Osteocalcin: an emerging biomarker for bone turnover

Rathore, Brijesh; Singh, Manisha; Kumar, Vishnu; Misra, Aparna

doi:10.18203/2320-6012.ijrms20162899

Cited by 11 publications

(8 citation statements)

References 29 publications

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“…Osteoprotegerin (OPG) is a very important regulatory factor in the bone remodeling and it is secreted by osteoblasts inhibiting RANKL (receptor activator of nuclear factor kappa beta ligand) induced osteoclastogenesis [8]. Osteocalcin (OC) is a major non-collagenous protein with high affinity for calcium ions, which promotes absorption to hydroxyapatite in bone matrix, thus regulating bone mineralization process [13]. Nuclear factor kappa beta 105 (NFkB-105) is a member of the transcriptional factor family and is involved in many signaling pathways essential for normal cellular functions and RANKL induced osteoclastogenesis [14].…”

Section: Introductionmentioning

confidence: 99%

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

et al. 2019

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Background: Strontium (Sr) enriched biomaterials have been used to improve bone regeneration in vivo. However, most studies provide only two experimental groups. The aim of our study was to compare eleven different bone sample groups from osteoporotic and healthy rabbits’ femoral neck, as it is the most frequent osteoporotic fracture in humans. Methods: Osteoporotic bone defects were filled with hydroxyapatite 30% (HA) and tricalcium phosphate 70% (TCP), 5% Sr-enriched HA30/TCP70, HA70/TCP30, or Sr-HA70/TCP30 granules and were compared with intact leg, sham surgery and healthy non-operated bone. Expression of osteoprotegerin (OPG), nuclear factor kappa beta 105 (NFkB-105), osteocalcin (OC), bone morphogenetic protein 2/4 (BMP-2/4), collagen I (Col-1α), matrix metalloproteinase 2 (MMP-2), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2), interleukin 1 (IL-1) and interleukin 10 (IL-10) was analyzed by histomorphometry and immunohistochemistry. Results: Our study showed that Sr-HA70/TCP30 induced higher expression of all above-mentioned factors compared to intact leg and even higher expression of OC, MMP-2 and NFkB-105 compared to Sr-HA30/TCP70. HA70/TCP30 induced higher level of NFkB-105 and IL-1 compared to HA30/TCP70. Conclusion: Sr-enriched biomaterials improved bone regeneration at molecular level in severe osteoporosis and induced activity of the factors was higher than after pure ceramic, sham or even healthy rabbits.

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Section: Introductionmentioning

confidence: 99%

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

et al. 2019

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“…When the bone resorption occurs, osteocalcin is released from the bone matrix into blood. Thus, serum osteocalcin concentrations increased in osteoporotic patients [9]. It was demonstrated in this research that group with daily per-oral nicotine administration has lower level of serum osteocalcin.…”

Section: Discussionmentioning

confidence: 88%

Effects of nicotine on markers of bone turnover in ovariectomized rats

Sananta¹,

Jonatan²,

Ernanda³

et al. 2019

Pan Afr Med J

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Introduction Osteoporosis is characterized by low bone mass and density, as well as change in microarchitecture of bone tissue leading to decreased bone strength. In vitro research shows nicotine can increase osteoblast activity and proliferation, also suppress osteoclast activity. Therefore we explore nicotine anti-resorptive property by in vivo true experimental and randomized posttest only controlled group research that was conducted in 18-20 weeks old Rattus norvegicus . Methods Twenty-five female rats were divided into five groups, with 5 rats per group. The first group represented normal rats (Sham), while the second to fifth group underwent bilateral ovariectomy. The second group serves as positive control group (ovariectomy-only/OVX). The third to fifth group serve as dose 1 (P1-0.25mg/kg), dose 2 (P2-0.5 mg/kg), and Dose 3 (P3-0.75 mg/kg) treatment group receiving daily per-oral nicotine for 28 days, started 3 weeks post- ovariectomy. After 28 days treatment, the serum was checked. Results Nicotine has dose-dependent manner on serum osteocalcin and serum DPD level. Level of osteocalcin in P2 group was significantly lower (Mann-Whitney, p = 0.008) compared to OVX group (59.4% lower). Level of DPD in all group was not significantly different (ANOVA, p < 0.05) but shows lowest level in P2 group. For serum calcitonin level, there's no significant different between groups. Conclusion Nicotine at right low-dose might be able to inhibit osteoclast activity, thus open a possibility of anti-resorptive property of nicotine.

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“…In context of normal renal function, OC and its fragments are rapidly cleared by the kidney, contributing to the pool of urinary Gla residues. Rathore et al [131] supported the idea that OC fragments accumulate and are detectable in renal failure, proposing urinary OC as future marker of bone turnover regardless of its limitations as age related renal impairment or higher pre-analytical variability compared to OC serum assays.…”

Section: Discussionmentioning

confidence: 99%

Vitamin K Dependent Proteins in Kidney Disease

Silaghi

Ilyés

Filip

et al. 2019

IJMS

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Patients with chronic kidney disease (CKD) have an increased risk of developing vascular calcifications, as well as bone dynamics impairment, leading to a poor quality of life and increased mortality. Certain vitamin K dependent proteins (VKDPs) act mainly as calcification inhibitors, but their involvement in the onset and progression of CKD are not completely elucidated. This review is an update of the current state of knowledge about the relationship between CKD and four extrahepatic VKDPs: matrix Gla protein, osteocalcin, growth-arrest specific protein 6 and Gla-rich protein. Based on published literature in the last ten years, the purpose of this review is to address fundamental aspects about the link between CKD and circulating VKDPs levels as well as to raise new topics about how the interplay between molecular weight and charge could influence the modifications of circulating VKDPs at the glomerular level, or whether distinct renal etiologies have effect on VKDPs. This review is the output of a systematic literature search and may open future research avenues in this niche domain.

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Osteocalcin: an emerging biomarker for bone turnover

Cited by 11 publications

References 29 publications

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

Effects of nicotine on markers of bone turnover in ovariectomized rats

Vitamin K Dependent Proteins in Kidney Disease

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