Osteoarticular complications of brucellosis in Hamedan, an endemic area in the west of Iran

Hashemi, Seyyed Hamid; Keramat, Fariba; Ranjbar, Mahdy; Mamani, Mojgan; Farzam, Ali; Jamal-Omidi, Shirin

doi:10.1016/j.ijid.2007.01.008

Cited by 70 publications

(52 citation statements)

References 20 publications

(29 reference statements)

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“…In the present study, the manifestations of localized brucellosis, including peripheral arthritis and sacroilietis, were mentioned in 10 (12%) and 20 (24.1%) patients, respectively. Although peripheral arthritis was mentioned as the most prevalent osteoarticular complain of brucellosis in some studies (14,15), in other studies like the present research, sacroileitis was found as the most common musculoskeletal complication (16).…”

Section: Discussionmentioning

confidence: 41%

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Clinical Manifestations and Laboratory Findings of Brucellosis at Boo-Ali-Siena Hospital of Ghazvin Province of Iran

Najari

Sigaroudi

Rastgoo

2018

Jundishapur J Health Sci

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Background: Brucellosis as a zoonotic disease is controlled in many developed countries though it still remains endemic in the majority of Middle Eastern and developing countries. Objectives: The purpose of this study was to identify the demographic features, clinical manifestations, and laboratory tests of patients diagnosed with brucellosis in Ghazvin province of Iran. Methods: In this cross-sectional study, medical records of 83 cases with brucellosis (54 males and 29 females) over a 3-year period (from June, 2012 to June, 2015) were reviewed, retrospectively. Demographic features, clinical signs and symptoms, hematologic findings, and liver enzyme level were derived from the patients' medical record. Results: The mean age of cases was 42.5±18.3 years. Constitutional symptoms, which were noted in 45 (54%) cases, were the most common symptom of the disease. Clinical manifestations, including Sacroileitis, arthritis, and epididymo-orchitis were seen in 20 (24.1%), 10 (12%), and 7 (8.4%) cases, respectively. One case of Endocarditis (1.2%) was noted. Anemia as the most frequent blood abnormality was seen in 44 (53%) cases. Leukopenia and leukocytosis were noted in 17 (20.5%) and 9 (10.8%) patients, respectively. Thrombocytopenia and thrombocytosis were detected in 26 (31.3%) and 3 (3.6%) of the patients, respectively. Bicytopenia and pancytopenia were revealed in 9 (10.8%) and 11 (13.3%) cases, respectively. Elevated level of liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were detected in 29 (34.9), 37 (44.6), and 51 (61.5) patients, respectively. Conclusions: Brucellosis could affect every organ system of the human body. Variable manifestations and laboratory findings of brucellosis must be kept in mind, especially in endemic areas.

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Section: Discussionmentioning

confidence: 41%

“…Anemia, leukopenia, thrombocytopenia, leukocytosis, thrombocytosis, and elevated ESR were detected in patients with brucellosis in previous studies (12,16,21,24). Anemia, which was found in 44 (53%) patients, was found as the most common hematological abnormality in the present study.…”

Section: Discussionmentioning

confidence: 71%

Clinical Manifestations and Laboratory Findings of Brucellosis at Boo-Ali-Siena Hospital of Ghazvin Province of Iran

Najari

Sigaroudi

Rastgoo

2018

Jundishapur J Health Sci

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“…According to various studies, the frequency of osteoarticular complications has been reported in 10 to 80 % of patients (14,15). In a previous study in our region, the frequency of osteoarticular complications was 28.5%, of which 75.7% cases were of sacroiliitis (16). Laboratory diagnosis is based on culture, serology, and PCR.…”

Section: Discussionmentioning

confidence: 89%

Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of <i>Brucella</i> Isolates in Hamedan, Iran

et al. 2017

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“…Brucellosis is a public health problem in many developing countries [39]. In many brucellosis-endemic countries, health systems are not well-organized and the cases are considerably under-reported.…”

Section: Epidemiology and Distributionmentioning

confidence: 99%

Skeletal evidence of brucellosis in a medicolegal context: A report of two cases

Zorba¹,

Eliopoulos²,

Moraitis³

2017

RJLM

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Abstract:Brucellosis is a zoonosis caused by gram-negative bacteria of the genus Brucella. Osteoarticular complications are the most frequent symptoms of brucellosis occurring in up to 40% of the cases. Two brucellosis cases submitted to the Department of Forensic Medicine and Toxicology at the National and Kapodistrian University of Athens Medical School for forensic anthropological evaluation are reported. The value of the contribution of the brucellar lesions to the location of the most likely geographic origin of two missing individuals is presented. The presence of a pathologic condition, such as brucellosis, in skeletal remains can give significant information about the biological profile of an unidentified victim and greatly enhances the chances of obtaining a positive identification.

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Osteoarticular complications of brucellosis in Hamedan, an endemic area in the west of Iran

Abstract: Osteoarticular disease is the most common complication of brucellosis in Western Iran. Sacroiliitis is the most common form of osteoarticular complication. With the use of a proper treatment regimen, the prospect for recovery is good.

Cited by 70 publications

References 20 publications

Clinical Manifestations and Laboratory Findings of Brucellosis at Boo-Ali-Siena Hospital of Ghazvin Province of Iran

Clinical Manifestations and Laboratory Findings of Brucellosis at Boo-Ali-Siena Hospital of Ghazvin Province of Iran

Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of <i>Brucella</i> Isolates in Hamedan, Iran

Skeletal evidence of brucellosis in a medicolegal context: A report of two cases

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