Osteoarthritis of the knee after ACL reconstruction

Ferretti, Andrea; Conteduca, Fabio; Carli, Angelo De; Fontana, M.; Mariani, Pier Paolo

doi:10.1007/bf00186881

Cited by 141 publications

(124 citation statements)

References 10 publications

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“…As to the radiograph, several studies have reported that, after ACL reconstruction, the progression rate of OA increased (Ferretti et al, 1991;van der Hart et al, 2008). The surgical procedure for the ACL reconstruction may be of importance regarding the risk of eventual developing knee OA.…”

Section: Discussionmentioning

confidence: 99%

ACL reconstruction with BPTB autograft and irradiated fresh frozen allograft

Kim

Tian

Zhang

et al. 2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To analyze the clinical outcomes of arthroscopic anterior cruciate ligament (ACL) reconstruction with irradiated bone-patellar tendon-bone (BPTB) allograft compared with non-irradiated allograft and autograft. Methods: All BPTB allografts were obtained from a single tissue bank and the irradiated allografts were sterilized with 2.5 mrad of irradiation prior to distribution. A total of 68 patients undergoing arthroscopic ACL reconstruction were prospectively randomized consecutively into one of the two groups (autograft and irradiated allograft groups). The same surgical technique was used in all operations done by the same senior surgeon. Before surgery and at the average of 31 months of follow-up (ranging from 24 to 47 months), patients were evaluated by the same observer according to objective and subjective clinical evaluations. Results: Of these patients, 65 (autograft 33, irradiated allograft 32) were available for full evaluation. When the irradiated allograft group was compared to the autograft group at the 31-month follow-up by the Lachman test, the anterior drawer test (ADT), the pivot shift test, and KT-2000 arthrometer test, statistically significant differences were found. Most importantly, 87.8% of patients in the autograft group and just only 31.3% in the irradiated allograft group had a side-to-side difference of less than 3 mm according to KT-2000. The failure rate of the ACL reconstruction with irradiated allograft (34.4%) was higher than that with autograft (6.1%). The anterior and rotational stabilities decreased significantly in the irradiated allograft group. According to the overall International Knee Documentation Committee (IKDC), functional and subjective evaluations, and activity level testing, no statistically significant differences were found between the two groups. Besides, patients in the irradiated allograft group had a shorter operation time and a longer duration of postoperative fever. When the patients had a fever, the laboratory examinations of all patients were almost normal. Blood routine was normal, the values of erythrocyte sedimentation rate (ESR) were 5~16 mm/h and the contents of C reactive protein (CRP) were 3~10 mg/L. Conclusion: We conclude that the short term clinical outcomes of the ACL reconstruction with irradiated BPTB allograft were adversely affected. The less than satisfactory results led the senior authors to discontinue the use of irradiated BPTB allograft in ACL surgery and not to advocate using the gamma irradiation as a secondary sterilizing method.

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Section: Discussionmentioning

confidence: 99%

ACL reconstruction with BPTB autograft and irradiated fresh frozen allograft

Kim

Tian

Zhang

et al. 2009

J. Zhejiang Univ. Sci. B

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“…Knee traumas, in particular, represent over 40% of all sports injuries [5][6][7] and often result from traffic accidents with surgical restoration of joint stability not preventing future arthritis development [8][9][10][11]. The incidence of post-traumatic arthritis is therefore high -creating insistent demand for pharmacological intervention, directed at limiting the progression and propagation of destructive processes taking place in the early stages post-injury [2,12].…”

Section: Introductionmentioning

confidence: 99%

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury

Kaneva

Kerrigan

Grieco

et al. 2014

Biochemical Pharmacology

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Conclusion:Melanocortin peptide pre-treatment prevented chondrocyte death following mechanical impact to cartilage and led to a marked reduction of pro-inflammatory cytokines, whilst prompting the production of anti-inflammatory/pro-resolving cytokine IL-10.Development of small molecule agonists towards melanocortin receptors could thus be a viable approach for preventing chondrocyte inflammation and death within cartilage and represent an alternative approach for the treatment of osteoarthritis.

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“…Restoring knee-joint stability through ACL reconstruction has not been shown to decrease the incidence of posttraumatic OA in this patient population. However, some reports indicate that 50-60% of patients with ACL-reconstructed knees have radiographic evidence of OA after five years [1,3]. These data suggest that something other than, or in addition to, a biomechanical disturbance is responsible for the osteoarthritic changes seen after ACL rupture.…”

Section: Introductionmentioning

confidence: 99%

Changes in biochemical parameters after anterior cruciate ligament injury

Handa

Shirakura

Kimura³

et al. 2005

International Orthopaedics (SICO

106

133

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We studied the biochemical characteristics of human knees with deficient anterior cruciate ligaments (ACL) and analysed their relationship to the time after ligamentous injury. Thirty-two patients with isolated ACLinjured knees and six healthy volunteers were enrolled. Synovial fluid samples were centrifuged after aspiration during arthroscopic examination, and aliquots of supernatant were frozen and stored at −80°C. The samples were analysed for interleukin (IL)-1β, tumour necrosis factor (TNF)-α, IL-6, matrix metalloproteinase (MMP)-3, and tissue inhibitor of metalloproteinase (TIMP)-1 using commercially available sandwich enzyme-linked immunosorbent assay. In fluid from ACL-injured knees, the average concentrations of IL-6, MMP-3 and TIMP-1 were highly elevated in comparison with normal controls. There was a statistically significant correlation between the concentrations of MMP-3 and IL-6. The IL-6 and TIMP-1 concentrations were interrelated. The concentration of MMP-3 remained high, independent of the duration since the injury, whereas the TIMP-1 and IL-6 levels decreased. The results suggest that the timing of the treatment of an ACL-injured knee might be of importance.Résumé Nous avons étudié les caractéristiques biochimiques des genoux humains avec un ligament croisé antérieur défectueux (LCA) et avons analysé leur rapport au temps après la lésion ligamentaire. Trente-deux malades avec une lésion isolée du LCA et six volontaires sains ont été enrôlés.

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Osteoarthritis of the knee after ACL reconstruction

Cited by 141 publications

References 10 publications

ACL reconstruction with BPTB autograft and irradiated fresh frozen allograft

ACL reconstruction with BPTB autograft and irradiated fresh frozen allograft

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury

Changes in biochemical parameters after anterior cruciate ligament injury

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