Osteo‐modulatory dietary proteins and peptides: A concise review

Okagu, Innocent Uzochukwu; Aham, Emmanuel Chigozie; Ezeorba, Timothy Prince Chidike; Ndefo, Joseph Chinedum; Aguchem, Rita Ngozi; Udenigwe, Chibuike C.

doi:10.1111/jfbc.14365

Cited by 6 publications

(3 citation statements)

References 164 publications

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“…Several pathways control the bone systems, foremost the collapse of older bone tissues through osteoclast genesis and then the formation of new bone tissues by osteoblast genesis (Okagu et al, 2022). Uncontrollable bone-related complications like osteoporosis, osteoarthritis, rheumatoid arthritis, bone cancer, and many other bone disorders are instigated by an interruption in these pathways (Barnsley et al, 2021).…”

Section: Bone and Joint Healthmentioning

confidence: 99%

Plant protein-derived peptides: frontiers in sustainable food system and applications

Nirmal,

Khanashyam,

Shah

et al. 2024

Front. Sustain. Food Syst.

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Plant proteins have been considered a potential source of bio-functional peptides, which can be beneficial for human health. The potent antioxidant properties of plant-based peptides protect against oxidative damage and associated diseases. Despite a significant number of studies on the preparation and biological functions of plant-based peptides, only a limited number of peptides are commercially utilized. The systematic studies of the extraction, optimization, isolation, pharmacokinetics, stability, and safety aspects of plant protein-derived peptides (PPDP) are in progress. Also, the molecular mechanism of action and health benefits of bioactive PPDP is still lacking. Hence, this review provides a comprehensive discussion of various plant protein sources to end-product applications of PPDP. In this context, different plant sources explored for functional and bioactive PPDP have been presented. The green biotechnological techniques such as fermentation and enzymatic hydrolysis for extraction of PPDP have been described. The functional and biological properties of PPDP have been revisited. The most important part of the application which includes the stability and bioavailability of PPDP has been discussed. Additionally, the health impact of PPDP administration has been summarized. Lastly, future perspectives and concluding remarks have been documented.

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Section: Bone and Joint Healthmentioning

confidence: 99%

Plant protein-derived peptides: frontiers in sustainable food system and applications

Nirmal,

Khanashyam,

Shah

et al. 2024

Front. Sustain. Food Syst.

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show abstract

“…Moreover, bone remodeling is a complex process involving several hormones, including estrogen ( 16 , 17 ). Osteoporosis refers to a condition in which bone mass decreases and bone structure deteriorates, weakening bone strength and increasing susceptibility to fractures ( 18 , 19 ). Considering that estrogen regulates bone metabolism, osteoporosis is more likely to occur following menopause-associated decrease in estrogen, a condition called postmenopausal osteoporosis ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Blackcurrant extract promotes differentiation of MC3T3‑E1 pre‑osteoblasts

Nanashima,

Horie,

Oey

2024

Biomed Rep

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Osteoporosis risk increases in menopausal individuals owing to the decrease in estrogen secretion. Blackcurrant extract (BCE) ameliorates osteoporosis; however, the underlying mechanisms are unclear. Furthermore, although BCE has phytoestrogenic activity, its effects on osteoblasts are unknown. In the present study, we investigated BCE-mediated attenuation of osteoporosis using mouse MC3T3-E1 pre-osteoblasts, with a focus on osteogenesis. After treating MC3T3-E1 cells with BCE for 48 h, cell proliferation was assessed using Cell Counting Kit-8. Levels of osteoblast differentiation markers, namely alkaline phosphatase activity and total collagen content in the cells, were evaluated after 3 and 14 days of BCE treatment, respectively. The expression of genes encoding osteoblast differentiation markers, including collagen type I ( Col-I ), alkaline phosphatase ( Alp ), bone γ-carboxyglutamate protein ( Bglap ), and runt-related transcription factor 2 ( Runx2 ), was evaluated using reverse transcription-quantitative polymerase chain reaction. Mineralization of the cells was evaluated using Alizarin Red staining. Femoral tissues of ovariectomized (OVX) rats with or without 3% BCE were stained using ALP to evaluate osteogenic differentiation in femoral tissue. After treating MC3T3-E1 cells with BCE, cell proliferation had increased. BCE treatment increased Alp activity and total collagen content. Moreover, the expression of Col-I , Alp , Bglap , and Runx2 increased in BCE-treated cells. Furthermore, when MC3T3-E1 cells were treated with BCE for 21 days, the levels of calcified nodules increased. Alp staining intensity was stronger in the epiphyses on femoral tissue of OVX rats treated with 3% BCE than in those of untreated OVX rats. The results suggest that BCE may promote osteogenesis by inducing osteoblast differentiation.

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“…Moreover, bone remodeling is very complex, involving multiple hormones such as estrogen [16,17]. Osteoporosis refers to a condition in which bone mass decreases and bone structure deteriorates, weakening bone strength and increasing susceptibility to fractures [18,19]. As estrogen regulates bone metabolism, osteoporosis is more likely to occur when estrogen levels decrease during menopause in a process called postmenopausal osteoporosis [20].…”

Section: Introductionmentioning

confidence: 99%

Blackcurrant extract promotes the differentiation of MC3T3-E1 pre-osteoblasts

Nanashima

Horie

Oey

2023

Preprint

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Background The risk of developing osteoporosis in menopausal women increases as estrogen secretion decreases. Blackcurrant extract (BCE) has been reported to ameliorate osteoporosis; however, the mechanisms underlying this phenomenon are unclear. Furthermore, although BCE has phytoestrogenic activity, its effects on osteoblasts are unknown. In this study, mouse pre-osteoblast MC3T3-E1 cells were used to investigate BCE-mediated attenuation of osteoporosis, with a focus on osteogenesis. Methods and Results After treating MC3T3-E1 cells with BCE for 48 h, the total number of cells was counted, and no conspicuous differences were observed. The levels of osteoblast differentiation markers, alkaline phosphatase activity, and total collagen content increased in BCE-treated cells on days 3–14. Additionally, the expression of genes encoding osteoblast differentiation markers, including collagen type I, alkaline phosphatase, osteocalcin, and runt-related transcription factor 2, increased in BCE-treated cells. At 21 days of treatment, calcified nodule levels were increased. Conclusions These findings show that BCE may promote osteogenesis by inducing osteoblast differentiation.

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Osteo‐modulatory dietary proteins and peptides: A concise review

Cited by 6 publications

References 164 publications

Plant protein-derived peptides: frontiers in sustainable food system and applications

Plant protein-derived peptides: frontiers in sustainable food system and applications

Blackcurrant extract promotes differentiation of MC3T3‑E1 pre‑osteoblasts

Blackcurrant extract promotes the differentiation of MC3T3-E1 pre-osteoblasts

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