Osseointegration of dental implants in 3D-printed synthetic onlay grafts customized according to bone metabolic activity in recipient site

Tamimi, Faleh; Torres, Juan Ramón Fernández; Al‐Abedalla, Khadijeh; López-Cabarcos, Enrique; Alkhraisat, Mohammad Hamdan; Bassett, D. C.; Gbureck, Uwe; Barralet, Jake E.

doi:10.1016/j.biomaterials.2014.03.050

Cited by 94 publications

(90 citation statements)

References 37 publications

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“…Monetite bioceramic materials have been tested as onlay blocks (3D printed) for vertical bone augmentation and in the form of granules as bone defect fillers [2,273,307,317]. It has been shown that monetite blocks can be used as synthetic onlay bone grafts and can achieve adequate vertical augmentation for dental implant placement [97].…”

Section: Natural Transplants and Synthetic Bone Replacement Graft mentioning

confidence: 99%

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Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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Alveolar bone augmentation in vertical dimension remains the holy grail of periodontal tissue engineering. Successful dental implant placement for restoration of edentulous sites depends on the quality and quantity of alveolar bone available in all spatial dimensions. There are several surgical techniques used alone or in combination with natural or synthetic graft materials to achieve vertical alveolar bone augmentation. While continuously improving surgical techniques combined with the use of auto- or allografts provide the most predictable clinical outcomes, their success often depends on the status of recipient tissues. The morbidity associated with donor sites for auto-grafts makes these techniques less appealing to both patients and clinicians. New developments in material sciences offer a range of synthetic replacements for natural grafts to address the shortcoming of a second surgical site and relatively high resorption rates. This narrative review focuses on existing techniques, natural tissues and synthetic biomaterials commonly used to achieve vertical bone height gain in order to successfully restore edentulous ridges with implant-supported prostheses.

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Section: Natural Transplants and Synthetic Bone Replacement Graft mentioning

confidence: 99%

“…The long-term success of dental implants is highly dependent upon the degree of osseointegration in sufficient and healthy bone [1,2,3,4,5,6]. Bone volume is often reduced due to extended time after tooth loss before implant placement, or due to periodontitis or trauma [1,7,8].…”

Section: Introductionmentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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“…Furthermore, with the application of the AM technology, the geometrical structure of the scaffold can be precisely controlled and targeted mechanical and biological properties can be achieved through functionally graded architectures. Scaffolds with pore sizes ranging from 300 to 400 μm were found to cause a remarkable improvement in bone tissue recovering [40]. The promoting effect on bone regeneration increased with increasing sizes of pores that were in the near-bone area of the scaffold.…”

Section: Requirements Of Bte Scaffoldsmentioning

confidence: 99%

Additively Manufactured Scaffolds for Bone Tissue Engineering and the Prediction of their Mechanical Behavior: A Review

2017

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Additive manufacturing (AM), nowadays commonly known as 3D printing, is a revolutionary materials processing technology, particularly suitable for the production of low-volume parts with high shape complexities and often with multiple functions. As such, it holds great promise for the fabrication of patient-specific implants. In recent years, remarkable progress has been made in implementing AM in the bio-fabrication field. This paper presents an overview on the state-of-the-art AM technology for bone tissue engineering (BTE) scaffolds, with a particular focus on the AM scaffolds made of metallic biomaterials. It starts with a brief description of architecture design strategies to meet the biological and mechanical property requirements of scaffolds. Then, it summarizes the working principles, advantages and limitations of each of AM methods suitable for creating porous structures and manufacturing scaffolds from powdered materials. It elaborates on the finite-element (FE) analysis applied to predict the mechanical behavior of AM scaffolds, as well as the effect of the architectural design of porous structure on its mechanical properties. The review ends up with the authors’ view on the current challenges and further research directions.

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“…This anhydrous form of brushite, known as monetite or anhydrous dicalcium phosphate (DCPA), does not transform to insoluble HA post implantation and undergoes greater resorption than brushite . Monetite has been investigated previously to try to regenerate bone in animal and human studies, and demonstrated a greater volume of bone tissue formation than HA biomaterials …”

Section: Introductionmentioning

confidence: 99%

“…9,[11][12][13][14] Brushite, also known as dicalcium phosphate dihydrate (DCPD), can be synthesized as a hydraulic cement with uses in several applications. 15 Brushites have been tested with success for vertical bone augmentation, 13,[16][17][18] but they tend to re-precipitate as insoluble HA after implantation, which limits resorption and ultimately graft replacement by bone tissue. 19 Heating and dehydrating brushite cements above 60 C, 20 result in monetite biomaterials that are chemically very similar to brushite but differ in physical properties.…”

Section: Introductionmentioning

confidence: 99%

Differential response of human blood leukocytes to brushite, monetite, and calcium polyphosphate biomaterials

et al. 2019

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Calcium phosphate‐based biomaterials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. The injury induced by surgical implantation of bone replacement graft materials initiates a cascade of host responses, starting with blood–biomaterial contact, protein adsorption on the material surface, blood coagulation, and leukocyte responses. During the initial acute inflammatory response, polymorphonuclear neutrophils (PMNs) and monocytes, abundant circulating leukocytes of the myeloid lineage, are recruited to the site of inflammation. In addition to responding to pathogenic challenges, these cells respond to particulate substances within the body including crystals of monosodium urate (MSU). Host responses toward grafts impact short‐ and long‐term success in tissue engineering and regenerative applications. Although multinucleated osteoclasts, formed by monocyte/macrophage fusion, are generally thought to be responsible for resorption of implant biomaterials, the ability of different biomaterials to trigger PMNs, which are invariably present at the early stages after implant surgery, and are abundant in the oral cavity, has never been tested. In this article, we present analysis of the response of human blood‐derived PMNs and monocytes toward brushite, monetite, and calcium polyphosphate (CPP) biomaterial substrates and compare this to the response to MSU crystals, the latter serving as a positive control. Employing multicolor flow cytometry to look at PMN and monocyte cell surface markers of activation to gauge the response to different biomaterials, we found that both types of myeloid cells are highly activated after exposure to brushite, monetite, and MSU but not CPP. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:253–262, 2020.

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Osseointegration of dental implants in 3D-printed synthetic onlay grafts customized according to bone metabolic activity in recipient site

Cited by 94 publications

References 37 publications

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Additively Manufactured Scaffolds for Bone Tissue Engineering and the Prediction of their Mechanical Behavior: A Review

Differential response of human blood leukocytes to brushite, monetite, and calcium polyphosphate biomaterials

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