Osseointegration of dental implants without primary stability: an experimental study in sheep

Shihab, Omed I.; Samad, Abduljaleel Azad; Ali, Hozak Zahir; Omer, Othman A.; Haider, Ahmed A.

doi:10.15218/zjms.2017.011

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Previous studies of dental implant designs and surfaces have used sheep [ 19 – 21 , 23 , 24 ], rabbit [ 7 , 25 , 26 ], and dog [ 27 – 29 ] models. The most commonly used sites in these animals are the mandible [ 27 , 28 ] and tibia [ 29 ] in dogs, the tibia [ 4 , 7 , 25 , 26 ] in rabbits, and the tibia [ 5 , 23 ], iliac crest [ 19 – 21 , 24 ], and mandible [ 30 ] in sheep. The iliac crest site offers advantages in bone characteristics, lower postoperative morbidity, and the number of implant tests that can be performed simultaneously.…”

Section: Discussionmentioning

confidence: 99%

In vivo osseointegration evaluation of implants coated with nanostructured hydroxyapatite in low density bone

et al. 2023

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Objective This in vivo study, aimed to biomechanically, histomorphometrically and histologically evaluate an implant surface coated with nanostructured hydroxyapatite using the wet chemical process (biomimetic deposition of calcium phosphate coating) when compared to a dual acid-etching surface. Material and methods Ten sheep (2–4 years old) received 20 implants, 10 with nanostructured hydroxyapatite coating (HAnano), and 10 with dual acid-etching surface (DAA). The surfaces were characterized with scanning electron microscopy and energy dispersive spectroscopy; insertion torque values and resonance frequency analysis were measured to evaluate the primary stability of the implants. Bone-implant contact (BIC) and bone area fraction occupancy (BAFo) were evaluated 14 and 28 days after implant installation. Results The HAnano and DAA groups showed no significant difference in insertion torque and resonance frequency analysis. The BIC and BAFo values increased significantly (p<0.05) over the experimental periods in both groups. This event was also observed in BIC value of HAnano group. The HAnano surface showed superior results compared to DAA after 28 days (BAFo, p = 0.007; BIC, p = 0.01). Conclusion The results suggest that the HAnano surface favors bone formation when compared to the DAA surface after 28 days in low-density bone in sheep.

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Section: Discussionmentioning

confidence: 99%

In vivo osseointegration evaluation of implants coated with nanostructured hydroxyapatite in low density bone

et al. 2023

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“… 43 Previous studies of dental-implant designs and surface have used sheep, 30 , 33–36 , 45 rabbits, 4 , 20 , 46 and dogs 47–49 as animal models. The most used sites in these animals are the jaw 47 , 48 or tibia 49 in dogs; the tibia 4 , 20 , 46 , 50 in rabbits; and the tibia, 34 , 35 iliac crest, 30 , 33 , 36 , 45 and mandible 51 in sheep. The iliac crest site offers the advantages of bone characteristics, the absence of postoperative morbidity, and the ability to conduct a high number of implants test simultaneously; however, although the iliac crest exhibits low bone density, the cortical is thicker relative to the thin cortical of the posterior region of the maxilla, which also shows low bone density.…”

Section: Discussionmentioning

confidence: 99%

<p>The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone</p>

Sartoretto

Calasans-Maia

Resende

et al. 2020

IJN

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Background and Objective The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep. Methods Ten female sheep (2–4 years) received 30 implants (n=10/group): HAnano ® coated (Epikut Plus ® , S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX ® , Straumann, Basel, Switzerland), and TiUnite (NobelActive ® , Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement. Results The surface morphology was considerably comparable between the implant groups’; however, the TiUnite ® group presented a remarkable different surface. The SLActive ® and TiUnite ® groups presented an insertion torque average of 74 (±8.9) N/cm that was similar to that of HAnano ® 72 (±8.3) N/cm (p >0.05). The resonance frequency evaluated with Osstell ® /SmartPeg ® or Penguin ® /MulTipeg ® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p<0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants. Conclusion HAnano ® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model.

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“…Experimental studies have also evaluated the different biological behaviour depending on the macro-surface topography, demonstrating increased attachment strength and higher removal torque in implants with moderately rough surfaces (Johansson, Sennerby, & Albrektsson, 1991;Pebe et al, 1997). Moreover, when these modified surface implants were placed without mechanical engagement, although in intimate contact with the host bone, osseointegration predictably occurred via contact osteogenesis in the absence of inflammation (Jung et al, 2012;Kim et al, 2014;Shihab, Samad, Ali, Omer, & Haider, 2017).…”

Section: Discussionmentioning

confidence: 99%

A retrospective case series evaluating the outcome of implants with low primary stability

Lee

Kook

Sanz‐Martín

et al. 2019

Clinical Oral Implants Res

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Objectives There is a need of more studies on whether low primary implant stability would negatively influence the success of implant therapy. Therefore, this retrospective study analyses outcomes of implants placed with low primary stability and factors that may be related to implant failures. Material and methods This retrospective study included 156 patients, restored with 169 implants that presented manual rotation within an observed follow‐up time of a minimum of 34 days and a maximum of 9.28 years. Descriptive statistics, survival analyses (life tables and Kaplan–Meier estimates) and radiographic assessment based on marginal bone level measurements were performed. This original study was adherent to STROBE guidelines. Results Seven implants failed in seven patients, rendering cumulative survival rates of 94.74% (95% CI: 89.11–97.50) and 94.33% (95% CI: 88.30–97.30) at implant and patient levels, respectively. Kaplan–Meier estimates showed implant loss was found only in advanced surgery group (7 implant loss in 82 implants) when compared with simple surgery group (no implant loss in 87 implants; p = 0.005). Conclusions Within the limitations of this retrospective study, implant placement with low primary stability might not negatively affect either the survival rates or marginal bone level changes of implants provided that a protected and unloaded healing is guaranteed.

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Osseointegration of dental implants without primary stability: an experimental study in sheep

Cited by 3 publications

References 12 publications

In vivo osseointegration evaluation of implants coated with nanostructured hydroxyapatite in low density bone

In vivo osseointegration evaluation of implants coated with nanostructured hydroxyapatite in low density bone

<p>The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone</p>

A retrospective case series evaluating the outcome of implants with low primary stability

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