2007
DOI: 10.1111/j.1440-1673.2007.01795.x
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Ossifying pleomorphic adenoma of the parotid gland: A case report and review

Abstract: Pleomorphic adenoma is the most common parotid gland neoplasm and occasionally arises from the deep lobe of the parotid gland with extension into the parapharyngeal space. However, ossification of pleomorphic adenoma is rare, although chondroid and myxochondroid tissue formation is frequently seen histologically. We report an unusual case of ossifying pleomorphic adenoma arising from the deep lobe of the parotid gland in the parapharyngeal space.

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Cited by 11 publications
(7 citation statements)
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“…In some cases an important chondroid matrix was present with the formation of enchondral ossification at the borders. 9 Others described the formation of osteoid indicating a possible direct differentiation from myoepithelial cells 10,11 Osseous metaplasia can also be found in carcinoma ex pleomorphic adenoma 12,13 and mixed tumour of the skin. 14,15 …”
Section: Discussionmentioning
confidence: 99%
“…In some cases an important chondroid matrix was present with the formation of enchondral ossification at the borders. 9 Others described the formation of osteoid indicating a possible direct differentiation from myoepithelial cells 10,11 Osseous metaplasia can also be found in carcinoma ex pleomorphic adenoma 12,13 and mixed tumour of the skin. 14,15 …”
Section: Discussionmentioning
confidence: 99%
“…There are some limitations to this investigation including the absence of a detailed analysis of the components of the calcific components, the difficulty of determining the exact mechanism of formation of all calcific foci, and the correlation between the multiple calcifications and the meningioma. Differential diagnosis of this present case could include pleomorphic adenoma, soft tissue chondroma or osteoma, extracranial meningioma, osteocartilaginous tumors arising from bone exostoses, [37] vascular ossification of atherosclerotic lesions, or hereditary conditions such as Albright's syndrome and fibrodysplasia ossificans progressive. [38] In the present case, the patient was referred to an ENT surgeon and a Neurosurgeon to exclude any possible malignancies.…”
Section: Discussionmentioning
confidence: 98%
“…Furthermore, whether this ossification is endochondral, originating from a cartilaginous precursor, or due to direct deposition by metaplastic myoepithelial cells within the tumor remains unclear. Multiple reports support both theories [ 7 9 ].…”
Section: Discussionmentioning
confidence: 98%