Osseous Malformation in Baby Born to Woman on Cyclosporin

Pujals, Josep M.; Figueras, G.; Lloveras, J; Aubia, J; Masramon, J.

doi:10.1016/s0140-6736(89)92167-3

Cited by 22 publications

(11 citation statements)

References 9 publications

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“…A few isolated cases of minor abnormalities have been described, including osseous hypoplasia (leg and foot), a condition suggesting that CsA might interfere with osteoclast and obsteoblast differentiation [53].…”

Section: Azathioprinementioning

confidence: 99%

In utero exposure to immunosuppressive drugs: experimental and clinical studies

Tendron¹,

Jb²,

Decramer³

2002

Pediatric Nephrology

101

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Over the last few decades, the number of pregnant women under immunosuppressive (IS) therapy following transplantation or autoimmune diseases has increased. At first, IS drugs, including prednisone, azathioprine, and cyclosporine A were used, but now new molecules such as tacrolimus and mycophenolate mofetil have appeared. These IS drugs cross the placental barrier and enter into the fetal circulation, which poses a risk for fetal development. Experimental data have shown that IS drugs often have deleterious effects on fetuses, while human data have reported an increased rate of abortion, prematurity, intrauterine growth retardation (IUGR), and low birth weight, without significant increases in malformation rates. However, only limited information is available about the newly used molecules. Although fetal and neonatal data are reassuring, long-term effects of IS drugs on fertility, immune response and renal function, as well as the consequences of prematurity and IUGR, should be monitored.

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Section: Azathioprinementioning

confidence: 99%

In utero exposure to immunosuppressive drugs: experimental and clinical studies

Tendron¹,

Jb²,

Decramer³

2002

Pediatric Nephrology

101

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“…In Bezug auf eine Therapie mit Cyclosporin können keine validierten Empfehlungen gegeben werden, da nur wenig Daten zur Verfügung stehen. Es scheinen keine spezifischen kongenitalen Anomalien aufzutreten [27]. Selten sind Blutbildveränderungen des Feten beschrieben [28].…”

Section: Das Erkennen Von Risikopatientinnenunclassified

Interdisziplinäre Betreuung von schwangeren Patientinnen mit Kollagenosen

Wimmer

Oberhoffer²,

Schneider³

et al. 2004

Z Geburtshilfe Neonatol

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Connective tissue diseases affect frequently women during the childbearing period. As fertility is not considerably reduced in these patients, monitoring and treatment of a pregnant patient is a complex clinical setting that requires an intensive cooperation between gynecologists, rheumatologists and pediatricians. In this article, a 4-point-program for the clinical management of these patients is presented that addresses specifically the problems inherent with the identification of patients with connective tissue diseases, preconceptional diagnostics as well as monitoring and treatment during pregnancy and the postpartal period. Clinical aspects that are intensively discussed include immunosuppressive therapy during pregnancy, the management of antiphospholipid antibody-dependent problems and the prophylaxis and treatment options for congenital heart block.

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“…[84] Although no specific birth defect has been associated with cyclosporin, many sporadic congenital anomalies have been reported, including absence of the corpus callosum, cataracts, hypoparathyroidism and limb hypoplasia. [85] Most experts believe that cyclosporin is not associated with birth defects.…”

Section: Fetal Issuesmentioning

confidence: 99%

Immunosuppressive Drug Use in Pregnancy

Petri

2003

Autoimmunity

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Ideally, immunosuppressive drugs would not be necessary in pregnancy. However, in connective tissue disease (especially systemic lupus erythematosus, SLE) vasculitis, and sometimes antiphospholipid antibody syndrome, their use is necessary both to protect the health of the mother and to insure the success of the pregnancy. The more commonly used drugs will be reviewed, with an emphasis on human data, when available. Methotrexate and leflunamide will not be considered, for they should never be used in pregnancy.

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Osseous Malformation in Baby Born to Woman on Cyclosporin

Cited by 22 publications

References 9 publications

In utero exposure to immunosuppressive drugs: experimental and clinical studies

In utero exposure to immunosuppressive drugs: experimental and clinical studies

Interdisziplinäre Betreuung von schwangeren Patientinnen mit Kollagenosen

Immunosuppressive Drug Use in Pregnancy

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