Osteoarticular sporotrichosis in an immunocompetent patient

Sendrasoa, Fandresena Arilala; Ranaivo, Irina Mamisoa; Sata, Michio; Razanakoto, Naina Harinjara; Andrianarison, Malalaniaina; Ratovonjanahary, Volatantely; Raharolahy, Onivola; Rakotoarisaona, Mendrika Fifaliana; Rasamoelina, Tahinamandranto; Andrianarivelo, Mala Rakoto; Ramarozatovo, Lala Soavina; Rabenja, F. Rapelanoro

doi:10.1016/j.mmcr.2021.03.007

Cited by 5 publications

(4 citation statements)

References 11 publications

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“… 2 , 102 , 104 In osteoarticular lesions, the initial dose of itraconazole should be 400 mg/day for six months. 2 , 46 , 109 , 110 After this period, it can be discontinued if cure is achieved, except in HIV/AIDS patients, when the drug should be maintained until CD4+ >200 cells/μL. If there are still signs or symptoms, the treatment continues with 200 to 400 mg/day for another six months (authors' personal experience).…”

Section: Resultsmentioning

confidence: 99%

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Orofino-Costa

Freitas²,

Bernardes-Engemann

et al. 2022

Anais Brasileiros de Dermatologia

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Section: Resultsmentioning

confidence: 99%

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Orofino-Costa

Freitas²,

Bernardes-Engemann

et al. 2022

Anais Brasileiros de Dermatologia

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“…Possibly, due to this relatively early diagnosis and initiation of treatment, there were no extensive destructive changes. They also emphasized the importance of clinical suspicion for early diagnosis and treatment [15].…”

Section: Discussionmentioning

confidence: 99%

“…Although osteoarticular sporotrichosis is rare (up to 3-4% of cases) [15], this system is the third most affected site after the skin and mucosa. In disseminated disease, there are cases varying from asymptomatic to extremely painful bone or joint involvement, while localized cases commonly present as large-joint painful monoarthritis [1,16].…”

Section: Introductionmentioning

confidence: 99%

Osteoarticular Sporotrichosis of the Knee Caused by Sporothrix brasiliensis: Two Similar Cases with Different Outcomes

de Sousa,

Ferreira,

de Lima

et al. 2023

JoF

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Sporotrichosis is the most frequent subcutaneous or implantation mycosis in Latin America, and its transmission occurs as a result of traumatic inoculation into the skin by organic matter containing the thermodimorphic fungi of the genus Sporothrix. Although cutaneous forms are more common, another important site is the osteoarticular system, whose hematogenous involvement is commonly associated with disseminated forms, especially in people who have an immunosuppressive condition, such as HIV/AIDS, chronic steroid use, and alcohol abuse. We present two cases of osteoarticular sporotrichosis of the knee caused by Sporothrix brasiliensis and followed up at our institution, with different outcomes. In the cases presented here, aging, anatomical sites, comorbidities, subtherapeutic serum levels, low adherence to treatment, and late diagnosis for different reasons may explain the observed outcomes. Early diagnosis of Sporothrix infection is critical in preventing complications, including death. We also highlight the importance of multidisciplinary follow-up and adherence to treatment for a favorable outcome.

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“…Usually, the diagnosis of sporotrichosis takes several months, due to the numerous possible differential diagnoses, especially for bacterial skin infections 9 . In regions of endemic transmission, such as Brazil, where zoonotic transmission is frequent, the diagnosis tends to be earlier.…”

Section: Discussionmentioning

confidence: 99%

Severe form of lymphocutaneous sporotrichosis: a case report

Martins,

Durães,

Teixeira

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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Sporotrichosis is the most frequent subcutaneous mycosis in Latin America. It is caused by species of the genus Sporothrix. Infection in humans occurs through the entry of the fungus into the skin. Zoonotic outbreaks involving cats in the transmission of the disease have been frequently reported. The lymphocutaneous form is the most commonly observed and the upper limbs are the most affected sites. We report a case of a 64-year-old healthy female patient with a lymphocutaneous form with rapid progression of lesions, which was refractory to initial treatment with itraconazole. Treatment with liposomal amphotericin B was performed with a satisfactory resolution, but aesthetic and functional sequelae in the left upper limb were installed.

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Osteoarticular sporotrichosis in an immunocompetent patient

Cited by 5 publications

References 11 publications

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Osteoarticular Sporotrichosis of the Knee Caused by Sporothrix brasiliensis: Two Similar Cases with Different Outcomes

Severe form of lymphocutaneous sporotrichosis: a case report

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