Osseointegration improves bone–implant interface of pedicle screws in the growing spine: a biomechanical and histological study using an in vivo immature porcine model

Shiba, Kanako; Taneichi, Hiroshi; Namikawa, Takashi; Inami, Satoshi; Takeuchi, Daisaku; Nohara, Yutaka

doi:10.1007/s00586-017-5062-2

Cited by 10 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If the optimal pedicle screw could act as a fusion material with long-lasting bone integration, it could potentially avoid the preparation of additional fusion areas and surgical interventions, such as posterolateral fusion or interbody fusion [ 43 ]. Nonetheless, excellent mechanical fixation and stabilization of pedicle screws require strong bone–implant interface bonding and direct biological anchorage to the surrounding bone tissue [ 44 ]. Notably, the first four months after implantation are crucial for evaluating the bone ingrowth and bone remodeling process around the implants after osseointegration.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

Lam

Trinh

Huang

et al. 2020

IJMS

View full text Add to dashboard Cite

In this study, we optimized the geometry and composition of additive-manufactured pedicle screws. Metal powders of titanium-aluminum-vanadium (Ti-6Al-4V) were mixed with reactive glass-ceramic biomaterials of bioactive glass (BG) powders. To optimize the geometry of pedicle screws, we applied a novel numerical approach to proposing the optimal shape of the healing chamber to promote biological healing. We examined the geometry and composition effects of pedicle screw implants on the interfacial autologous bone attachment and bone graft incorporation through in vivo studies. The addition of an optimal amount of BG to Ti-6Al-4V leads to a lower elastic modulus of the ceramic-metal composite material, effectively reducing the stress-shielding effects. Pedicle screw implants with optimal shape design and made of the composite material of Ti-6Al-4V doped with BG fabricated through additive manufacturing exhibit greater osseointegration and a more rapid bone volume fraction during the fracture healing process 120 days after implantation, per in vivo studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

Lam

Trinh

Huang

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…4). 21 For measurement of the BV/TV ratios, the image-processing software ImageJ (National Institutes of Health) was used, and for measurement of the BS/IS ratios, the image-analysis software WinROOF (Mitani Co.) was used.…”

Section: Histological Analysismentioning

confidence: 99%

Pedicle screws with a thin hydroxyapatite coating for improving fixation at the bone-implant interface in the osteoporotic spine: experimental study in a porcine model

Ohe¹,

Moridaira²,

Inami³

et al. 2018

Journal of Neurosurgery: Spine

Self Cite

View full text Add to dashboard Cite

OBJECTIVEInstrumentation failure caused by the loosening of pedicle screws (PSs) in patients with osteoporosis is a serious problem after spinal surgery. The addition of a thin hydroxyapatite (HA) surface coating applied by using a sputtering process was reported recently to be a promising method for providing bone conduction around an implant without a significant risk of coating-layer breakage. In this study, the authors evaluated the biomechanical and histological features of the bone-implant interface (BII) of PSs with a thin HA coating in an in vivo porcine osteoporotic spine model.METHODSThree types of PSs (untreated/standard [STPS], sandblasted [BLPS], and HA-coated [HAPS] PSs) were implanted into the thoracic and lumbar spine (T9–L6) of 8 mature Clawn miniature pigs (6 ovariectomized [osteoporosis group] and 2 sham-operated [control group] pigs). The spines were harvested from the osteoporosis group at 0, 2, 4, 8, 12, or 24 weeks after PS placement and from the control group at 0 or 24 weeks. Their bone mineral density (BMD) was measured by peripheral quantitative CT. Histological evaluation of the BIIs was conducted by performing bone volume/tissue volume and bone surface/implant surface measurements. The strength of the BII was evaluated with extraction torque testing.RESULTSThe BMD decreased significantly in the osteoporosis group (p < 0.01). HAPSs exhibited the greatest mean extraction peak torque at 8 weeks, and HAPSs and BLPSs exhibited significantly greater mean torque than the STPSs at 12 weeks (p < 0.05). The bone surface/implant surface ratio was significantly higher for HAPSs than for STPSs after 2 weeks (p < 0.05), and bonding between bone and the implant surface was maintained until 24 weeks with no detachment of the coating layer. In contrast, the bone volume/tissue volume ratio was significantly higher for HAPSs than for BLPSs or STPSs only at 4 weeks.CONCLUSIONSUsing PSs with a thin HA coating applied using a sputtering process strengthens bonding at the BII, which might improve early implant fixation after spinal surgery for osteoporosis. However, the absence of increased bone mass around the screw remains a concern; prescribing osteoporosis treatment to improve bone quality might be necessary to prevent fractures around the screws.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Development of a synthetic paediatric spine is essential to investigate the mechanical behaviour of paediatric cases such as scoliosis. The common surgical procedure among paediatric cases is early onset scoliosis surgical treatment, and studies on the effect and accuracy of various paediatric spinal instrumentations of scoliosis normally were conducted only using FE studies, animal spines, or postoperative studies that required years of observation [ 11 , 16 , 17 ]. Therefore, it will be beneficial to have a working synthetic paediatric spine that can be used in spinal instrumentations of biomechanical investigations or preplanning of complicated surgical treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Paediatric spine is not miniature of adult spine; therefore, it cannot be treated as such. A few studies on paediatric biomechanical investigation still used human adult and immature porcine spine as their specimens due to the limitations of paediatric specimens [11][12][13] The main challenge in developing the paediatric biomechanical analyses was limited information of paediatric experimental data to enable a direct comparison with the finite element model. Recently, a few studies were reported on the use of paediatric human cadavers to investigate the paediatric biomechanical response [3,14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Experimental Analysis of Fabricated Synthetic Midthoracic Paediatric Spine as Compared to the Porcine Spine Based on Range of Motion (ROM)

Muhayudin

Basaruddin

Daud

et al. 2021

Applied Bionics and Biomechanics

View full text Add to dashboard Cite

The present study is aimed at investigating the mechanical behaviour of fabricated synthetic midthoracic paediatric spine based on range of motion (ROM) as compared to porcine spine as the biological specimen. The main interest was to ensure that the fabricated synthetic model could mimic the biological specimen behaviour. The synthetic paediatric spine was designed as a 200% scaled-up model to fit into the Bionix Servohydraulic spine simulator. Biomechanical tests were conducted to measure the ROM and nonlinearity of sigmoidal curves at six degrees of freedom (DOF) with moments at ±4 Nm before the specimens failed. Results were compared with the porcine spine (biological specimen). The differences found between the lateral bending and axial rotation of synthetic paediatric spine as compared to the porcine spine were 18% and 3%, respectively, but was still within the range. Flexion extension of the synthetic spine is a bit stiff in comparison of porcine spine with 45% different. The ROM curves of the synthetic paediatric spine exhibited nonlinearities for all motions as the measurements of neutral zone (NZ) and elastic zone (EZ) stiffness were below “1.” Therefore, it showed that the proposed synthetic paediatric spine behaved similarly to the biological specimen, particularly on ROM.

show abstract

Osseointegration improves bone–implant interface of pedicle screws in the growing spine: a biomechanical and histological study using an in vivo immature porcine model

Cited by 10 publications

References 22 publications

Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

Pedicle screws with a thin hydroxyapatite coating for improving fixation at the bone-implant interface in the osteoporotic spine: experimental study in a porcine model

Experimental Analysis of Fabricated Synthetic Midthoracic Paediatric Spine as Compared to the Porcine Spine Based on Range of Motion (ROM)

Contact Info

Product

Resources

About