Ossification of the posterior longitudinal ligament in three geographically and genetically different populations of ankylosing spondylitis and other spondyloarthropathies

Ramos-Remus, César; Russell, Anthony S.; Gomez-Vargas, Amparo; Hernández-Chávez, Abel; Maksymowych, Walter P.; Gámez-Nava, Jorge I.; González-López, Laura; García-Hernández, Alicia; Meoño-Morales, Esther; Burgos‐Vargas, Rubén; Suarez‐Almazor, María E.

doi:10.1136/ard.57.7.429

Cited by 38 publications

(17 citation statements)

References 33 publications

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“…54, 108 Resnick et al 109 found OPLL in 50% of patients with DISH. In 2009, Kawabori et al 51 reported a rare case of DISH with continuous-type OPLL at C2-4 that presented with cervical myelopathy from C-1 posterior tubercle impingement.…”

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confidence: 99%

Ossification of the posterior longitudinal ligament: a review

Saetia

Cho

Lee

et al. 2011

FOC

120

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Ossification of the posterior longitudinal ligament (OPLL) is most commonly found in men, the elderly, and Asian patients. There are many diseases associated with OPLL, such as diffuse idiopathic skeletal hyperostosis, ankylosing spondylitis, and other spondyloarthropathies. Several factors have been reported to be associated with OPLL formation and progression, including genetic, hormonal, environmental, and lifestyle factors. However, the pathogenesis of OPLL is still unclear. Most symptomatic patients with OPLL present with neurological deficits such as myelopathy, radiculopathy, and/or bowel and bladder symptoms. There are some reports of asymptomatic OPLL. Both static and dynamic factors are related to the development of myelopathy. Plain radiography, CT, and MR imaging are used to evaluate OPLL extension and the area of spinal cord compression. Management of OPLL continues to be controversial. Each surgical technique has some advantages and disadvantages, and the choice of operation should be made case by case, depending on the patient's condition, level of pathology, type of OPLL, and the surgeon's experience. In this paper, the authors attempt to review the incidence, pathology, pathogenesis, natural history, clinical presentation, classification, radiological evaluation, and management of OPLL.

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confidence: 99%

Ossification of the posterior longitudinal ligament: a review

Saetia

Cho

Lee

et al. 2011

FOC

120

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“…The inflammation resulting from incarceration of the cord [20] may also cause the increased thickness of dorsal arachnoid [17,21,22]. In addition, within several mechanisms suggested as cause of nervous system involvement in AS, inflammation and compression are the main causative mechanisms [23,24]. It has been illustrated in AS patients that the neurologic deficit might be caused by inflammation.…”

Section: Discussionmentioning

confidence: 99%

Thoracic spinal cord herniation in a patient with long-standing ankylosing spondylitis

et al. 2010

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The objective of this study was to describe an adult male patient with ankylosing spondylitis (AS) associated with thoracic spinal cord herniation (TSCH). TSCH is a scarce entity presented as a displacement of thoracic cord through an anterior or anterolateral dural defect. More importantly, the co-occurrence of AS and thoracic spinal cord herniation is exceptional. To date, only one case of SCH in association with AS has been reported in the literature. A 56-year-old male patient presented with the progressive difficulty in walking and numbness of both lower limbs for the past 18 months. The patient was diagnosed as AS when he was 30 years old. Sagittal MRI of thoracic spine showed dural defect of the posterior aspect of T11 and 12 vertebral bodies. Axial T2-weighted MRI demonstrated that spinal cord was displaced ventrally and to the right. The diagnosis of TSCH with AS was established. The prognosis was explained to the patient. We recommended duraplasty for dural repair to the patient, but he refused surgery. The results demonstrated that TSCH associated with long-standing AS was very uncommon, and MRI is recommended to rule out SCH in the long-standing AS patients with neurologic symptoms. The SCH in AS might be caused by inflammation, and thoracolumbar hyperkyphosis results from AS might be associated with the development of SCH.

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“…Pathophysiology of SSEP abnormalities is unknown; also it was recommended that caution should be exercised in interpreting delayed evoked potentials if multiple sclerosis is suspected in a patient with AS [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…Somatosensory evoked potentials were abnormal in 19 (63%) patients, and 9 patients (30%) had impaired function on brainstem auditory evoked potentials. Ramos-Remus et al [13] also reported abnormal SSEP findings in only 14.6% of their patients with AS.…”

Section: Introductionmentioning

confidence: 97%

Somatosensory Evoked Potential Findings in Ankylosing Spondylitis

Çidem

Sahin

Aydın

et al. 2014

EAJM

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Objective: Somatosensory evoked potential (SSEP) abnormalities were reported in patients with ankylosing spondylitis (AS). This study aimed to investigate SSEP abnormalities and its relation with clinical findings in AS patients. Materials and Methods:The study included 26 patients with AS and 17 age-matched health volunteers (Control for SSEP). Median nerve SSEP findings were normal in all AS cases.Results: However, delayed latency and/or very low amplitude of tibial nerve SSEP was found in 20 (76.9%) AS patients. There were significant correlations between tibial SSEP latency and disease duration (R=0.433 to 0.635). There was also an inverse correlation between tibial SSEP amplitude and disease duration (R=-0.429, p=0.047). Serum estradiol level, hip total bone mineral density, The Bath Ankylosing Spondylitis Functional Index (BASFI) score and Beck depression score were significantly lower in AS patients with SSEP abnormalities (37.3±10.8 pg/mL, 0.916±0.123 g/cm 2 , 35.0±27.9, 12.8±8.4, respectively) than in AS patients without SSEP abnormalities (53.7±12.3 pg/mL, 1.103±0.197 g/cm 2 , 64.8±15.5, 24.8±10.1, respectively). Conclusion:Significant inverse correlations between SSEP latencies and dehydroepiandrosterone sulphate (DHEAS) levels were found (R=-0.400 to -0.713). There were also significant inverse correlation between SSEP latencies and DHEAS/oestrogen index (R=-0.596 to -0.868), and between SSEP latencies and DHEAS/Progesterone index (R=-0.467 to -0.685). As a conclusion, this study indicates that tibial nerve SSEP abnormalities are common in patients with AS and there are significant correlations between clinical findings of AS and SSEP abnormalities. Sonuç: SUP latansları ve dihidroepiandrosteron sülfat (DHEAS) seviyeleri arasında anlamlı ters ilişki bulundu (R= (-0,400) -(-0,713)). SUP latansları ile DHEAS/östrojen indeksi ve DHEAS/progesterone indeksi arasında anlamlı ters ilişki bulundu (sırasıyla R=(-0,596) -(-0,868) ve R= (-0,467) -(-0,685)). Sonuç olarak AS'li hastalarda tibial SUP bozuklukları sıktır ve AS'nin klinik bulguları ile anlamlı ilişkiler vardır. AS'nin patogenez ve klinik bulguları üzerinde potansiyel nörolojik mekanizmaların etkisini araştıran daha fazla sayıda hasta içeren yeni araştır-malara ihtiyaç vardır.

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Ossification of the posterior longitudinal ligament in three geographically and genetically different populations of ankylosing spondylitis and other spondyloarthropathies

Cited by 38 publications

References 33 publications

Ossification of the posterior longitudinal ligament: a review

Ossification of the posterior longitudinal ligament: a review

Thoracic spinal cord herniation in a patient with long-standing ankylosing spondylitis

Somatosensory Evoked Potential Findings in Ankylosing Spondylitis

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