Osseous avascular necrosis associated with systemic abnormalities

Aseptic osteonecrosis in children treated for acute lymphoblastic leukemia and aplastic anemia

“…For example, excessive endogenous overproduction of corticosteroids has been associated with bone necrosis [13]. Osteonecrosis has been reported in particular after prolonged therapeutic administration of corticosteroids by numerous observers [1,4,9,11,18,24). This is well examplified by patient A.M. who has received a total dose of 2.2 g of prednisone over a period of 9 months for aplastic anemia, but no other cytostatic drugs.…”

Avascular Necrosis of Bone: A Complication of Aggressive Therapy for Acute Lymphoblastic Leukemia

“…Avascular necrosis of bone (AVNB) is a recognized complication of cancer therapy which also occurs following trauma (1), sickle cell disease (2), Caisson disease (3), alcoholism (4) Gaucher's disease (5) and organ transplantation (6). The most frequent risk factor for AVNB is, however, steroid administration.…”

Hazards of steroid therapy in hepatic failure

“…Cirrhosis is known to be associated with aseptic necrosis (Jones, 1965;Jones & Engelman, 1967). The precise mechanism is still uncertain but fat emboli from the liver have been incriminated (Jones & Engelman, 1967). We suggest that in our patients the exogenous steroids were a contributing factor.…”