Osteitis and paranasal sinus inflammation

Georgalas, Christos

doi:10.1097/moo.0b013e32835ac656

Cited by 29 publications

(38 citation statements)

References 22 publications

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“…Of note, previous surgery has been associated with worsened osteitis scores in several studies, suggesting osteitis may be a marker of more severe disease and/or possibly a reaction to previous surgery. 386,399,401,402 The causality and relationship of bacterial biofilms, mucosal pathology, and bacterial infection is not well understood in relationship to osteitis. Bacterial infection of the bone is an unlikely cause of osteitis in CRS patients.…”

Section: S55mentioning

confidence: 99%

“…401 Single photon emission CT (SPECT) has been suggested as another modality, but is costly, not readily available, and exposes the patient to larger doses of radiation. 401,402 A variety of grading systems using CT imaging have also been proposed, including the Kennedy Osteitis Score, Global Osteitis Scoring Scale (GOSS), scoring based upon Hounsfield units (HU), thickness of bony partitions, as well as systematic examinations of separate reference points in the sinuses. 387,389,392,403,404 As with diagnostic testing for osteitis, these grading systems have not been standardized.…”

Section: S55mentioning

confidence: 99%

“…[384][385][386]401,402 CT imaging offers availability, good bony detail, and excellent sensitivity and specificity for detecting mucosal abnormalities and thickening. 401 Single photon emission CT (SPECT) has been suggested as another modality, but is costly, not readily available, and exposes the patient to larger doses of radiation.…”

Section: S55mentioning

confidence: 99%

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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: S55mentioning

confidence: 99%

Section: S55mentioning

confidence: 99%

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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

554

888

View full text Add to dashboard Cite

show abstract

“…Osteitis has been recognized as a potential confounding factor in the outcome of CRS treatment. Numerous studies have found an association between the presence of severe osteitis and disease extension using endoscopic scores such as the Lund-Mackay score [33,35,36]. However, no significant differences have been found in the quality of life in patients with and without osteitis [33,35].…”

Section: Extent Of Disease At Baseline and Comorbiditiesmentioning

confidence: 97%

“…On the CT scan, the osteitic bone appears as heterogeneous, irregular bone with areas of growth and destruction [35]. Osteitis has been recognized as a potential confounding factor in the outcome of CRS treatment.…”

Section: Extent Of Disease At Baseline and Comorbiditiesmentioning

confidence: 99%

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

López-Chacón

Mullol

Pujols

2015

Curr Allergy Asthma Rep

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Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled by treatment and have a poor quality of life. It is highly important to identify both clinical and biological markers, so-called biomarkers, in this subset of patients. The presence of nasal polyps and comorbidity with asthma and with aspirin-exacerbated respiratory disease (AERD) are the most common clinical traits that have been associated to difficult-to-treat severe CRS. In addition to clinical traits, numerous biological markers, with known etiopathogenic roles in CRS, have been associated to difficult-to-treat or recalcitrant CRS. This review summarizes the existing knowledge of the clinical and biological markers associated to difficult-to-treat or uncontrolled severe CRS.

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