Osteoblastic differentiation under controlled bioactive ion release by silica and titania doped sodium-free calcium phosphate-based glass

Synthesis of novel quaternary silica hybrid bioactive microspheres

“…The restricted clinical application of autografts, due to limited donor availability, resulted in alternative solutions of synthetic bone implants . The great challenge for the synthetic implants was to provide increased osteogenic properties through stimulated cellular responses critical in bone regeneration . Thus, in order to enhance their repair efficacy synthetic bone implants were combined with bioactive materials, such as mesoporous silica nanoparticles, calcium phosphate nanocrystals, calcium lactate nanofibers, hydroxyapatite nanorods and nanopowder, dextran–silicate xerogels, silica PS, and PMMA microspheres, silica binary and ternary microspheres, chitosan/silica nanoparticles, and silica/PEG composites .…”

“…24,25 The great challenge for the synthetic implants was to provide increased osteogenic properties through stimulated cellular responses critical in bone regeneration. [11][12][13][14][15][16][17][18][19][20] Thus, in order to enhance their repair efficacy synthetic bone implants were combined with bioactive materials, such as mesoporous silica nanoparticles, 2,11,19 calcium phosphate nanocrystals, 20 calcium lactate nanofibers, 5 hydroxyapatite nanorods 3 and nanopowder, 21 dextran-silicate xerogels, 7 silica PS, and PMMA microspheres, 8 silica binary and ternary microspheres, 9 chitosan/silica nanoparticles, 10 and silica/PEG composites. 27 In general, two alternative directions were followed (i) the noncovalent (physical entrapment, adsorption and ionic complexation) incorporation of bioactive materials in synthetic bone implants and (ii) the formation of hybrid bioactive-synthetic bone implants (hybridization).…”

Development of degradable and bioactive composite as bone implants by incorporation of mesoporous bioglass into poly(l-lactide)

“…In this study, the ALP activity of the MC3T3-E1 cells on C50 was significantly higher than C25 and PLLA at 7 days, revealing that the C50 with high MBG content obviously promoted cell differentiation. Previous studies have shown that Si and Ca ions from bioactive glass dissolution could stimulate osteoblasts proliferation and differentiation [33][34][35]. In this study, the continuous dissolution of the composite produced a Si and Ca-rich environment that might be responsible for stimulating cell responses such as proliferation and differentiation.…”

In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

“…are facilely adjusted to meet requirements of various applications [18,19]. Absorbable PG can be used as blood contacting materials [20], nerve guidance channel [21], and reinforcement phase for composite materials [22], etc.…”