Osteoarticular Manifestations of Mycobacterium Tuberculosis Infection

Zychowicz, Michael E.

doi:10.1097/nor.0b013e3181fb9a92

Cited by 6 publications

(4 citation statements)

References 15 publications

(54 reference statements)

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“…Tuberculosis has been one of the most intriguing problems for the medical fraternity in the developing world. In tubercular infections of the bones and joints, the hip joint ranks second only to tuberculosis of the spine [7]. The introduction of chemotherapy revolutionised the medical management of tuberculosis by reducing the duration of the disease and decreasing the relapse rate [8].…”

Section: Discussionmentioning

confidence: 99%

Functional improvement after hip arthroscopy in cases of active paediatric hip joint tuberculosis: A retrospective comparative study vis-à-vis conservative management

Tiwari

Khan

Kumar

et al. 2015

Journal of Children's Orthopaedics

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PurposeTuberculosis of the hip joint is a significant cause of preventable disability, especially in children. The aim of our study was to evaluate the functional results of hip arthroscopy done in a cohort of patients with hip joint tuberculosis and to compare them with the outcome of conservatively managed cases.MethodsThis was a retrospective cohort study in which we evaluated the records of 22 hip arthroscopies performed in known cases of tuberculosis of the hip joint in children less than 12 years of age. A note of the demographic and clinical parameters like age, duration of symptoms, stage of the disease, time period of follow-up, any complications during surgery, and pre- and post-operative modified Harris hip score (MHHS) was made in all cases. We compared the results with an age-matched cohort of 44 children with hip joint tuberculosis who were treated non-operatively with anti-tuberculosis therapy and traction in the same tertiary care institute.ResultsThe arthroscopic findings in our series included synovitis, chondral erosions of the femoral head and/or acetabulum, pannus formation over the femoral head and/or acetabulum, and labral tears. The various arthroscopic procedures which were done included joint lavage, synovectomy, labral debridement and cheilectomy. The mean follow-up was 45 months, with the minimum being 36 months. There was a statistically significant change in the mean MHHS after hip arthroscopic procedures (p < 0.001); the difference in the mean post- and pre-operative MHHS was independent of age, stage or duration of follow-up. There was a statistically significant difference (p < 0.05) between the magnitude of improvement in MHHS after hip arthroscopy and that after conservative management.ConclusionsArthroscopy of the hip joint in children in cases of tuberculosis can serve as an emerging therapeutic modality. It is an effective and safe minimally invasive procedure, and helps in improving the functional outcome in early disease.

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Section: Discussionmentioning

confidence: 99%

Functional improvement after hip arthroscopy in cases of active paediatric hip joint tuberculosis: A retrospective comparative study vis-à-vis conservative management

Tiwari

Khan

Kumar

et al. 2015

Journal of Children's Orthopaedics

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“…Rabbits were inoculated directly with M. tuberculosis within the vertebral body (corpus) as described elsewhere [ 9 10 11 12 13 ]. Of the 14 rabbits inoculated, the intervention group and control group each comprised three rabbits.…”

Section: Methodsmentioning

confidence: 99%

New Bone Formation in Tuberculous-Infected Vertebral Body Defect after Administration of Bone Marrow Stromal Cells in Rabbit Model

et al. 2016

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Study DesignPreliminary experimental study using a rabbit spondylitis model.PurposeTo observe the ossification in a micro-environment containing live Mycobacterium tuberculosis transplanted with bone marrow stromal cells (BMSCs) in rabbits.Overview of LiteratureBMSCs differentiate to osteoblasts and then osteocytes during ossification. Mycobacterium tuberculosis does not affect BMSC growth in vitro.MethodsSix rabbits were divided into two groups of three rabbits. One group was positive for spondylitis tuberculosis by culture, polymerase chain reaction (PCR), and histopathologically. The other group was positive by PCR and histopathologically. Both groups were treated using BMSC transplantation and anti-tuberculosis drugs. After 6 weeks, ossification was evaluated by enumerating the number of osteoblasts, osteocytes, and lesion level of calcium.ResultsMean number of osteoblasts was 207.00±31.00 in the first group and 220.33±73.46 in the second group. Mean number of intra-lesions osteocytes was in the first and second group was 18.33±30.04 and 31.00±26.87, respectively. Mean calcium level in the first group and second group was 2.94%±0.89% and 2.51%±0.13%, respectively. Total ossification score in the first and second group was 31.00 and 25.67, respectively.ConclusionsMycobacterium tuberculosis provides support for new bone formation by stimulating intra-lesion calcium metabolism. The microscopic environment containing live Mycobacterium tuberculosis enhances ossification.

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“…Skeletal involvement occurs in 1-3% of all patients with tuberculosis [1,2]. Tuberculosis (TB) bacteria can infect any bone, joint, tendon, or bursa; however, the most common musculoskeletal site for infection includes the spine and weight-bearing joints of the hip and knee [2].…”

Section: Introductionmentioning

confidence: 99%

White tumor of the wrist: A rare localization of tuberculosis

Fianyo

Oniankitan

Agoda-Koussema

et al. 2015

The Egyptian Rheumatologist

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Background: Tuberculosis (TB) bacteria can infect any bone, joint, tendon, or bursa; however, the most common musculoskeletal site for infection includes the spine and weight-bearing joints of the hip and knee. A tubercular involvement of the wrist is rare.Aim of the work: To describe a rare case of tuberculosis of wrist.Case report: A 37-year-old man with a history of immunosuppressed Human Immunodeficiency Virus (HIV) infection was referred to the Rheumatology department for a 10 month history of lowgrade fever, swelling and pain in the wrist. X-ray and wrist CT scan, revealed an osteolytic lesion of the wrist. Cold abscess aspiration cytology was negative for acid-fast bacilli but the Polymerase Chain Reaction, using Xpert MTB/RIF (Mycobacterium tuberculosis/resistance to rifampicin) diagnostic test done on the cold abscess fluid was positive in revealing Mycobacterium tuberculosis. The evolution under specific antibiotic treatment has been favorable, with the disappearance of wrist pain and a regression of swelling.Conclusion: This case highlights that TB should be taken into consideration when dealing with nonspecific chronic wrist arthritis, especially if the patient is immunocompromised HIV infected.

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Osteoarticular Manifestations of Mycobacterium Tuberculosis Infection

Cited by 6 publications

References 15 publications

Functional improvement after hip arthroscopy in cases of active paediatric hip joint tuberculosis: A retrospective comparative study vis-à-vis conservative management

Functional improvement after hip arthroscopy in cases of active paediatric hip joint tuberculosis: A retrospective comparative study vis-à-vis conservative management

New Bone Formation in Tuberculous-Infected Vertebral Body Defect after Administration of Bone Marrow Stromal Cells in Rabbit Model

White tumor of the wrist: A rare localization of tuberculosis

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