Osseointegration of oxidized and turned implants in circumferential bone defects with and without adjunctive therapies: an experimental study on BMP-2 and autogenous bone graft in the dog mandible

Salata, Luiz Antônio; Burgos, Patricia Miranda; Rasmusson, Lars; Novaes, Arthur B.; Papalexiou, Vula; Dahlin, Christer; Sennerby, Lars

doi:10.1016/j.ijom.2006.07.009

Cited by 37 publications

(39 citation statements)

References 20 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results suggest that resonant frequency analysis lacked sufficient resolution to detect biomechanical changes due to osseointegration in the present study. While some studies using RFA have showed statistically significant increase in implant stability from placement to 4–6-week healing [12, 13], others have shown no significant differences [4]. However, it is known that ISQ values often do not correlate with histomorphometric analyses and bone osseointegration [22].…”

Section: Discussionmentioning

confidence: 99%

Anodisation Increases Integration of Unloaded Titanium Implants in Sheep Mandible

Duncan

Bae

Lee

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

Spark discharge anodic oxidation forms porous TiO2 films on titanium implant surfaces. This increases surface roughness and concentration of calcium and phosphate ions and may enhance early osseointegration. To test this, forty 3.75 mm × 13 mm titanium implants (Megagen, Korea) were placed into healed mandibular postextraction ridges of 10 sheep. There were 10 implants per group: RBM surface (control), RBM + anodised, RBM + anodised + fluoride, and titanium alloy + anodised surface. Resonant frequency analysis (RFA) was measured in implant stability quotient (ISQ) at surgery and at sacrifice after 1-month unloaded healing. Mean bone-implant contact (% BIC) was measured in undemineralised ground sections for the best three consecutive threads. One of 40 implants showed evidence of failure. RFA differed between groups at surgery but not after 1 month. RFA values increased nonsignificantly for all implants after 1 month, except for controls. There was a marked difference in BIC after 1-month healing, with higher values for alloy implants, followed by anodised + fluoride and anodised implants. Anodisation increased early osseointegration of rough-surfaced implants by 50–80%. RFA testing lacked sufficient resolution to detect this improvement. Whether this gain in early bone-implant contact is clinically significant is the subject of future experiments.

show abstract

Section: Discussionmentioning

confidence: 99%

Anodisation Increases Integration of Unloaded Titanium Implants in Sheep Mandible

Duncan

Bae

Lee

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The use of the space-making device alone resulted in no or only minor signs of bone formation after 6 months of healing, even in cases where the sinus membrane was intact. 9,11,12 On the other hand, when the implant was installed using the two-stage approach, the implant was found in contact with fibrous tissue. 9 Differently, the two-stage procedure resulted in very few bone-to-implant contacts and no bone formation on the surface of the membrane.…”

Section: Figurementioning

confidence: 99%

Histological Findings Following the Use of a Space‐Making Device for Bone Reformation and Implant Integration in the Maxillary Sinus of Primates

Cricchio

Palma

Faria

et al. 2009

Clin Implant Dent Rel Res

View full text Add to dashboard Cite

The use of a space-making device, with the design used in the present study, does not result in bone formation at the sinus floor. However, membrane elevation and simultaneous placement of the device and an implant does result in bone formation at the implant surface while sites with implants placed 6 months after membrane elevation show only small amounts of bone formation. It is suggested that lack of stabilization of the device and/or a too extensive elevation of the membrane may explain the results.

show abstract

“…All animals were kept in a single room and fed a dried diet and water ad libitum. The sample size chosen was based on our previous similar studies [8]. First 0.8 mL of 0.2% Acepran with the active ingredient of Acepromazine was injected intramuscularly.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model

Hussain

Moharamzadeh

Brook

et al. 2012

International Journal of Dentistry

View full text Add to dashboard Cite

The aim of this study was to assess the osteoconductive and osteogenic properties of processed bovine dentin using a robust rabbit calvarial defect model. In total, 16 New Zealand White rabbits were operated to create three circular defects in the calvaria. One defect was left unfilled, one filled with collected autogenous bone, and the third defect was filled with the dentin-based bone substitute. Following surgery and after a healing period of either 1 or 6 weeks, a CT scan was obtained. Following sacrificing, the tissues were processed for histological examination. The CT data showed the density in the area grafted with the dentin-based material was higher than the surrounding bone and the areas grafted with autologous bone after 1 week and 6 weeks of healing. The area left unfilled remained an empty defect after 1 week and 6 weeks. Histological examination of the defects filled with the dentin product after 6 weeks showed soft tissue encapsulation around the dentin particles. It can be concluded that the rabbit calvarial model used in this study is a robust model for the assessment of bone materials. Bovine dentin is a biostable material; however, it may not be suitable for repairing large 4-wall defects.

show abstract

Osseointegration of oxidized and turned implants in circumferential bone defects with and without adjunctive therapies: an experimental study on BMP-2 and autogenous bone graft in the dog mandible

Cited by 37 publications

References 20 publications

Anodisation Increases Integration of Unloaded Titanium Implants in Sheep Mandible

Anodisation Increases Integration of Unloaded Titanium Implants in Sheep Mandible

Histological Findings Following the Use of a Space‐Making Device for Bone Reformation and Implant Integration in the Maxillary Sinus of Primates

Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model

Contact Info

Product

Resources

About