A female Cuvier's Beaked Whale (
Ziphius cavirostris
) specimen measuring 580 cm in length died after being stranded in Southeastern Brazil. Following a necropsy, organ samples were obtained, fixed in 10% neutral buffered formalin and histopathologically analyzed. A severe and generalized hypodermis infection by
Phyllobothrium delphini
(Phyllobothriidae) was observed, resulting in granulomatous panniculitis. Severe renal and arterial lesions were also noted, including a severe bone metaplasia in the aorta artery, associated with a massive infection by
Crassicauda
sp, (Tetrameridae). A significant thoracic hemorrhage due to thoracic aorta artery rupture was noted, also likely due to this infection, resulting in a fatal injury. This study contributes towards knowledge on histopathologic changes in the scarcely studied Cuvier's Beaked Whale, is the first to associate a
Crassicauda
sp. infection in this whale species in the Brazilian region and also the first to indicate a resulting osseous metaplasia due to this parasitism and granulomatous dermatitis associated with
Phyllobothrium delphini
. Furthermore, this is also, to the best of our knowledge, the first report of
Phyllobothrium delphini
cysts in a
Ziphius cavirostris
specimen to date.