Osseointegration of dental implants in rabbit bone with low mineral density

Mori, Hisatake; Manabe, Masato; Kurachi, Yoshihisa; Nagumo, Masao

doi:10.1016/s0278-2391(97)90124-5

Cited by 142 publications

(122 citation statements)

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“…Literature of clinical studies investigating the increased risk for implant failure in osteoporotic patients reveals contradictory outcomes [27][28][29]. The study of Friberg et al [30] reported an overall 97 % success rate of implants installed in maxilla and mandible of osteoporotic patients after a 3-year follow-up period, thereby suggesting that osteoporosis is not affecting implant success.…”

Section: Discussionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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Summary High-frequency loading via whole body vibration promotes bone formation and increases bone strength. Whether this translates to positive titanium implant osseointegration in osteoporotic bone was explored in this animal study. An anabolic effect of not only bisphosphonate treatment but also high-frequency loading on implant osseointegration in osteoporotic bone was observed. Introduction The present study investigated the impact of high-frequency (HF) loading, applied via whole body vibration (WBV), on titanium implant osseointegration in healthy versus ovariectomyinduced compromised versus pharmacologically treated compromised bone. Methods A custom-made Ti implant was inserted into the metaphyseal tibia of 59 rats and left to heal for either 4 or 14 days. Rats were divided into six groups according to their hormonal and mechanical status. WBV, consisting of 10 consecutive frequency steps at an acceleration of 0.3g, was applied daily for either 4 or 14 days. Tissue samples were processed for quantitative histology at the tibial cortical and medullar level. Data were analyzed by three-way ANOVA and by post hoc pairwise comparisons. Results The bone healing response at the interface and surrounding titanium implants was negatively influenced by osteoporotic bone conditions, mainly at the trabecular bone level. Furthermore, the administration of bisphosphonates for preventing the ovariectomy-induced impaired periimplant response was successful. Finally, the effect of HF WBV loading on the peri-implant bone healing was dependent on the bone condition and was anabolic solely in untreated osteoporotic trabecular bone when applied for an extended period of time. ConclusionsThe bone healing response to implant installation is compromised in osteoporotic bone conditions, in particular at the trabecular bone compartment. Meanwhile, not only pharmacological treatment but also mechanical loading via HF WBV can exert a positive effect on implant osseointegration in this specific bone micro-environment. The peri-implant cortical bone, however, seems to be less sensitive to HF WBV loading influences.

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Section: Discussionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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“…total hip replacement) are placed in persons over 65 years old and many of these patients are postmenopausal women with osteoporosis. Achieving a stable biological interface in the axial, appendicular and mandibular bone of the elderly, osteopenic postmenopausal patient in a shorter period of time is therefore of great interest (Eckhoff et al, 1995;Turner et al, 1996a,c;Mori et al, 1997;Fujimoto et al, 1998;Seebeck et al, 2000; Running title: Animal models -osteoporosis Fini et al, 2001). It is intuitive that an osteoconductive ceramic coating on hip implants in these osteoporotic patients may improve fixation.…”

Section: Appendicular Skeletonmentioning

confidence: 99%

Animal models of osteoporosis - necessity and limitations

2001

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There is a great need to further characterise the available animal models for postmenopausal osteoporosis, for the understanding of the pathogenesis of the disease, investigation of new therapies (e.g. selective estrogen receptor modulators (SERMs)) and evaluation of prosthetic devices in osteoporotic bone. Animal models that have been used in the past include non-human primates, dogs, cats, rodents, rabbits, guinea pigs and minipigs, all of which have advantages and disadvantages. Sheep are a promising model for various reasons: they are docile, easy to handle and house, relatively inexpensive, available in large numbers, spontaneously ovulate, and the sheep's bones are large enough to evaluate orthopaedic implants. Most animal models have used females and osteoporosis in the male has been largely ignored. Recently, interest in development of appropriate prosthetic devices which would stimulate osseointegration into osteoporotic, appendicular, axial and mandibular bone has intensified. Augmentation of osteopenic lumbar vertebrae with bioactive ceramics (vertebroplasty) is another area that will require testing in the appropriate animal model. Using experimental animal models for the study of these different facets of osteoporosis minimizes some of the difficulties associated with studying the disease in humans, namely time and behavioral variability among test subjects. New experimental drug therapies and orthopaedic implants can potentially be tested on large numbers of animals subjected to a level of experimental control impossible in human clinical research.

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“…The effect of a decrease in bone density on dentalimplant healing has been little investigated [2], and so far it is not known whether bone density and quality influence the favorable prognosis of dental implants. Jaffin and Berman [3] reported a higher failure rate for implants placed in bone with low bone mineral density (BMD) and an increase in the time of osseointegration, whereas Mori et al [4] observed inadequate bone formation adjacent to the implant. Von Wower et al [5] demonstrated that BMD is significantly lower in the oral cavity of patients with systemic osteoporosis than in normal subjects.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of axial and femoral bone mineral density and parameters of mandibular bone quality in patients receiving dental implants

et al. 2007

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Introduction: In view of the increase in the life expectancy of humans and in edentulism of the population above 50 years of age, in which the prevalence of osteoporosis is also higher, it is fundamental to better understand the effects of systemic bone mass loss on the healing process of dental implants and to determine the quality of the bone that surrounds them. The objective of the present study was to compare systemic osteoporosis (axial and femoral) and parameters of mandibular bone quality, and to evaluate osseointegration in postmenopausal women receiving dental implants. Methods: The sample consisted of 39 women aged 48-70 years, 19 with a densitometric diagnosis of osteoporosis in the lumbar spine and femoral neck and 20 controls with a normal densitometric diagnosis. Bone mineral density was measured in the patients and controls by dual-energy X-ray absorptiometry. Eighty-two osseointegrated dental implants were placed in the mandible, 39 of them in the osteoporosis group and 43 in the control group. Mandibular bone quality was evaluated by classifying mandibular inferior cortical and trabecular bone on panoramic radiographs and by histomorphometric analysis of a mandibular bone biopsy. Osseointegration was analyzed after 9 months. Results: No significant difference was observed between patients with osteoporosis and controls when comparing individuals with a normal cortex and those with a severely or moderately eroded cortex determined on panoramic radiographs, although patients with MEC/SEC had lower femoral neck BMD than those with NC (0.688 ± 0.17 vs. 0.814 ± 0.144 g/cm 2 , P<0.012). Histomorphometric analysis also revealed no difference in the parameters of bone formation or resorption between the two groups. Implant failure was observed in only one case. Conclusion: We conclude that there is an association between low femoral neck BMD and poor mandibular bone quality as assessed by panoramic radiography. The loss of one implant (1.2%) is compatible with the literature and cannot be attributed to systemic osteoporosis.

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Osseointegration of dental implants in rabbit bone with low mineral density

Cited by 142 publications

References 19 publications

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

Animal models of osteoporosis - necessity and limitations

Comparative study of axial and femoral bone mineral density and parameters of mandibular bone quality in patients receiving dental implants

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