Ossifying fibromyxoid tumor of soft parts

Velasco-Pastor, A.M.; Martínez‐Escribano, Jorge; Gil-Mateo, M. P.; Quecedo-Estébanez, Esther; Fortea-Baixauli, J.M.; Aliaga‐Boniche, A.

doi:10.1111/j.1600-0560.1996.tb01315.x

Cited by 14 publications

(14 citation statements)

References 6 publications

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“…In addition to a few large series [1,[4][5][6][7], there are many case reports describing a single or a few cases [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Although the extremities, trunk, and head and neck are prevailing sites, unusual locations, such as the retroperitoneum and mediastinum, were also recognized [11,15,19].…”

Section: Discussionmentioning

confidence: 99%

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Ossifying Fibromyxoid Tumor: Invariable Ultrastructural Features and Diverse Immunophenotypic Expression

Hirose

Shimada

Tani

et al. 2007

Ultrastructural Pathology

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Ossifying fibromyxoid tumor (OFMT) is a rare enigmatic soft tissue tumor, the origin of which is still uncertain. The authors report on 3 cases of OFMT arising in the trunk and head and neck regions of adults. Two recurred and one was suspected to have metastasis. All tumors consisted of multiple nodules, in which round or polygonal tumor cells were arranged in sheets or cords within a fibromyxoid background. Characteristic shell-like bone tissues were recognized in all tumors. Based on the grading system proposed by Folpe et al., 2 cases were designated as malignant OFMT and 1 as typical. In addition to S-100 protein, cytokeratin and neuronal markers (neurofilament, CD56 or CD57) were detected in 1 and 2 tumors, respectively. The salient and invariable ultrastructural features included reduplicated basal laminas, which seem to be crucial for the diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Enzinger et al suggested Schwann cell derivation based on its immunoreactivity to S-100 protein and ultrastructural demonstration of basal lamina [1]. Many subsequent investigators supported their hypothesis, further demonstrating the expression of GFAP and CD57 (Leu-7) [7,10,12,15,[17][18][19][20]23].…”

Section: Discussionmentioning

confidence: 99%

Ossifying Fibromyxoid Tumor: Invariable Ultrastructural Features and Diverse Immunophenotypic Expression

Hirose

Shimada

Tani

et al. 2007

Ultrastructural Pathology

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“…9 To date, approximately 220 tumors have been published as OFTs. Most of these lesions have had classic morphology, 1,4,7,8,11,13,14,16,[21][22][23][24][25]28,30,32,34,[36][37][38][39][40][43][44][45][46][47]49 but more emphasis has recently been placed on the recognition of atypical and clinically malignant variants. 6,12,19,25,29,35,41,48,49 In 1 large series, it was suggested that either high nuclear grade or high cellularity in combination with a mitotic rate >2 mitoses per 50 HPFs predicts malignant behavior in OFT.…”

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confidence: 99%

Ossifying Fibromyxoid Tumor of Soft Parts—A Clinicopathologic and Immunohistochemical Study of 104 Cases With Long-term Follow-up and a Critical Review of the Literature

Miettinen

Finnell

Fetsch

2008

American Journal of Surgical Pathology

122

197

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Ossifying fibromyxoid tumor (OFT) is a unique soft tissue tumor of uncertain histogenesis. The majority of reported cases (approximately 220) have pursued a benign clinical course. However, recent literature has emphasized the existence of morphologically atypical and clinically malignant examples of this tumor and proposed guidelines for assessment of biologic potential. In the present study, we evaluated 104 cases of OFT from the Armed Forces Institute of Pathology, accessioned between the years 1970 and 2007. Herein, OFT was strictly defined as a tumor with lobular architecture, predominantly epithelioid cell morphology, a low level of atypia, corded and trabecular growth patterns, moderate amounts of myxocollagenous matrix, and often, focal peripheral metaplastic bone formation. Tumors that lacked conventional morphology were excluded. The exclusion group included cutaneous mixed tumors, low-grade fibromyxoid sarcomas, and extraskeletal osteosarcomas. The OFTs occurred in 64 men and 40 women with a median age of 50 years (range, 21 to 81 y). The tumor size ranged from 0.7 to 17 cm (median, 3 cm). The mitotic rate varied from 0 to 41 mitotic figures per 50 HPFs (median, 2/50 HPFs). Tumor cell nuclei typically contained small, distinct nucleoli, and necrosis was infrequent (11/104). The great majority of tumors (67/71, 94%) were positive for S100 protein, whereas only occasional examples had (focal) positivity for desmin, glial fibrillary acidic protein, and an AE1/AE3 keratin cocktail. Local recurrences were documented in 9 of 41(22%) living patients, usually 10 or more years after primary surgery, but there were no metastases. A mitotic rate of >2 mitotic figures/50 HPFs was a risk factor for local recurrence, but necrosis, tumor size, the presence of satellite nodules, and positive margins were not. When OFT is strictly defined by the criteria noted above, there is potential for local recurrence, but there seems to be little or no risk for metastasis.

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“…[23][24][25] This subcutaneous tumor usually occurs on the proximal extremities (or head and neck) of adult males, with a mean age of 47 years. On histologic examination, this lesion is situated in the subcutaneous tissue and has a fibrous capsule encircling lobules and fascicles of round to fusiform cells in a focally myxoid matrix.…”

Section: Discussionmentioning

confidence: 99%

Ossifying Plexiform Tumor: Report of Two New Cases

Walsh

Sangüeza²

2008

The American Journal of Dermatopathology

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Ossifying plexiform tumor is a cutaneous lesion that microscopically resembles cellular neurothekeoma but has abundant central ossification as the prominent feature and has only been previously described in a single case report. We detail 2 additional examples, both arising on the finger of adult women (36 and 76 years old). Clinically, the lesions were described as a raised flesh-colored "extraosseous" mass, averaging 1.1 cm in greatest dimension. Histological examination showed an unencapsulated well-delineated dermal tumor with thin fibrous bands separating lobules and fascicles of epithelioid to spindled cells that were embedded in a somewhat loose myxoid matrix. Present within the center of the lobules were large irregular foci of mature bone, some lined by osteoblasts. After excision, these lesions have not recurred or persisted in a limited follow-up duration (9 and 2 months). In concordance with the only other case report of a 30-year-old woman with a left thumb mass, ossifying plexiform tumor has occurred exclusively on the digits of adult women. Although it is possible that ossifying plexiform tumor could represent an ossifying variant of cellular neurothekeoma, we believe it is a lesion sui generis, and hope its recognition will allow for an accurate diagnosis and distinction from other cutaneous ossifying lesions.

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Ossifying fibromyxoid tumor of soft parts

Cited by 14 publications

References 6 publications

Ossifying Fibromyxoid Tumor: Invariable Ultrastructural Features and Diverse Immunophenotypic Expression

Ossifying Fibromyxoid Tumor: Invariable Ultrastructural Features and Diverse Immunophenotypic Expression

Ossifying Fibromyxoid Tumor of Soft Parts—A Clinicopathologic and Immunohistochemical Study of 104 Cases With Long-term Follow-up and a Critical Review of the Literature

Ossifying Plexiform Tumor: Report of Two New Cases

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