.01), and mean relative wall thickness (P < 0.01) and mineralization (P < 0.05) were reduced by bee pollen treatment. For female quails, irrespective of line type, the decrease of yield load (P < 0.001), ultimate load (P < 0.01), yield stress (P < 0.001) and ultimate stress (P < 0.05) was noted. Analysis of growth plate in bone metaphysis showed that bee pollen supplementation slowed the process of bone maturation irrespective of sex (P < 0.05). On contrary, dietary bee pollen positively affected bone homeostasis of trabecular bone in bone metaphysis as bone mineral density increased in experimental groups (P < 0.05). In males, this was the result of the increase of trabecular thickness (P < 0.01), in females due to the reduction of trabecular space (P < 0.001). In conclusion, our results demonstrate that bee pollen (1.0%, 10 g/kg of feed) supplementation caused significant negative effects on the mechanical endurance of the tibia of quails, while showed beneficial effects on trabecular bone histomorphometry.

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Section: Plos Onementioning

confidence: 99%

The effect of bee pollen on bone biomechanical strength and trabecular bone histomorphometry in tibia of young Japanese quail (Coturnix japonica)

et al. 2020

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“…Anyhow, in our study IGF-1 levels correlated with osteocalcin, suggesting a promoting action on osteoblast production. IGF-1 and OC show parallel patterns in different models in literature [28,29], however, studies about skeletal maturation suggest a triggering action on OC synthesis [30].…”

Section: Discussionmentioning

confidence: 98%

Relationships Between Thyroid Hormones, Insulin-Like Growth Factor-1 and Antioxidant Levels in Hypothalamic Amenorrhea and Impact on Bone Metabolism

et al. 2019

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Supplementary Material for this article is available online at http://www.thieme-connect.de/products ABStR AC tReduced bone mineral density (BMD) in Functional Hypothalamic Amenorrhea (FHA) is mainly related to hypoestrogenism, but other hormonal derangement (reduced conversion of T4-T3 and GH resistance) can play a role. These hormones are involved in antioxidant systems regulation. We evaluated the impact of hormonal alterations, with special focus on low T3 and IGF-1 levels, on antioxidant systems as a link with osteoporosis in FHA. Forty-three FHA patients, 15-34 years, with BMI range 17.3-23.4 kg/m 2 , were divided in 2 groups according to fT3 levels; group A (n = 22), low fT3 ( < 2.4 pg/ml) and group B (n = 21), normal fT3 (≥ 2.4 pg/ml). We evaluated hormonal parameters (fT3, fT4, TSH, IGF-1, FSH, LH, estradiol, DHEAS, testosterone, cortisol), bone metabolism (calcium, phosphorus, 25-OH Vitamin D, PTH, β-crosslaps, bone alkaline phosphatase) and total antioxidant capacity (TAC), expressed as LAG (latency time in radical species appearance using spectrophotometric method). BMD was assessed by DEXA. Group A patients exhibited significantly lower levels of .05 ± 15.25 ng/ml) and osteocalcin (17.51 ± 1.14 vs. 21.49 ± 1.56 ng/ml); LAG values were significantly higher in A (66.33 ± 1.74 s) vs. B (54.62 ± 1.74 s). A significant direct correlation was found between both IGF-1 and fT3 with osteocalcin (r² = 0.22, p = 0.0049 and r² = 0.34, p = 0.0001, respectively). No difference in LAG between groups according to IGF-1 were found. These data show a correlation between altered bone turnover and low fT3, which is highly prevalent in FHA. Low fT3 levels may contribute to reduced BMD. Oxidative stress could be the link underlying different bone turnover pattern and endocrine dysfunction in FHA.

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“…Ezzel szemben az inzulinszerű növekedési faktor-1 (IGF1) termelődését a GH stimulálja, továbbá a GH hatásának elsődleges mediátora -szintje nem fluktuál úgy, mint a GH-é, így sokkal megbízhatóbb módszernek mutatkozik [44]. Számos munkacsoport végzett vizsgálatokat, hogy a szérum-IGF1 (seIGF1) és a radiológiai módszerekkel mért szkeletális korok közötti összefüggésekből következtessenek a növekedés ütemére [44][45][46][47][48]. Ishaq és mtsai szoros korrelációt találtak az egyes csigolyaérettségi stádiumok és a seIGF1 között.…”

Section: Vérminta Vizelet éS Sulcusfolyadék Vizsgálataunclassified

“…Jain és mtsai potenciális lehetőséget látnak ezen kötőfehérjék detektálásában, mivel mennyiségük szoros összefüggést mutatott a csigolyaérettségi stádiumokkal [44]. Tripathi és munkacsoportja osteocalcin [48] és csontspecifikus alkalikus foszfatáz [49] tekintetében talált ígéretes eredményeket, még mások a gingivalis sulcus váladék proteomikai elemzése kapcsán találtak a pubertás alatt szignifikánsan magasabb seroserotransferrin-és D-vitamin-kötő-fehérjeszinteket [50]. Mindezek alapján elmondhatjuk, hogy a szkeletális érettség meghatározása szempontjából a különböző szövetnedvekben jelen lévő biomarkerek még számos kiaknázatlan lehetőséget rejtenek, így nem meglepő, hogy egyre felkapottabb kutatási terültetnek is számítanak.…”

Section: Vérminta Vizelet éS Sulcusfolyadék Vizsgálataunclassified

Klasszikus és modern vizsgálómódszerek a csontérettségi kor és a pubertáskori növekedési csúcs meghatározására

et al. 2018

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The assessment of skeletal age is of utmost importance not only in the field of anthropology, forensic medicine, pediatrics, endocrinology but also in orthodontics and jaw orthopedics. Bone age refers to the individual’s biological development which can differ within a relatively wide range for the same chronological age. Therefore, accurate assessment of skeletal maturity and pubertal growth plays an important role in establishing a diagnosis for certain diseases. In addition, it is essential for proper timing and success of treatments in many cases. Currently, there are many methods available to determine skeletal age and pubertal growth spurt. During growth, bones undergo significant changes, the sequence of which is strongly determined. These changes can be measured by various methods including radiological examinations. More specifically, these classical methods are often based on the radiological evaluation of morphological changes in the hand bones and cervical vertebrae. Methods based on dental development also exist to assess the biologic maturity of an individual. However, thanks to three-dimensional imaging techniques and molecular diagnostic methods, even more accurate tests can be performed to determine biological maturity. These modern methods rely on the information obtained from the cone-beam computer tomograph records and on the measurements of biomarkers present in different circulatory or other body fluids. The purpose of this summary is to provide an overview of the various classical and modern methods for the assessment of skeletal age that could aid us in many fields of science. Orv Hetil. 2018; 159(35): 1423–1432.

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Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators

Cited by 21 publications

References 45 publications

The effect of bee pollen on bone biomechanical strength and trabecular bone histomorphometry in tibia of young Japanese quail (Coturnix japonica)

The effect of bee pollen on bone biomechanical strength and trabecular bone histomorphometry in tibia of young Japanese quail (Coturnix japonica)

Relationships Between Thyroid Hormones, Insulin-Like Growth Factor-1 and Antioxidant Levels in Hypothalamic Amenorrhea and Impact on Bone Metabolism

Klasszikus és modern vizsgálómódszerek a csontérettségi kor és a pubertáskori növekedési csúcs meghatározására

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