Osteitis fibrosa

Knaggs, R. Lawford

doi:10.1002/bjs.1800104009

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Another particular type of OF is the brown tumour (BT) that is formed at an end stage of hyperparathyroidism (HPT) 40 and CKD 41 . Brown tumours (BTs) are generally multiple cystlike lytic lesions 42 that represent reparative granulomas 33 that may be present anywhere in the skeleton 43,44 . An excessive secretion of PTH leads to OF and BT in order to partially restore serum calcium levels to normal 45,46 .…”

Section: Brown Tumour (Bt)mentioning

confidence: 99%

Hibernation, puberty and chronic kidney disease in troglodytes from Spain half a million years ago

Bartsiokas

Arsuaga

2018

Preprint

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Both animal hibernation (heterothermy) and human renal osteodystrophy are characterized by high levels of serum parathyroid hormone. To test the hypothesis of hibernation in an extinct human species, we examined the hominin skeletal collection from Sima de los Huesos, Cave Mayor, Atapuerca, Spain, for evidence of hyperparathyroidism. We studied the morphology of the fossilized bones by using macrophotography, microscopy, histology and CT scanning. We found trabecular tunneling and osteitis fibrosa, subperiosteal resorption,‘rotten fence post’ signs,brown tumours, subperiosteal new bone, chondrocalcinosis, rachitic osteoplaques and empty gaps between them, craniotabes, and beading in ribs mostly in the adolescent population of these hominins. Since many of the above lesions are pathognomonic, these extinct hominins suffered annually from renal rickets, secondary hyperparathyroidism, and renal osteodystrophy associated with Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). We suggest these diseases were caused by non-tolerated hibernation in dark cavernous hibernacula. This is evidenced by the rachitic osteoplaques and the gaps between them mainly in the adolescent individuals along with the evidence of healing mainly in the adults. The sublayers in the rachitic osteoplaques point to bouts of arousal from hibernation. The strong projection of the external lip of the femoral trochlea, the rachitic osteoplaques with the empty gaps between them,the “rotten fence post sign”, and the evidence of annual healing caused by non-tolerated hibernation in adolescent individuals, also point to the presence of annually intermittent puberty in this population. The hypothesis of hibernation is consistent with the genetic evidence and the fact that the SH hominins lived during a glacial period. The present work will provide a new insight into the physiological mechanism of early human metabolism which could help in determining the life histories and physiologies of extinct human species.

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Section: Brown Tumour (Bt)mentioning

confidence: 99%

Hibernation, puberty and chronic kidney disease in troglodytes from Spain half a million years ago

Bartsiokas

Arsuaga

2018

Preprint

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A case of osteitis fibrosa (with formation of hyaline cartilage)

Telford

1931

British Journal of Surgery

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WHILST i t is hardly pmsible to add anything useful to the very completc review of this disease by Lawford Knaggsl and the brilliant monograph of Dawson and Struthers,2 the following case seems worthy of record, not only on account of its long history and the very gross changes which appear in the bone, but also because it shows the formation of hyaline cartilage in considerable masses. This formation of hyaline cartilage in osteitis fibrosa is rare, and to this feature I have not been able to find in a search of the already very extensive literature anything more than the scantiest reference\. B l o~d g o o d ,~ referring t o cysts in osteitis fibrosa, says, " i n a few of thcse eases, here and there, islands of cartilage are found ". Elmslie4 states that cartilage occurs in small patchcs ; " it may be hyaline, but is more often fibrous ". CASE REPORT.HwroRY.-The patient was a woman, age 34 years, who came to the Manchester Royal Infirmary in June, 1930, begging for the amputation of her left leg, which she said was useless and painful. She stated that she was well until she suffered a fracture of the left thigh bone twenty years before. This fracture does not appear to have been radiographed, and after treatment it united well. Two years later she noticed a swelling of the shin bone, and found that the limh was becoining shorter than its fellow. This condition grew gradually worse until the left lower limb was short by no less than fire inches.02; ExAMIhTATIos.-The limb presented a striking picture ; the shortening of five inches was found to lie entirely in the femur, the left thigh being stunted, wasted, and marked by deep transverse creases of redundant skin. The tibia was of normal length, but was uniformly enlarged in a fusiforni fashion reminiscent of the lower portion of an Indian club. Movements of the knee-and ankle-joints were normal, but the range of the hip-joint was slightly limited in all directions, more especially in abduction. The patient used the limb in walking, but only with difficulty and for short distances ; she complained of constant aching pain.A routine examination showed that the patient was otherwise healthy. No focus of sepsis was to be discovered; the Wassermann reaction was negative. The hlood-calcium was normal, and in her thin and very easily palpated neck there was no sign of any thyroid or parathyroid enlargement.

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Hibernation in hominins from Atapuerca, Spain half a million years ago

Bartsiokas

Arsuaga

2020

L'Anthropologie

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Osteitis fibrosa

Cited by 3 publications

References 2 publications

Hibernation, puberty and chronic kidney disease in troglodytes from Spain half a million years ago

Hibernation, puberty and chronic kidney disease in troglodytes from Spain half a million years ago

A case of osteitis fibrosa (with formation of hyaline cartilage)

Hibernation in hominins from Atapuerca, Spain half a million years ago

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