Osseous Metaplasia of Juvenile Polyp

Deshmukh, V.V.; Jagdale, Abhijit; Dhake, Rahul; Naik, Deepak C

doi:10.7860/jcdr/2018/34017.11508

Cited by 2 publications

(3 citation statements)

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“…Overall, osseous metaplasia is a rare phenomenon in colonic polyps. To the best of our knowledge, there have been approximately 22 reported cases of osseous metaplasia in juvenile rectal polyps [3][4][5][6][7][8][9][10][11][12][13]. The average patient age at the time of diagnosis was 8.55 years, with the average largest polyp size being 13.68 mm.…”

Section: Discussionmentioning

confidence: 99%

A Case of Osseous Metaplasia in a Juvenile Rectal Polyp

Le,

Gonzalez

2024

Cureus

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Rectal mucosal prolapse is uncommon in children. While most patients present with rectal bleeding and constipation, the occurrence of osseous metaplasia within the prolapsed mucosa is extremely rare. Overlapping clinical, gross, and histological features between rectal mucosal prolapse polyps and malignancy pose a challenge for diagnoses. We describe a case of a 16-year-old male who had a rectal mucosal prolapsed polyp with osseous metaplasia. He initially presented due to periumbilical pain with a sore throat and fever. Incidentally, during the workup of his periumbilical pain, he was found to have a soft tissue mass in his rectum on a CT scan, with a biopsy confirming the diagnosis. The case was complicated by the development of sepsis. The patient was treated with empiric antibiotics and was discharged without further complications.

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Section: Discussionmentioning

confidence: 99%

A Case of Osseous Metaplasia in a Juvenile Rectal Polyp

Le,

Gonzalez

2024

Cureus

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“…Osseous metaplasia has also been observed in rectal cancer, often after neoadjuvant treatment, 45 and in inflammatory and juvenile polyps, 49,50 suggesting that inflammation is an important factor in ossification. In general, osseous metaplasia occurs when osteoblasts differentiate from fibroblasts secondary to persistent inflammation or tissue damage, or the release of substances such as bone morphogenetic proteins (BMPs) 46,47,50–52 . Local osteogenic factors such as BMPs often stimulate the osteoblasts to incorporate collagen fibres into new bone 52 .…”

Section: Osseous Metaplasiamentioning

confidence: 99%

“…In general, osseous metaplasia occurs when osteoblasts differentiate from fibroblasts secondary to persistent inflammation or tissue damage, or the release of substances such as bone morphogenetic proteins (BMPs). 46,47,[50][51][52] Local osteogenic factors such as BMPs often stimulate the osteoblasts to incorporate collagen fibres into new bone. 52 The phenomenon can also result from the interaction of local physiochemical factors such as calcium salts (calcium phosphate) with proliferating connective tissue.…”

Section: P a T H O P H Y S I O L O G Ymentioning

confidence: 99%

Incidental morphological findings in colorectal adenomas

2020

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Owing to a sharp increase in the frequency of diagnosis of colorectal adenomas in the current era of population screening, distinctive morphological features are increasingly being observed. These may present diagnostic challenges and cause clinical management issues. Paneth cell metaplasia is a more common occurrence, but the incidence rates of squamous metaplasia, clear cell metaplasia, osseous metaplasia, neuroendocrine differentiation and signet‐ring cell‐like lesion are low, and they can be seen in <1% of colorectal adenomas. Their histomorphological characteristics are quite unique; ancillary studies are not very helpful and often not needed. In this review, we give an overview and describe the potential clinical consequences of such incidental and special morphological findings in colorectal adenomas.

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Osseous Metaplasia of Juvenile Polyp

Cited by 2 publications

References 0 publications

A Case of Osseous Metaplasia in a Juvenile Rectal Polyp

A Case of Osseous Metaplasia in a Juvenile Rectal Polyp

Incidental morphological findings in colorectal adenomas

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