Ossification of thoracic ligamenta flava

Kudo, S; Ono, Michikazu; Russell, W. A.

doi:10.2214/ajr.141.1.117

Cited by 78 publications

(48 citation statements)

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“…Currently, there is no comprehensive data on the epidemiological distribution of OLF, which produces some difficulties in the etiological studies of OLF. Kudo et al [15] observed 1,744 people using lateral chest X-rays, with a prevalence rate for OLF in males of 6.2, and 4.8 % in females. Guo et al [3] studied 1,768 volunteers using MRI and found a prevalence rate of 3.8 %.…”

Section: Imaging Methodsmentioning

confidence: 99%

“…Subjects of previous OLF studies were normal populations [15], volunteers [3], or clinical patients presenting with other symptoms [17]. The sample size of studies in normal population (1,744 persons) and volunteers (1,768) was The overall prevalence rate for men and women, *P = 0.001 large, but the methods used were lateral chest X-ray and MRI, with a poor sensitivity.…”

Section: Sample Selectionmentioning

confidence: 99%

“…OLF is one of the commonest causes of thoracic spinal stenosis and spinal cord compression, which can cause serious neurological symptoms or even paraplegia. Currently, the etiology and epidemiological characteristics of OLF are unknown and epidemiological investigations using diagnostic imaging methods have rarely been performed [3,15]. Diagnostic methods were lateral radiographs [15] or MRI scans [3], but there are many factors that can contribute to local spinal bone overlaps in the lateral chest radiograph, which is not sensitive enough to identify the tiny areas of OLF.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, the etiology and epidemiological characteristics of OLF are unknown and epidemiological investigations using diagnostic imaging methods have rarely been performed [3,15]. Diagnostic methods were lateral radiographs [15] or MRI scans [3], but there are many factors that can contribute to local spinal bone overlaps in the lateral chest radiograph, which is not sensitive enough to identify the tiny areas of OLF. MRI is less sensitive for the observation of ossification, which can be found only when the regions of ossification are round, triangular, or bulky, with low signal intensity and protruding into the vertebral canal, thus compressing the dural sac [6,16].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological survey of ossification of the ligamentum flavum in thoracic spine: CT imaging observation of 993 cases

et al. 2012

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Objective To investigate the characteristics of epidemiological distribution of the ossification of the ligamentum flavum (OLF) in the thoracic spine including the incidence, segmental distribution, and shape. Methods Chest spiral computed tomography scans of 993 cases (male 506, female 487, mean age 60 years, range 5-102 years) who presented due to chest symptoms were analyzed with axial slices combined with sagittal slices. The conditions of OLF in the thoracic spine, including segments, thickness, location, and dural sac compression, were recorded. Prevalence was standardized according to the ''Age Structure of Population in Beijing 2008''. Results Among the population investigated, the standardized prevalence rate was 63.9 %. The standardized prevalence rate for males (68.5 %) was higher than that for females (59.0 %). The highest prevalence rate of OLF was in the 50-59 years age group (79.2 %); however, high density originated it can be found in individuals aged 10-19 years. The comparison of different thoracic segments showed that T10-11 (44.0 %) and T11-12 (41.6 %) had the highest prevalence rates. ConclusionThe prevalence of ossification of the ligamentum flavum was highest in the 50-59 years group, but also occurred in early years. OLF occurs more frequently in the lower than in the upper and middle thoracic regions and its prevalence increases with aging.

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Section: Imaging Methodsmentioning

confidence: 99%

Section: Sample Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiological survey of ossification of the ligamentum flavum in thoracic spine: CT imaging observation of 993 cases

et al. 2012

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“…TOLF is rare and usually asymptomatic [1]. In a survey of radiographic findings conducted in Japan, the prevalence of asymptomatic thoracic and lumbar OLF in adults was as high as 6.2% for men and 4.8% for women [8,10]. The disease usually has an insidious onset and a slow progression [1,9].…”

Section: Discussionmentioning

confidence: 99%

Chest Discomfort Secondary to Ossification of the Ligamentum Flavum of the Thoracic Spine: A Case Report

Lee¹,

Kang²,

Lee³

et al. 2017

J Spine

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Symptomatic thoracic ossification of the ligamentum flavum is rare, and a modality for its treatment has not yet been fully established; most reported patients complained of myelopathy. Herein, the authors will report on an extremely rare presentation of thoracic ossification of the ligamentum flavum, along with clinical outcomes. The patient complained of chest discomfort and myelopathy symptoms for 1 year secondary to thoracic ossification of the ligamentum flavum. He underwent one surgical procedure. Postoperatively, his symptoms such as chest discomfort and myelopathy improved completely. As of this report, the patient has had a good postoperative recovery, had good overall health, and adapted well to his social activities.

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M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway

Yang,

Chen,

Fan

et al. 2023

JOR Spine

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BackgroundM1 macrophages (Mφs) are involved in osteogenic differentiation of ligamentum flavum (LF) cells and play an important role in heterotopic ossification. However, the mechanism by which M1 Mφs influence osteogenic differentiation of LF cells has not been studied.MethodsThe effect of conditioned medium including secretions of M1 Mφs (CM‐M1) on LF cells was analyzed by GeneChip profiling and ingenuity pathway analysis (IPA). THP‐1 cells were polarized into M1 Mφs and CM‐M1 was used to induce LF cells. In addition, LF cells were induced by CM‐M1 in the presence of cyclooxygenase 2 (COX‐2) inhibitors or oncostatin M (OSM)‐neutralizing antibodies. Based on the presence of OSM, knockout of OSMR or GP130 receptors, or addition of the Janus kinase 2 (JAK2) inhibitor AZD1480 or signal transducer and activator of transcription 3 (STAT3) inhibitor Stattic were examined for effects on osteogenic differentiation of LF cells. OSM secretion was quantified by ELISA, while qPCR and western blot were used to evaluate expression of osteogenic genes and receptor and signaling pathway‐related proteins, respectively.ResultsGeneChip and IPA results indicate that the OSM signaling pathway and its downstream signaling molecules JAK2 and STAT3 are significantly activated. ELISA results indicate that OSM is highly expressed in cells treated with CM‐M1 and lowly expressed in cells treated with CM‐M1 and a COX‐2 inhibitor. Besides, CM‐M1 induces osteogenic differentiation of LF cells, which is weakened when COX‐2 inhibitors or OSM‐neutralizing antibody are added to it. Recombinant OSM could induce osteogenic differentiation of LF cells and upregulate expression of OSMR, GP130, phosphorylated (P)‐JAK2, and P‐STAT3. Upon knockdown of OSMR or GP130, or the addition of AZD1480 or Stattic, P‐JAK2 and P‐STAT3 expression were decreased and osteogenic differentiation was reduced.ConclusionM1 Mφ‐derived OSM induces osteogenic differentiation of LF cells and the JAK2/STAT3 signaling pathway plays an important role.

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Ossification of thoracic ligamenta flava

Cited by 78 publications

References 0 publications

Epidemiological survey of ossification of the ligamentum flavum in thoracic spine: CT imaging observation of 993 cases

Epidemiological survey of ossification of the ligamentum flavum in thoracic spine: CT imaging observation of 993 cases

Chest Discomfort Secondary to Ossification of the Ligamentum Flavum of the Thoracic Spine: A Case Report

M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway

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