Osseous Characteristics of Mice Lacking Cannabinoid Receptor 2 after Pulp Exposure

Nikolaeva, Elizabeth P.; Cox, Timothy C.; Flake, Natasha M.

doi:10.1016/j.joen.2015.01.030

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…Activating the CB-2 receptor was found to stimulate bone formation, balance bone remodeling, and perhaps play a protective role against age-related bone loss. 19,20 However, a clinical cross-sectional study of a group of 109 heavy cannabis users (comprised of mostly young men) showed that the heavy cannabis user group had substantially lower bone mineral density (BMD) Z-score values at the lumbar spine and hip evident on DEXA scans, and therefore concluded that heavy cannabis use may lead to an increased risk of fracture compared to non-heavy cannabis users. 21 Furthermore, a retrospective study that utilized the National Health and Nutrition Examination Survey from 2007 to 2010 investigated 4,743 participants between the age of 20 and 59 with self-reported history of cannabis use.…”

Section: Discussionmentioning

confidence: 99%

Cannabis Use Increases Risk for Revision After Total Knee Arthroplasty

Law

Kurowicki

Rosas

et al. 2018

J Long Term Eff Med Implants

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As an increasing number of states begin to legalize marijuana for either medical or recreational use, it is important to determine its effects on joint arthroplasty. The purpose of this study is to determine the impact of cannabis use on total knee arthroplasty (TKA) revision incidence, revision causes, and time to revision by analyzing the Medicare database between 2005 and 2014. A retrospective review of the Medicare database for TKA, revision TKA, and causes was performed utilizing Current Procedural Terminology (CPT) and International Classification of Disease ninth revision codes (ICD-9). Patients who underwent TKA were cross-referenced for a history of cannabis use by querying ICD-9 codes 304.30–32 and 305.20–22. The resulting group was then longitudinally tracked postoperatively for revision TKA. Cause for revision, time to revision, and gender were also investigated. Our analysis returned 2, 718,023 TKAs and 247,112 (9.1%) revisions between 2005 and 2014. Cannabis use was prevalent in 18,875 (0.7%) of TKApatients with 2,419 (12.8%) revisions within the cannabis cohort. Revision incidence was significantly greater in patients who use cannabis (p < 0.001). Time to revision was also significantly decreased in patients who used cannabis, with increased 30- and 90-day revision incidence compared to the noncannabis group (P < 0.001). Infection was the most common cause of revision in both groups (33.5% nonusers versus 36.6% cannabis users). Cannabis use may result in decreasing implant survivorship and increasing the risk for revision within the 90-day global period compared to noncannabis users following primary TKA.

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Section: Discussionmentioning

confidence: 99%

Cannabis Use Increases Risk for Revision After Total Knee Arthroplasty

Law

Kurowicki

Rosas

et al. 2018

J Long Term Eff Med Implants

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Activating the CB2 receptor stimulated bone formation, balanced bone remodeling, and perhaps played a protective role against age-related bone loss. 34 A clinical cross-sectional study of 109 heavy cannabis users (mostly young men) compared with non-heavy cannabis users showed substantially lower bone mineral density Z-score values at the lumbar spine and hip evident on dual-energy X-ray absorptiometry (DEXA) scans on the heavy cannabis users. 35 A recent review analyzed data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample database to evaluate the effect of marijuana use by orthopaedic patients on inpatient mortality, heart failure, stroke, and cardiac disease.…”

Section: Cannabis Usage and Implicationsmentioning

confidence: 99%

Patient Experience and Perspective on Medical Cannabis as an Alternative for Musculoskeletal Pain Management

et al. 2022

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Introduction: The current rate of opioid prescription is disquieting because of their high abuse potential, adverse effects, and thousands of overdose deaths. This situation imposes urgency in seeking alternatives for adequate pain management. From this perspective, this study aimed to evaluate the experience and the perceived analgesic efficacy of medical cannabis in managing the pain associated with musculoskeletal conditions. Methods: A 28-question survey was distributed to patients at a major medical cannabis center in Puerto Rico for 2 months. Demographics, medical history, cannabis usage, cannabis use perspective, and analgesic efficacy were assessed in the questionnaire. Results: One hundred eighty-four patients completed our survey. The majority (67%) were males, and the participants' average age was 38 years. This study showed an average pain reduction score of 4.02 points on the Numeric Rating Scale among all the participants. Those with musculoskeletal conditions reported a notable average pain reduction score of 4.47 points. In addition, 89% of the participants considered medical cannabis to be more effective than narcotics for adequate pain management. Conclusions: This study demonstrated that the use of medical cannabis among patients with musculoskeletal conditions effectively reduced pain levels based on their Numeric Rating Scale reported scores.

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“…After AP induction, KO mice for IL6, 7 OPN, 8 iNOS, 9 TLR22, 10 IL17RA; 11 MyD88 12 and MMP9 13 developed more severe AP than wild-type mice; on the other hand, KO mice for IL22 32 and for CB2 33 developed less severe AP. Animals deficient in PHOX, which mediates the generation of reactive oxygen species, did not present alterations in the AP phenotype.…”

Section: Literature Search Strategymentioning

confidence: 97%

“…List of candidate genes, in alphabetic order, based on the animal knockout (KO) model studies. CB2 Nikolaeva et al (2015)33 The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors and are located in immune cells.…”

mentioning

confidence: 99%

Current trends of genetics in apical periodontitis research

et al. 2018

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Genetics is an emerging topic in endodontic research focusing on the host response regarding the pathogenesis of apical periodontitis (AP). A number of genetic epidemiological studies carried out by many investigators worldwide have shown evidence of an association between certain candidate genes and AP. Some studies have been conducted on knockout mice with a deficiency in certain proteins, leading to more or less severe AP, and thus suggesting a pivotal role of these genes in AP pathogenesis. Other research has evaluated the association between genetic polymorphisms in humans with different AP aspects; these studies pointed out that genetic polymorphisms in some candidate genes are involved in inter-individual variations in their response to AP. Therefore, the objective of this report was to provide an updated overview of the genes involved in AP pathogenesis, with a focus on the most relevant candidate genes.

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Osseous Characteristics of Mice Lacking Cannabinoid Receptor 2 after Pulp Exposure

Cited by 7 publications

References 28 publications

Cannabis Use Increases Risk for Revision After Total Knee Arthroplasty

Cannabis Use Increases Risk for Revision After Total Knee Arthroplasty

Patient Experience and Perspective on Medical Cannabis as an Alternative for Musculoskeletal Pain Management

Current trends of genetics in apical periodontitis research

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