Osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide treatment

Chiu, Pu-Rong; Hu, Yue; Hsieh, Bau-Shan; Huang, Tzu-Ching; Cheng, Hsiao-Ling; Huang, Liwen; Chang, Kee-Lung

doi:10.1016/j.biocel.2016.08.036

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…Additionally, an in vitro study showed arsenic-induced inhibition of proliferation and induction of apoptosis of bone marrow-derived mesenchymal cells [47], osteoblasts, and chondrocytes [48]. Arsenic was also found to increase the generation of reactive oxygen species in osteoblasts [49] and induce apoptosis. This phenomenon may be even more dangerous for cervids, which suffer from cyclic physiological osteoporosis during antler growth [50][51][52][53][54].…”

Section: Discussionmentioning

confidence: 98%

Accumulation of Toxic Elements in Bone and Bone Marrow of Deer Living in Various Ecosystems. A Case Study of Farmed and Wild-Living Deer

Tajchman

Ukalska‐Jaruga

Bogdaszewski

et al. 2020

Animals

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The aim of the study was to determine the concentrations of toxic elements accumulated in the bone marrow and bones (Cervus elaphus). The studies were carried out on two groups of young stags: farmed (n = 6) and wild (n = 9). Their body weights were measured and bone and bone marrow samples were collected. The concentrations of toxic elements were analyzed using the inductively coupled plasma mass spectrometry technique. The mean aluminum content in the bone marrow and bones of the farmed animals was significantly higher than in the wild group (p < 0.05). The mean concentration of arsenic, barium and lead in the bones of the wild red deer was significantly higher than in the bones of the farmed animals (p < 0.05), while the cadmium concentration in the bones of the farmed red deer exceeded the value determined in the wild animals. A significant difference was found between the mean concentrations of aluminum, arsenic, barium, lead, vanadium and nickel in the bone marrow and bones of both red deer groups (p < 0.05). Although the study involved animals living in an uncontaminated area, the concentrations of some heavy metals were higher than values reported from industrial regions.

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Section: Discussionmentioning

confidence: 98%

Accumulation of Toxic Elements in Bone and Bone Marrow of Deer Living in Various Ecosystems. A Case Study of Farmed and Wild-Living Deer

Tajchman

Ukalska‐Jaruga

Bogdaszewski

et al. 2020

Animals

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“…1). Although NRF2 pathway activation by iAs has been reported in various cell types [28][29][30], however, the experimental data in vivo are very limited and not fully elucidated in humans. Several in vitro experiments have indicated that the TRX system is involved in As-induced cell responses.…”

Section: As-mediated Activation Of Nrf2-keap1 Antioxidant Pathwaymentioning

confidence: 99%

Effect of arsenic exposure on Nrf2-Keap1 pathway and epigenetic modification

et al. 2016

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Arsenic (As) is a known toxic element and carcinogen. Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular adaptation to oxidants and electrophiles by inducing antioxidant genes in response to redox stress. To explore associations between As level and NRF2-regulated cytoprotective genes expression, an observational study was conducted in a population of 61 occupationally exposed men with median (Me) age 50 years (interquartile range (IQR) 42-54) and in a control group of 52 men aged 40 (IQR 31-51.5) without occupational exposure. NRF2, KEAP1, GSTP1, HMOX1, NQO1, PRDX1, and TXNRD1 transcript levels were determined by means of quantitative real-time PCR along with the gene expression, methylation of NRF2 and KEAP1, as well as global DNA methylation were assessed. The median urine As tot. level in the exposed and control group was found to be 21.8 μg/g creat. (IQR 15.5-39.8 μg/g creat.) and 3.8 μg/g creat. (IQR 2.5-9.3) (p < 0.001). Global DNA methylation was significantly higher in occupationally exposed workers than in controls (Me 14.1 (IQR 9.5-18.1) vs Me 8.5 (IQR 5.9-12.6) p < 0.0001). NRF2 mRNA level was positively correlated with expression of all investigated NRF2-target genes in both groups (0.37 > R < 0.76, all p values < 0.0001). The multivariate linear regression adjusting for global methylation showed that As(III) level was significantly associated with expression of TXNRD1, GSTP1, HMOX1, and PRDX1. The results of this study indicate that arsenic occupational exposure is positively associated with global DNA methylation. The findings provide evidence for rather inactivation of NRF2-KEAP1 pathway in response to chronic arsenic exposure.

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“…As accumulates in the liver, spleen, gastrointestinal tract, and hard tissues such as bone, competing with the phosphate group in hydroxyapatite crystals, forming apatite-arsenate and other arsenate crystals. Different studies have shown that in the context of bone diseases such as Paget's disease, the As poisoning of the bone tissue, generates an imbalance of bone remodeling, and the increase in osteoblasts oxygen free radicals (Dani, 2013;Chiu et al, 2016;Rodríguez & Mandalunis, 2018). Interestingly, the most frequent site of OSCC in this cohort of patients was the gingiva and alveolar ridge followed by the tongue margin.…”

Section: Discussionmentioning

confidence: 72%

Oral Squamous Cell Carcinoma Associated with Arsenic Exposure: A Case Series from Argentina

Leonardi¹,

Gilligan²,

Pánico³

2020

Int. J. Odontostomat.

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Many areas of South America are directly affected by Arsenic (As) contaminated groundwater. A high percentage of the water samples taken in multiple areas of Argentina had As concentrations above the WHO level recommended guidelines. This condition was previously associated with an increased risk of chronic diseases, including different cancers. Long-term As exposure was proposed as a risk factor for Oral Squamous Cell Carcinoma (OSCC). The aim of this study is to present a series cases of Argentine patients diagnosed with OSCC who have consumed water contaminated with As for more than 10 years. Clinical data were obtained from the archive of Clinical Records Histories of the

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Osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide treatment

Cited by 8 publications

References 40 publications

Accumulation of Toxic Elements in Bone and Bone Marrow of Deer Living in Various Ecosystems. A Case Study of Farmed and Wild-Living Deer

Accumulation of Toxic Elements in Bone and Bone Marrow of Deer Living in Various Ecosystems. A Case Study of Farmed and Wild-Living Deer

Effect of arsenic exposure on Nrf2-Keap1 pathway and epigenetic modification

Oral Squamous Cell Carcinoma Associated with Arsenic Exposure: A Case Series from Argentina

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