Osteo-odonto-keratoprosthesis According to Strampelli Original Technique: A Retrospective Study With Up to 30 Years of Follow-up

Iannetti, Ludovico; Liberali, Marco; Armentano, Marta; Alisi, Ludovico; Visioli, Giacomo; Mastromarino, Davide; Brauner, Edoardo; Iannetti, Giorgio

doi:10.1016/j.ajo.2022.05.015

Cited by 4 publications

(14 citation statements)

References 24 publications

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“…[ 12 , 14 ] Compared to previous studies, Iannetti et al . [ 23 ] reported a higher retention rate of 99% at 20 years and 94% at 30 years. De la Paz et al .…”

Section: Discussionmentioning

confidence: 99%

“…In most studies, the best functional outcomes were seen in SJS followed by chemical burns and worse functional outcomes were seen in eyes with thermal injury and MMP. [ 19 - 23 ] Eyes with thermal injury had poorer VA due to associated optic neuropathy and retinal dysfunction from the initial injury. [ 12 , 14 , 18 , 24 ] Cicatricial disorders such as SJS cause a more localized damage predominantly affecting the ocular surface, in comparison to chemical burns, where the agent may penetrate the surface and damage the intraocular structures, also causing glaucoma, thus limiting functional success.…”

Section: Discussionmentioning

confidence: 99%

“…[ 12 , 14 , 18 , 24 ] Cicatricial disorders such as SJS cause a more localized damage predominantly affecting the ocular surface, in comparison to chemical burns, where the agent may penetrate the surface and damage the intraocular structures, also causing glaucoma, thus limiting functional success. [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

“…Around 50% of patients with an indication for OOKP had preexisting glaucoma. [ 25 , 26 ] The highest incidence of de novo glaucoma following implantation was reported by Iannetti et al ,[ 23 ] where 66% eyes developed glaucoma postoperatively. Assessment of glaucoma is difficult in these eyes, as evidence of the disease on visual field examination is seen only during the advanced stages.…”

Section: The Modified Ookpmentioning

confidence: 99%

“…Compared to other Kpro designs, there was a relatively low incidence of endophthalmitis (0–8%) among all the studies reviewed. [ 21 , 23 ]…”

Section: The Modified Ookpmentioning

confidence: 99%

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Keratoprosthesis in dry eye disease

Sharma

Donthineni²,

Iyer³

et al. 2023

Indian Journal of Ophthalmology

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Bilateral corneal blindness with severe dry eye disease (DED), total limbal stem cell deficiency with underlying corneal stromal scarring and vascularization, combined with adnexal complications secondary to chronic cicatrizing conjunctivitis is a highly complex situation to treat. In such eyes, procedures such as penetrating keratoplasty alone or combined with limbal stem cell transplantation are doomed to fail. In these eyes, keratoprosthesis (Kpro) or an artificial cornea is the most viable option, eliminating corneal blindness even in eyes with autoimmune disorders such as Stevens–Johnson syndrome, ocular mucous membrane pemphigoid, Sjogren’s syndrome, and nonautoimmune disorders such as chemical/thermal ocular burns, all of which are complex pathologies. Performing a Kpro in these eyes also eliminates the need for systemic immunosuppression and may provide relatively early visual recovery. In such eyes, the donor cornea around the central cylinder of the Kpro needs to be covered with a second layer of protection to avoid desiccation and progressive stromal melt of the underlying cornea, which is a common complication in eyes with severe DED. In this review, we will focus on Kpro designs that have been developed to survive in eyes with the hostile environment of severe DED. Their outcomes in such eyes will be discussed.

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“…[ 12 , 14 ] Compared to previous studies, Iannetti et al . [ 23 ] reported a higher retention rate of 99% at 20 years and 94% at 30 years. De la Paz et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: The Modified Ookpmentioning

confidence: 99%

“…Compared to other Kpro designs, there was a relatively low incidence of endophthalmitis (0–8%) among all the studies reviewed. [ 21 , 23 ]…”

Section: The Modified Ookpmentioning

confidence: 99%

See 3 more Smart Citations

Keratoprosthesis in dry eye disease

Sharma

Donthineni²,

Iyer³

et al. 2023

Indian Journal of Ophthalmology

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Mimicking the Physicochemical Properties of the Cornea: A Low-Cost Approximation Using Highly Available Biopolymers

Hernández,

Panadero-Medianero,

Arrázola

et al. 2024

Polymers

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Corneal diseases represent a significant global health challenge, often resulting in blindness, for which penetrating keratoplasty is the clinical gold standard. However, in cases involving compromised ocular surfaces or graft failure, osteo-odonto keratoprosthesis (OOKP) emerges as a vital yet costly and complex alternative. Thus, there is an urgent need to introduce soft biomaterials that mimic the corneal tissue, considering its translation’s physicochemical, biological, and economic costs. This study introduces a cross-linked mixture of economically viable biomaterials, including gelatin, chitosan, and poly-D-lysine, that mimic corneal properties. The physicochemical evaluation of certain mixtures, specifically gelatin, chitosan, and poly-D-lysine cross-linked with 0.10% glutaraldehyde, demonstrates that properties such as swelling, optical transmittance, and thermal degradation are comparable to those of native corneas. Additionally, constructs fabricated with poly-D-lysine exhibit good cytocompatibility with fibroblasts at 72 h. These findings suggest that low-cost biopolymers, particularly those incorporating poly-D-lysine, mimic specific corneal characteristics and have the potential to foster fibroblast survival. While further studies are required to reach a final corneal-mimicking solution, this study contributes to positioning low-cost reagents as possible alternatives to develop biomaterials with physicochemical properties like those of the human cornea.

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