Osseointegration: Long‐Term Prevention of Bacterial Infection and Enhanced Osteoinductivity of a Hybrid Coating with Selective Silver Toxicity (Adv. Healthcare Mater. 5/2019)

Xie, Kai; Zhou, Ziao; Yu, Guoqing; Wang, Lei; Li, Guoyuan; Liu, Xiangmei; Li, Jun; Jiang, Wenbo; Wu, Shuilin; Hao, Yongqiang

doi:10.1002/adhm.201970020

Cited by 8 publications

(10 citation statements)

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“…In previous studies, it has been shown that silver ions can bind to proteins or DNA of mammalian cells and produce reactive oxygen species in the microenvironment, which leads to cell death or apoptosis (Hsin et al, 2008). Also, the biological toxicity of silver ions is dose dependent, the design strategy to control their cellular and tissue toxicity may be to enable the silver-containing coating on the implant surface to provide controllable release of silver ions (Xie et al, 2019). In our previous study, we showed that nanoscale TiN/Ag multilayers with a smaller modulation period had excellent mechanical properties and cellular compatibility (Sun et al, 2016a).…”

Section: Discussionmentioning

confidence: 99%

Study on the osteogenesis of rat mesenchymal stem cells and the long‐term antibacterial activity of Staphylococcus epidermidis on the surface of silver‐rich TiN/Ag modified titanium alloy

et al. 2020

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The main causes of failure of orthopedic implants are infection and poor bone ingrowth. Surface modification of the implants to allow for long‐term antibacterial and osteogenic functions is an effective solution to prevent failure of the implants. We developed silver‐rich TiN/Ag nano‐multilayers on the surface of titanium alloy with different doses of Ag+. The antibacterial stability and osteogenesis of the silver‐rich surface were determined by evaluating the adhesion and proliferation of Staphylococcus epidermidis, and the adhesion, proliferation, alkaline phosphatase activity, extracellular matrix mineralization, and the expression level of genes involved in osteogenic differentiation of rat bone mesenchymal stem cells (BMSCs). The results demonstrated that the antibacterial rates (Ra) of 5 × 1016‐Ag, 1 × 1017‐Ag, 5 × 1017‐Ag, and 1 × 1018‐Ag were respectively 46.21%, 85.66%, 94.99%, 98.48%, and 99.99%. After subcutaneous implantation in rats or immersion in phosphate buffered saline for up to 12 weeks, the silver‐rich surface of the titanium alloy showed long‐term stable inhibition of Staphylococcus epidermidis. Furthermore, in vitro and in vivo studies indicated that the Ag‐implanted titanium did not show apparent cytotoxicity and that lower Ag+ implanted groups (5 × 1016‐Ag, 1 × 1017‐Ag) had better viability and biological safety when compared with higher Ag+ implanted groups. In addition, when compared with the Ti6Al4V‐group, all Ag‐implanted groups exhibited enhanced osteogenic indicators in rat BMSCs. Regarding osteogenic indicators, the surfaces of the 5 × 1017‐Ag group had better osteogenic effects than those of other groups. Therefore, the proper dose of Ag+ implanted TiN/Ag nano‐multilayers may be one of the options for the hard tissue replacement materials with antibacterial activity and osteogenic functions.

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Section: Discussionmentioning

confidence: 99%

Study on the osteogenesis of rat mesenchymal stem cells and the long‐term antibacterial activity of Staphylococcus epidermidis on the surface of silver‐rich TiN/Ag modified titanium alloy

et al. 2020

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“…◯ ⊙ [68,127,210] ◯ Nb 1)Enhances the activity and mineralization of human osteoblasts and has little cytotoxicity when supplemented in vitro.…”

Section: ◯ ◯ ◯mentioning

confidence: 99%

Current Advances in the Roles of Doped Bioactive Metal in Biodegradable Polymer Composite Scaffolds for Bone Repair: A Mini Review

Liu

et al. 2022

Adv Eng Mater

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The election of bone tissue engineering scaffolds material is mainly based on the bionics of natural bones. Although the content of trace elements in bone is low, the lack of them affects the growth and metabolism of bones, thus increasing the risk of orthopedic diseases caused by the deterioration of bone quality. Therefore, inspired by trace elements in natural bone, biodegradable polymer composite scaffolds doped with bioactive metals such as Mg, Zn, Sr, Fe, Cu, Mn, Co, Li, Ag, Nb, and V have attracted more attention. Herein, the role of bioactive metals doping in biodegradable polymer matrix is mainly reviewed, including improving hydrophilicity, preventing aseptic inflammation caused by acidic degradation products, imparting antibacterial activity, improving mechanical properties, and promoting vascularization of polymer scaffolds. Then, the reasons and solutions for interfacial bonding and cytotoxicity caused by doping bioactive metals are focused on.

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“…[ 50,165–168 ] The dual chelating effect of PDA and chitosan has been demonstrated to significantly reduce Ag ion release with excellent antibacterial effect toward S. aureus , S. epidermidis , and E. coli ( Figure ). [ 171 ] The pH level at the peri‐implant during bacterial infection is reduced to as low as 5.5. A pH‐sensitive coating consisting of AgNPs and acetal linker has been fabricated and the Ag ion is released at low pH when bacterial infection occurs.…”

Section: Ion‐incorporated Coating On Ti For Enhanced Osteogenic and Amentioning

confidence: 99%

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Zhao

et al. 2020

Adv Healthcare Materials

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Bone fracture is prevalent among athletes and senior citizens and may require surgical insertion of bone implants. Titanium (Ti) and its alloys are widely used in orthopedics due to its high corrosion resistance, good biocompatibility, and modulus compatible with natural bone tissues. However, bone repair and regrowth are impeded by the insufficient intrinsic osteogenetic capability of Ti and Ti alloys and potential bacterial infection. The physicochemical properties of the materials and nano/microstructures on the implant surface are crucial for clinical success and loading with biofunctional elements such as Sr, Zn, Cu, Si, and Ag into nano/microstructured TiO 2 coating has been demonstrated to enhance bone repair/regeneration and bacterial resistance of Ti implants. In this review, recent advances in biofunctional element-incorporated nano/microstructured coatings on Ti and Ti alloy implants are described and the prospects and limitations are discussed.

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Osseointegration: Long‐Term Prevention of Bacterial Infection and Enhanced Osteoinductivity of a Hybrid Coating with Selective Silver Toxicity (Adv. Healthcare Mater. 5/2019)

Cited by 8 publications

References 0 publications

Study on the osteogenesis of rat mesenchymal stem cells and the long‐term antibacterial activity of Staphylococcus epidermidis on the surface of silver‐rich TiN/Ag modified titanium alloy

Study on the osteogenesis of rat mesenchymal stem cells and the long‐term antibacterial activity of Staphylococcus epidermidis on the surface of silver‐rich TiN/Ag modified titanium alloy

Current Advances in the Roles of Doped Bioactive Metal in Biodegradable Polymer Composite Scaffolds for Bone Repair: A Mini Review

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

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