Osteoarticular Mycoses

Gamaletsou, Maria N.; Rammaert, Blandine; Brause, Barry D.; Bueno, Marimelle A; Dadwal, Sanjeet; Henry, Michael; Katragkou, Aspasia; Kontoyiannis, Dimitrios P.; McCarthy, Matthew W; Miller, Andy O.; Moriyama, Brad; Pana, Zoi Dorothea; Petraitienė, Rūta; Petraitis, Vidmantas; Roilides, Emmanuel; Sarkis, Jean-Pierre; Simitsopoulou, Maria; Sipsas, Nikolaos V.; Taj-Aldeen, Saad J.; Zeller, Valérie; Lortholary, Olivier; Walsh, Thomas J.

doi:10.1128/cmr.00086-19

Cited by 13 publications

(13 citation statements)

References 1,202 publications

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“…Common osteoarticular fungal infections are caused by Candida species and Aspergillus species. Non- Aspergillus fungal infections are very uncommon 6,8,9 .…”

Section: Discussionmentioning

confidence: 99%

“…Common portals of entry of these fungi are respiratory sites and integumentary sites. Osteoarticular infection usually results from direct traumatic inoculation of the fungal pathogen 6 . The infection progresses slowly.…”

Section: Discussionmentioning

confidence: 99%

“…The Scedosporium genus has 5 species. In the Scedosporium genus, the most common causative fungus for osteoarticular infection is Scedosporium apiosporium , causing almost 40% of all cases 6 . Scedosporium boydii (formerly known as Pseudallescheria boydii ) is an opportunistic fungus isolated from soil.…”

Section: Discussionmentioning

confidence: 99%

“…Pediatric fungal osteoarticular infections are uncommon. Scedosporium bone and joint infections are rare [6][7][8][9] . There is no reported case of EO due to Scedosporium boydii because of direct inoculation.Fungal infections are difficult to diagnose because of the absence of peculiar laboratory markers, insidious clinical presentation, and failure to consider fungal infection as a differential diagnosis.…”

mentioning

confidence: 99%

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Fungal Osteomyelitis of the Proximal Tibial Epiphysis and Septic Arthritis Secondary to an Open Wound

Ranade,

Gandhi

2023

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Case: A 9-year-old boy presented with a painful, swollen knee. He had a wound on the knee 2 months ago after a fall in contaminated water. At another hospital, this was treated with debridement twice, and the patient received several antibiotics. Imaging showed septic arthritis and epiphyseal osteomyelitis involving the proximal medial tibia. Surgical debridement and joint washout were performed. Fungal cultures grew Scedosporium boydii. Antifungal treatment with voriconazole was given. At a 5-year follow-up, we noticed favorable outcomes without any complications. Conclusions: Fungal osteomyelitis because of direct inoculation should be considered a rare differential diagnosis while treating epiphyseal osteomyelitis.

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“…Common osteoarticular fungal infections are caused by Candida species and Aspergillus species. Non- Aspergillus fungal infections are very uncommon 6,8,9 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Fungal Osteomyelitis of the Proximal Tibial Epiphysis and Septic Arthritis Secondary to an Open Wound

Ranade,

Gandhi

2023

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“…Resection or debridement may also be warranted for the management of osteoarticular diseases caused by the hyaline molds, as exemplified by musculoskeletal infections caused by Scedosporium spp. and Lomentospora prolificans [ 204 ]. Disseminated disease is best managed with antifungal therapy and restoration of the innate host immunity.…”

Section: Management Of Sino-pulmonary Hyalohyphomycosesmentioning

confidence: 99%

Non-Aspergillus Hyaline Molds: A Host-Based Perspective of Emerging Pathogenic Fungi Causing Sinopulmonary Diseases

Jacobs

Walsh

2023

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The incidence of invasive sino-pulmonary diseases due to non-Aspergillus hyaline molds is increasing due to an enlarging and evolving population of immunosuppressed hosts as well as improvements in the capabilities of molecular-based diagnostics. Herein, we review the following opportunistic pathogens known to cause sinopulmonary disease, the most common manifestation of hyalohyphomycosis: Fusarium spp., Scedosporium spp., Lomentospora prolificans, Scopulariopsis spp., Trichoderma spp., Acremonium spp., Paecilomyces variotii, Purpureocillium lilacinum, Rasamsonia argillacea species complex, Arthrographis kalrae, and Penicillium species. To facilitate an understanding of the epidemiology and clinical features of sino-pulmonary hyalohyphomycoses in the context of host immune impairment, we utilized a host-based approach encompassing the following underlying conditions: neutropenia, hematologic malignancy, hematopoietic and solid organ transplantation, chronic granulomatous disease, acquired immunodeficiency syndrome, cystic fibrosis, and healthy individuals who sustain burns, trauma, or iatrogenic exposures. We further summarize the pre-clinical and clinical data informing antifungal management for each pathogen and consider the role of adjunctive surgery and/or immunomodulatory treatments to optimize patient outcome.

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Histoplasmosis mimicking a tumor of the thumb in a patient with neurofibromatosis type I: A case report and review of the literature

Levine,

Manivel,

Luna

2023

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Osteoarticular Mycoses

Cited by 13 publications

References 1,202 publications

Fungal Osteomyelitis of the Proximal Tibial Epiphysis and Septic Arthritis Secondary to an Open Wound

Fungal Osteomyelitis of the Proximal Tibial Epiphysis and Septic Arthritis Secondary to an Open Wound

Non-Aspergillus Hyaline Molds: A Host-Based Perspective of Emerging Pathogenic Fungi Causing Sinopulmonary Diseases

Histoplasmosis mimicking a tumor of the thumb in a patient with neurofibromatosis type I: A case report and review of the literature

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