Osseointegration of zirconia and titanium implants in a rabbit tibiae model evaluated by microtomography, histomorphometry and fluorochrome labeling analyses

Martins, Ramiro C.; Cestari, Tânia Mary; Arantes, Ricardo Vinicius Nunes; Santos, Patrícia Bittencourt Dutra dos; Taga, Rumio; Carbonari, Marcelo José; Oliveira, Rodrigo Cardoso de

doi:10.1111/jre.12508

Cited by 13 publications

(17 citation statements)

References 51 publications

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“…The human osteoblast-like (MG-63) cells are commonly used osteoblastic models that are used to study bone cell viability, adhesion, and proliferation on the surfaces of load-bearing biomaterials [ 6 ]. Ti-6Al-4V and its compounds are gold standard materials for implants or abutments owing to their excellent mechanical strength, chemical stability, biocompatibility, and high osseointegration ability [ 6 , 12 ]. Martins et al found that the bone response to Y-TZP implants is comparable with that observed around Ti-6Al-4V implants [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ti-6Al-4V and its compounds are gold standard materials for implants or abutments owing to their excellent mechanical strength, chemical stability, biocompatibility, and high osseointegration ability [ 6 , 12 ]. Martins et al found that the bone response to Y-TZP implants is comparable with that observed around Ti-6Al-4V implants [ 12 ]. The present study did not conduct in vivo experimentation, but the analysis of the cell viability (MTT test) of the PEEK and MG-63 cells in this study ( Figure 7 ) suggested that PEEK yields equivalent cell viability responses to those of Ti-6Al-4V or Y-TZP ( p > 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in the past decade, the choice of materials for dental implants or abutment has gradually shifted to aesthetic materials. Evidence from several studies pointed out that compared with titanium alloys, the aesthetic zirconia-based ceramic materials demonstrated a low risk of inflammatory reactions and enhanced bone apposition; correspondingly, zirconia is viewed as a new dental implant or abutment material [ 10 , 11 , 12 ]. Nonetheless, the hardness characteristics will allow zirconia implants or abutments to directly transfer the stresses or impact forces (e.g., occlusal forces) to the surrounding bones via the implant–bone interface, and thus impose a heavy burden on the jawbone and induce other undesirable symptoms [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

et al. 2021

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Poly-ether-ether-ketone (PEEK) is an aesthetically pleasing natural material with good biocompatibility and shock absorption characteristics. The application of PEEK as a dental implant or abutment is expected to reduce the risk of failure and enhance aesthetics. Given that approximately one in 15 patients have allergic reactions to antibiotics, photodynamic therapy (PDT) has been gaining attention as an alternative treatment. Herein, the applicability of PEEK dental implants or abutments was investigated using material analyses, biofilm formation assay, and cell viability tests. The possible use of PDT for peri-implant mucositis was evaluated with the biofilm removal assay. The obtained data were analyzed based on the multivariate analysis of variance, paired t-tests, and the Pearson correlation coefficient (α = 0.05). The results revealed that PEEK was significantly less conducive to the formation of biofilms with S. mutans and A. actinomycetemcomitan (p < 0.001) but exhibited comparable MG-63 (human osteoblast-like) osteoblast cell viability (p > 0.05) to the other materials. PDT had similar antimicrobial efficacy and yielded similar biofilm removal effects to antibiotics. Altogether, these findings suggest that PEEK has attractive features and can serve as an alternative material for dental implants or abutments. In cases where peri-implant mucositis occurs, PDT can be used as an accessible therapeutic approach.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

et al. 2021

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“…In this area, 3- to 4-mm diameter implants can be used with lengths of up to 7 mm [ 306 ]. Rabbit tibia has been widely used to analyze the osseointegration of zirconia implants [ 307 ], titanium–zirconium implants [ 308 ], implants coated with calcium carbonate [ 309 ], and implants with surface modifications [ 306 , 310 , 311 ].Bilateral procedures are generally described including (i) two implants per animal with one implant in each tibia [ 311 ]; (ii) four implants per animal with two implants in each [ 312 ] or (iii) six implants per animal with three implants per tibia [ 313 , 314 ]. The metaphysis and diaphysis of the bone can be used.…”

Section: Appendix A1 Research In Non-human Primatesmentioning

confidence: 99%

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

et al. 2021

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Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be used for studies conducted under compromised oral conditions (biofilm). Regarding small animal models, research studies mostly use rodents, with interest in rabbit models declining. Mouse models remain a reference for genetic studies. On the other hand, over the last decade, scientific advances and government guidelines have led to the replacement, reduction, and refinement of the use of all animal models in dental implant research. In new development strategies, some in vivo experiments are being progressively replaced by in vitro or biomaterial approaches. In this review, we summarize the key information on the animal models currently available for dental implant research and highlight (i) the pros and cons of each type, (ii) new levels of decisional procedures regarding study objectives, and (iii) the outlook for animal research, discussing possible non-animal options.

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“…In contrast, implantable prostheses are still mostly made of titanium and its alloys, although novel and highly resistant ceramics, i.e., zirconia, could represent a viable alternative [ 19 , 20 ]. Titanium is a very biocompatible metal, which has been shown to represent an efficient material for orthopedic and dental implants [ 21 ].…”

Section: Biomaterials and Bone Regenerationmentioning

confidence: 99%

The Use of Pulsed Electromagnetic Fields to Promote Bone Responses to Biomaterials In Vitro and In Vivo

Galli

Pedrazzi

Mattioli‐Belmonte

et al. 2018

International Journal of Biomaterials

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Implantable biomaterials are extensively used to promote bone regeneration or support endosseous prosthesis in orthopedics and dentistry. Their use, however, would benefit from additional strategies to improve bone responses. Pulsed Electromagnetic Fields (PEMFs) have long been known to act on osteoblasts and bone, affecting their metabolism, in spite of our poor understanding of the underlying mechanisms. Hence, we have the hypothesis that PEMFs may also ameliorate cell responses to biomaterials, improving their growth, differentiation, and the expression of a mature phenotype and therefore increasing the tissue integration of the implanted devices and their clinical success. A broad range of settings used for PEMFs stimulation still represents a hurdle to better define treatment protocols and extensive research is needed to overcome this issue. The present review includes studies that investigated the effects of PEMFs on the response of bone cells to different classes of biomaterials and the reports that focused on in vivo investigations of biomaterials implanted in bone.

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Osseointegration of zirconia and titanium implants in a rabbit tibiae model evaluated by microtomography, histomorphometry and fluorochrome labeling analyses

Cited by 13 publications

References 51 publications

Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

The Use of Pulsed Electromagnetic Fields to Promote Bone Responses to Biomaterials In Vitro and In Vivo

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