Osteobiologies for Spinal Fusion from Biological Mechanisms to Clinical Applications: A Narrative Review
Byeong-Rak Keum,
Hong Jin Kim,
Gun-Hwa Kim
et al.
Abstract:Degenerative lumbar spinal disease (DLSD), including spondylolisthesis and spinal stenosis, is increasing due to the aging population. Along with the disease severity, lumbar interbody fusion (LIF) is a mainstay of surgical treatment through decompression, the restoration of intervertebral heights, and the stabilization of motion segments. Currently, pseudoarthrosis after LIF is an important and unsolved issue, which is closely related to osteobiologies. Of the many signaling pathways, the bone morphogenetic p… Show more
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