Osseointegration of dental implants in ectopic engineered bone in three different scaffold materials

Naujokat, Hendrik; Acil, Y.; Harder, Sönke; Lipp, Maximilian; Böhrnsen, Florian; Wiltfang, Joerg

doi:10.1016/j.ijom.2019.04.005

Cited by 13 publications

(7 citation statements)

References 28 publications

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“…The chemical composition of BCP mimics the inorganic part of the natural bone matrix. ß-TCP degrades faster and has a different resorption pattern than HA, since HA is rigid, brittle, and has limited resorption after application (56,68). For effective graft remodeling, there should be an appropriate balance between the resorption rate of the graft materials and the growth of new bone formation.…”

Section: Discussionmentioning

confidence: 99%

Regenerating Craniofacial Dental Defects With Calcium Phosphate Cement Scaffolds: Current Status and Innovative Scope Review

et al. 2021

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The management and treatment of dental and craniofacial injuries have continued to evolve throughout the last several decades. Limitations with autograft, allograft, and synthetics created the need for more advanced approaches in tissue engineering. Calcium phosphate cements (CPC) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. This review focuses on the up-to-date performance of calcium phosphate cement (CPC) scaffolds and upcoming promising dental and craniofacial bone regeneration strategies. First, we summarized the barriers encountered in CPC scaffold development. Second, we compiled the most up to date in vitro and in vivo literature. Then, we conducted a systematic search of scientific articles in MEDLINE and EMBASE to screen the related studies. Lastly, we revealed the current developments to effectively design CPC scaffolds and track the enhanced viability and therapeutic efficacy to overcome the current limitations and upcoming perspectives. Finally, we presented a timely and opportune review article focusing on the significant potential of CPC scaffolds for dental and craniofacial bone regeneration, which will be discussed thoroughly. CPC offers multiple capabilities that may be considered toward the oral defects, expecting a future outlook in nanotechnology design and performance.

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Section: Discussionmentioning

confidence: 99%

Regenerating Craniofacial Dental Defects With Calcium Phosphate Cement Scaffolds: Current Status and Innovative Scope Review

et al. 2021

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“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate craniofacial tissue engineering 49‐72,74‐77,79,81‐84,145‐197 …”

Section: Discussionmentioning

confidence: 99%

“…By using an in vivo autologous tissue construct, biocompatibility is promoted and the risk of dehiscence, such as has been seen with titanium mesh, can be mitigated 81 . It has also since been shown that dental implants are able to be osseointegrated into de novo tissue engineered bone in an animal model that utilized an in vivo bioreactor 84 …”

Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.

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“…Porosity allows cell migration through the canaliculi; when these are very small, vascular flow is diminished but when their size is greatly increased, the mechanical strength of the material diminishes (Alister et al, 2019). Naujokat et al (2020) studied ectopic bone formation in 3 groups of muscle tissue, using one cube of bovine HA, one biphase cube of HA and tricalcium phosphate, and one cube based on printed titanium. Perforations were created in the cubes in order to install a collagen membrane with cells from the iliac crest and rhBMP-2.…”

Section: Discussionmentioning

confidence: 99%

Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2

et al. 2020

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Bone morphogenetic protein (rhBMP-2) is a powerful osteo-inductive growth factor widely used in bone reconstruction and both the vehicle used to administer it and the scaffold substrate could determine its success in clinical situations. The aim was to analyse the clinical behaviour of dental implants placed in single alveolar ridges with a horizontal deficiency in the maxillary anterior region that were reconstructed horizontally with rhBMP-2 and porous hydroxyapatite (HA). Inclusion criteria were both males and females, between the ages of 18 and 29 with single tooth loss of one upper incisor. Cone Beam Computed Tomography (CBCT) was used to take measurements prior to bone augmentation and again prior to the implant insertion. Surgery was carried out under local anaesthetic. In the primary procedure, bone substitute was introduced using porous HA and rhBMP-2; after 4 to 5 months, dental implant surgery was carried out and the implant placed; after 3 months of consolidation the provisional prosthesis was placed and then a definitive restoration was placed. Variables were analysed using the t-test with a p-value of < 0.05 in order to assess statistical significance. Thirteen subjects were included (6 females and 7 males). Bone augmentation resulted in a bone gain of 4.15mm (p=0.023), which was shown to be statistically significant. All of the grafts placed were successful and 13 implants were placed, using torques between 30 and 70N, without complications. For the final prostheses, 1 1 were screw retained and 2 were cemented in place. The horizontal bone augmentation using HA and rhBMP-2 is an efficient technique for single bone defects in the anterior maxillary area; clinical trials on a larger scale are needed to confirm these results.

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Osseointegration of dental implants in ectopic engineered bone in three different scaffold materials

Cited by 13 publications

References 28 publications

Regenerating Craniofacial Dental Defects With Calcium Phosphate Cement Scaffolds: Current Status and Innovative Scope Review

Regenerating Craniofacial Dental Defects With Calcium Phosphate Cement Scaffolds: Current Status and Innovative Scope Review

Tissue engineering applications in otolaryngology—The state of translation

Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2

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