Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon

Veronesi, Francesca; Giavaresi, Gianluca; Fini, Milena; Longo, Giovanni; Ioannidu, Caterina Alexandra; d’Abusco, Anna Scotto; Superti, Fabiana; Panzini, Gianluca; Misiano, Carlo; Palattella, A; Selleri, Paolo; Girolamo, Nicola Di; Garbarino, Viola; Politi, Laura; Scandurra, Roberto

doi:10.1016/j.msec.2016.08.076

Cited by 41 publications

(26 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cell cultures on a treated-polystyrene surface can lead to loss of differentiated status and/or cell functions, those on coated surfaces, as with poly-d-lysine, are time-consuming and expensive, and the biological coating with ECM components could provide a microenvironment for the cell growth that is different from the in vivo conditions, leading to modifications of the cellular behavior; [3][4][5]. In the last years, we studied nanostructured TiC material, and considering all its features [24,25], we decided to evaluate the 2D cell culture on this surface in comparison with cell cultures on treated-polystyrene and poly-d-Lysine-coated glass. The titanium carbide layer was produced by IPPA deposition [27][28][29][30] directly on glass slides, obtaining surfaces with 25% light transmittance ability.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, in our laboratory, nanostructured titanium surfaces have been analyzed, with the aim to find a surface with the best osseointegration features [24,25]. Titanium is used for most types of implants; moreover, modified titanium surfaces are more suitable for osseointegration, due to the increased wettability or to their microstructural features, such as the surface micro-and nano-roughness, which is very beneficial to cell growth and differentiation [26].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanostructured TiC Layer is Highly Suitable Surface for Adhesion, Proliferation and Spreading of Cells

et al. 2020

Self Cite

View full text Add to dashboard Cite

Cell culture is usually performed in 2D polymer surfaces; however, several studies are conducted with the aim to screen functional coating molecules to find substrates more suitable for cell adhesion and proliferation. The aim of this manuscript is to compare the cell adhesion and cytoskeleton organization of different cell types on different surfaces. Human primary fibroblasts, chondrocytes and osteoblasts isolated from patients undergoing surgery were seeded on polystyrene, poly-d-lysine-coated glass and titanium carbide slides and left to grow for several days. Then their cytoskeleton was analyzed, both by staining cells with phalloidin, which highlights actin fibers, and using Atomic Force Microscopy. We also monitored the production of Fibroblast Growth Factor-2, Bone Morphogenetic Protein-2 and Osteocalcin, using ELISA, and we highlighted production of Collagen type I in fibroblasts and osteoblasts and Collagen type II in chondrocytes by immunofluorescences. Fibroblasts, chondrocytes and osteoblasts showed both an improved proliferative activity and a good adhesion ability when cultured on titanium carbide slides, compared to polystyrene and poly-d-lysine-coated glass. In conclusion, we propose titanium carbide as a suitable surface to cultivate cells such as fibroblasts, chondrocytes and osteoblasts, allowing the preservation of their differentiated state and good adhesion properties.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanostructured TiC Layer is Highly Suitable Surface for Adhesion, Proliferation and Spreading of Cells

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is mainly resulted from the stronger affinity of the Ca 2+ ions to the TiN x O y present on the surface of Ti 2 AlN compared to the other oxidized forms tested. In another study performed by Veronesi et al, TiC‐coated implants were placed within rabbit femurs to improve the formation of bone around the implant as compared to the bare Ti implant. Interestingly, histological studies could not find any fibrous tissue, sign of necrosis, inflammatory reaction, osteolysis, or tissue degeneration for any of Ti and TiC implants.…”

Section: Biomedical Applications Of Mxenesmentioning

confidence: 99%

“…In addition, owning to superior crystal structures, different chemical compositions, rich surface chemistries, high metallic conductivities, excellent thermal/mechanical properties, unique morphology, and hydrophilic surface properties, MXenes have been exploited as promising candidates in transistors, energy storage devices,[7c] electrocatalysts, water desalination, electromagnetic interference shielding, electrochemical supercapacitors,[10b,13] Li‐ion batteries,[10b,14] conducting thin films, and many other applications. [7b,c] Moreover, with ever‐increasing attention to MXenes, these burgeoning 2D materials have successfully been applied in biomedical applications,[7b] such as photothermal therapy (PTT) in near‐infrared‐I (NIR‐I; 750–1000 nm) and NIR‐II biowindows (1000–1350 nm), diagnostic imaging,[16b,e,17] antimicrobial formulations, biosensing, drug delivery, and even tissue engineering . Thanks to abundant oxygen‐containing groups within the structure of MXenes, they possess high degree of functionalization capability, allowing the surface engineering of MXene nanosheets for desirable performance in biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Promoting Role of MXene Nanosheets in Biomedical Sciences: Therapeutic and Biosensing Innovations

Soleymaniha

Shahbazi

Rafieerad

et al. 2018

Adv Healthcare Materials

273

186

View full text Add to dashboard Cite

MXene nanosheets have emerged as biocompatible transition metal structures, which illustrate desirable performance for various applications due to their unique structural, physicochemical, and compositional features. MXenes are currently expanding their usage territory from mechanical, optical, chemical, and electronic fields toward biomedical areas. This is mainly originated from their large surface area and strong absorbance in near‐infrared region, which in combination with their facile surface functionalization with various polymers or nanoparticles, make them promising nanoplatforms for drug delivery, cancer therapy, precise biosensing and bioimaging. The facile surface modification of the MXenes can mediate the better in vivo performance of them through reduced toxicity, enhanced colloidal stability, and extended circulation within the body. Herein, the synthesis and state‐of‐the‐art progresses of MXene nanosheets designed for biomedical applications, including structural‐ and dose‐dependent antimicrobial activity, photothermal therapy, drug delivery, and implants are emphasized. Furthermore, biosensing applications are highlighted and a comprehensive discussion on photoacoustic imaging, magnetic resonance imaging, computed tomography imaging, and optical imaging of MXenes is presented. The challenges and future opportunities of applying MXene nanomaterials in the area of biomedicine are also discussed.

show abstract

“…Buharlaştırma [126], [127] İyon kaplama [128] Sıçratma (Sputtering) [129]- [132] Yüzeyde ∼1 μm kalınlığında TiN, TiC, TiCN, elmas ve elmas benzeri karbon ince film oluşturularak aşınma direnci, korozyon direnci ve biyouyumluluk iyileştirilir.…”

Section: Fiziksel Buhar Biriktirme (Pvd) Yöntemleriunclassified

Biomaterials Used in Orthopedic Implants

Güner¹,

Meran²

2020

Pamukkale J Eng Sci

View full text Add to dashboard Cite

Ortopedide biyomalzemeler, travma sonucu kırılan kemiklerin iyileşmesi için sabitleme ya da osteoporoz gibi bir hastalık tarafından hasar gören eklem ya da kemiklerin yerini alması amacıyla kullanılır. Bu malzemelerin çoğunluğunu metaller oluşturmaktadır. Metal olmayan malzemeler ise seramikler, polimerler ve kompozitler olarak üçe ayrılabilir. Bu çalışmada ortopedik implantların üretiminde kullanılan biyomalzemelerin çeşitleri, temel özellikleri, avantaj ve dezavantajları, kullanım alanları ve malzeme seçimine bağlı olarak oluşabilecek sorunlar özetlenmiştir.Orthopedic biomaterials are used in replacement of joints or bones that are damaged by a disease such as osteoporosis or fixation of broken bones. Majority of these materials are metals. Non-metallic materials can be separated into three groups as ceramics, polymers and composites. In this study, the types, fundamental properties, advantages and disadvantages of biomaterials used in the production of orthopedic implants are summarized.

show abstract

Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon

Cited by 41 publications

References 28 publications

Nanostructured TiC Layer is Highly Suitable Surface for Adhesion, Proliferation and Spreading of Cells

Nanostructured TiC Layer is Highly Suitable Surface for Adhesion, Proliferation and Spreading of Cells

Promoting Role of MXene Nanosheets in Biomedical Sciences: Therapeutic and Biosensing Innovations

Biomaterials Used in Orthopedic Implants

Contact Info

Product

Resources

About