Osteoblastoma of the mandible: Clinicopathologic study of four cases and literature review

Capodiferro, Saverio; Maiorano, Eugenio; Giardina, C; Lacaita, Maria Grazia; Muzio, Lorenzo Lo

doi:10.1002/hed.20192

Cited by 38 publications

(35 citation statements)

References 15 publications

(25 reference statements)

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“…While no discomfort was reported in the present case, recent literature indicates that significantly fewer patients experience pain associated with this neoplasm than was previously suggested [1]. The radiographic features of osteoblastoma can vary from a well-demarcated to illdefined osteolytic lesion with variable internal structure that can range from entirely radiolucent to our finding of a central radiopacity with radiolucent periphery [1][2][3].…”

Section: Differential Diagnosissupporting

confidence: 38%

“…The differential diagnosis included osteosarcoma, juvenile active ossifying fibroma, and calcifying epithelial odontogenic tumor. Osteoblastoma is a rare primary bone tumor that typically occurs in patients under the age of 30, with a slight female predominance and a predilection for the mandible, particularly the posterior segments [1,2]. Pain and swelling with bone expansion are common clinical features [1,3].…”

Section: Differential Diagnosismentioning

confidence: 99%

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Clinical–Pathological Conference: Case 4

McNamara

Kernig²,

Kreuter

et al. 2010

Head and Neck Pathol

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A 9-year-old male with a non-contributory medical history presented with left mandibular swelling. His mother had first noticed swelling in the area 2 months earlier, but stated that it seemed to resolve, only to develop again over the last 2 weeks. The boy had no complaints of pain, tenderness or altered sensation of his lower lip.Extraoral examination revealed mild facial asymmetry with enlargement of the body region of the left posterior mandible. The overlying skin lacked erythema or warmth and no anesthesia or paresthesia of the left lower lip was detected. Intraoral examination showed marked buccolingual expansion of the mandible centered on tooth #19 with vertical enlargement to the height of the occlusal plane; tooth #19 appeared ''engulfed.'' The mucosa was intact and of normal color (Fig.

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Section: Differential Diagnosissupporting

confidence: 38%

Section: Differential Diagnosismentioning

confidence: 99%

Clinical–Pathological Conference: Case 4

McNamara

Kernig²,

Kreuter

et al. 2010

Head and Neck Pathol

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“…This disease accounts for 1% 3,4 or less 5 of all bone tumors and most commonly involves the spine and sacrum of young individuals. 2 The second most common location is the mandible, followed by other craniofacial bones. 3 Other more rare locations in the head and neck include the temporal bone, where 10 cases have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…6 Clinically, osteoblastomas present mainly with pain, swelling, and expansion of the bone cortex. 2 An osteoid osteoma is histopathologically similar but is smaller and is associated with pain that is often nocturnal and relieved with the use of aspirin or other NSAIDs. 3 These typical symptoms occur in approximately 80% of the patients.…”

Section: Discussionmentioning

confidence: 99%

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Osteoblastoma of the Hyoid Bone

Rivera-Serrano¹,

Branstetter²,

Johnson³

2009

AJNR Am J Neuroradiol

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SUMMARY: Osteoblastoma is a rare bone tumor that usually affects the vertebrae. We present the first known case of osteoblastoma arising in the hyoid bone, in a patient who presented with a neck mass and dysphagia. The radiographic appearance of the tumor is similar to that of low-grade chondrosarcoma, with well-defined expansion of the bone and central chondroid matrix. ABBREVIATIONS:NSAIDs ϭ nonsteroidal anti-inflammatory drugs S olid primary tumors of the hyoid bone are exceedingly rare. Reported cases have included chondrosarcoma, plasmacytoma, osteosarcoma, giant cell tumor, aneurysmal bone cyst, and benign osteoma.1 Patients with hyoid bone tumors usually present with dysphagia and may have a palpable neck mass. The goal of imaging is to distinguish benign from malignant causes and to assist in surgical planning.Osteoblastoma is a rare benign bone tumor first described in 1956. In the head and neck, osteoblastoma may arise in the maxilla, mandible, temporal bone, and, very rarely, in the larynx.2 Surgical excision, when feasible, is usually curative. We present the first known case of an osteoblastoma arising in the hyoid bone. Case ReportA healthy 51-year-old man presented with a mass in the left side of the neck, which he had noticed 3 weeks earlier. He reported pain in the contralateral neck for the past 5 years and mild dysphagia of recent onset, but his voice was unchanged. Thirty years ago the patient had undergone chemoradiation and surgery for a fibrosarcoma in the soft tissues in his posterior neck. Physical examination was remarkable for a hard nontender left-sided neck mass at the level of the hyoid bone. This mass was freely mobile and moved up and down with swallowing. The overlying skin was intact. Flexible transnasal laryngoscopy showed indentation of the left lateral pharyngeal wall at the level of the hyoid bone.CT revealed a 3-cm well-defined spheric mass with a calcified ring and a partially calcified central matrix, arising within the left hyoid bone, causing extrinsic compression of the hypopharynx (Fig 1). On the basis of these imaging features, a diagnosis of low-grade chondrosarcoma of the hyoid bone was proposed. Differential considerations included bony tumors such as osteosarcoma, enchondroma, and ossifying fibroma.The patient underwent resection of the left hyoid bone, from which he recovered uneventfully. The pathologic diagnosis was a 3-cm hyoid osteoblastoma with a secondary aneurysmal bone cyst component. Focally, the tumor broke through the cortex into the adjacent soft tissue, but the surgical margin in this area appeared free. A specimen radiograph showed the internal calcified matrix in greater detail (Fig 2). DiscussionSolid primary tumors of the hyoid bone are exceedingly rare, and reported cases have included plasmacytoma, osteosarcoma, giant cell tumor, aneurysmal bone cyst, osteoma, and chondrosarcoma.

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