Ossifying fibromyxoid tumour of soft parts, with focus on unusual clinicopathological features

Holck, Susanne; Pedersen, John Gregor; Ackermann, Travis; Daugaard, Søren

doi:10.1046/j.1365-2559.2003.01623.x

Cited by 18 publications

(16 citation statements)

References 25 publications

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“…In this case, the finding of an encapsulated lobulated tumor of eosinophilic spindly cells with vesicular nuclei is as described by previously reported cases [1,[4][5][6] . Although the fibromyxoid component of OFMT might suggest a fibroblastic origin, the expression of both S100 and NSE proteins by the tumor cells point instead to a neural origin [1] .…”

Section: Discussionsupporting

confidence: 80%

“…Although the fibromyxoid component of OFMT might suggest a fibroblastic origin, the expression of both S100 and NSE proteins by the tumor cells point instead to a neural origin [1] . Further support for a neural histogenesis is provided by the discovery of Holck et al [6] of an interrupted basal lamina, a Schwannian feature in some of the reported cases [1,3,7] , and the demonstration of cytogenetic abnormalities involving chromosomes 6 and 18 also resonated with a malignant peripheral nerve sheath tumor.…”

Section: Discussionmentioning

confidence: 88%

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Ossifying Fibromyxoid Tumor of Soft Parts

Al-Brahim

Dashti²

2008

Med Princ Pract

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Objective: To report a rare case of ossifying fibromyxoid tumor of soft tissue in Kuwait. Clinical Presentation and Intervention: A 60-year-old woman presented with a painless tumor, increasing in size and located in the left buttock, which had been present for an uncertain duration. The patient underwent an excisional biopsy. Pathological examination revealed a 7.5-cm well-circumscribed mass with a lobulated cut surface. Histologically, the tumor was encapsulated by an incomplete shell of lamellar bone. The tumor had variable cellularity, and, in areas, contained myxoid stroma. The tumor cells had eosinophilic cytoplasm with vesicular round-to-oval nuclei. Sparse mitoses were noted. Immunohistochemical stains demonstrated that the tumor cells expressed vimentin, S100 and neuron-specific enolase, with the latter expressed focally. Conclusion: To the best of our knowledge, this is the first case of ossifying fibromyxoid tumor of soft parts to be reported in Kuwait. Therefore, pathologists and clinicians should be aware of this tumor.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 88%

Ossifying Fibromyxoid Tumor of Soft Parts

Al-Brahim

Dashti²

2008

Med Princ Pract

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“…In addition to a few large series [1,[4][5][6][7], there are many case reports describing a single or a few cases [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Although the extremities, trunk, and head and neck are prevailing sites, unusual locations, such as the retroperitoneum and mediastinum, were also recognized [11,15,19].…”

Section: Discussionmentioning

confidence: 99%

“…Both tumors possess abundant fibromyxoid stroma and may show S-100 protein immunoreactivity. For the distinction, ultrastructural investigation seems to be useful, in that extraskeletal myxoid chondrosarcoma usually contains unique intraendoplasmic microtubules and lacks welldeveloped, reduplicated basal laminae [33], which seem, to the contrary, to be an invariable, unique feature of OFMT [1,5,6,10,14,18,20]. In spite of the diverse immunophenotype, ultrastructural features are quite homogeneous.…”

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confidence: 99%

Ossifying Fibromyxoid Tumor: Invariable Ultrastructural Features and Diverse Immunophenotypic Expression

Hirose

Shimada

Tani

et al. 2007

Ultrastructural Pathology

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Ossifying fibromyxoid tumor (OFMT) is a rare enigmatic soft tissue tumor, the origin of which is still uncertain. The authors report on 3 cases of OFMT arising in the trunk and head and neck regions of adults. Two recurred and one was suspected to have metastasis. All tumors consisted of multiple nodules, in which round or polygonal tumor cells were arranged in sheets or cords within a fibromyxoid background. Characteristic shell-like bone tissues were recognized in all tumors. Based on the grading system proposed by Folpe et al., 2 cases were designated as malignant OFMT and 1 as typical. In addition to S-100 protein, cytokeratin and neuronal markers (neurofilament, CD56 or CD57) were detected in 1 and 2 tumors, respectively. The salient and invariable ultrastructural features included reduplicated basal laminas, which seem to be crucial for the diagnosis.

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“…[23][24][25] This subcutaneous tumor usually occurs on the proximal extremities (or head and neck) of adult males, with a mean age of 47 years. On histologic examination, this lesion is situated in the subcutaneous tissue and has a fibrous capsule encircling lobules and fascicles of round to fusiform cells in a focally myxoid matrix.…”

Section: Discussionmentioning

confidence: 99%

Ossifying Plexiform Tumor: Report of Two New Cases

Walsh

Sangüeza²

2008

The American Journal of Dermatopathology

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Ossifying plexiform tumor is a cutaneous lesion that microscopically resembles cellular neurothekeoma but has abundant central ossification as the prominent feature and has only been previously described in a single case report. We detail 2 additional examples, both arising on the finger of adult women (36 and 76 years old). Clinically, the lesions were described as a raised flesh-colored "extraosseous" mass, averaging 1.1 cm in greatest dimension. Histological examination showed an unencapsulated well-delineated dermal tumor with thin fibrous bands separating lobules and fascicles of epithelioid to spindled cells that were embedded in a somewhat loose myxoid matrix. Present within the center of the lobules were large irregular foci of mature bone, some lined by osteoblasts. After excision, these lesions have not recurred or persisted in a limited follow-up duration (9 and 2 months). In concordance with the only other case report of a 30-year-old woman with a left thumb mass, ossifying plexiform tumor has occurred exclusively on the digits of adult women. Although it is possible that ossifying plexiform tumor could represent an ossifying variant of cellular neurothekeoma, we believe it is a lesion sui generis, and hope its recognition will allow for an accurate diagnosis and distinction from other cutaneous ossifying lesions.

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Ossifying fibromyxoid tumour of soft parts, with focus on unusual clinicopathological features

Abstract: Though a distinct entity, ossifying fibromyxoid tumour may exhibit a wider clinicopathological spectrum than generally recognized.

Cited by 18 publications

References 25 publications

Ossifying Fibromyxoid Tumor of Soft Parts

Ossifying Fibromyxoid Tumor of Soft Parts

Ossifying Fibromyxoid Tumor: Invariable Ultrastructural Features and Diverse Immunophenotypic Expression

Ossifying Plexiform Tumor: Report of Two New Cases

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