Osseous Metaplasia of the Eyelid

Abstract

Purpose To describe two unusual cases of osseous metaplasia occurring within the eyelid and to present a brief review of the literature on cutaneous calcification. Methods Case reports and literature review. Results A 62-year old man presented with an eyelid mass containing osseous metaplasia in an area of lymphoid hyperplasia. An extensive oncologic workup ruled out malignancy. A 46-year old man with a history of recurrent chalazion presented with a firm mass of the upper eyelid that demonstrated bone formation in the area of a metaplastic sebaceous gland. Both lesions were excised with no further recurrence. Conclusions Osseous metaplasia of the eyelid is a rare entity with diverse etiologies ranging from congenital syndromes to trauma, neoplasm, and inflammation. In some cases, a precise etiology cannot be identified.

Osseous Metaplasia of the Eyelid in a Child

“…Another illustrative case of bilateral intratarsal ossification associated with immunoglobulin light chain amyloid displayed prominent antecedent dystrophic calcification adjacent to the bone. 4 Given the focal longstanding nature of the illustrated eyelid lesion, it is reasonable to assume a precursor either in the form of a chalazion, in which ossification has been previously described, 1,5 or an intratarsal keratinous cyst, suggested by the concentric lamellae within the histopathology. While the lamellae could not be characterized by immunohistochemistry, it is possible that loss of antigenicity occurred over time.…”

“…Similar rare cases have not been reported to occur. 1,2,4 Abstract: A 46-year-old man with refractory migraine headache was treated with decompressive migraine surgery of the supraorbital and supratrochlear nerves. Postoperatively, he reported diplopia that got better on left head tilt.…”

“…M igraine is the second most common primary headache, and it affects approximately 15% of people in the general population. 1 It can be a severe and disabling condition. Migraine pathophysiology is still unclear, but it is widely accepted that activation and sensitization of the trigeminovascular pathways play significant roles.…”