Osseointegration evaluation of ZrTi alloys with hydroxyapatite-zirconia-silver layer in pig's tibiae

Trincă, Lucia Carmen; Mareci, Daniel; Lozano-Gorrı́n, A.D.; Izquierdo, Javier; Burtan, L. C.; Motrescu, Iuliana; Vulpe, V.; Pavel, Geta; Strungaru, Ștefan-Adrian; Stoleriu, Iulian; Strat, Aurel Lulu; Solcan, Carmen

doi:10.1016/j.apsusc.2019.05.003

Cited by 15 publications

(8 citation statements)

References 59 publications

(50 reference statements)

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“…Since then, several materials have been investigated and not only pure metals were explored but also metals, ceramics modified with biocompatible coatings, and polymers. Some examples include calcium phosphate and hydroxyapatite (HA) [ 3 , 4 , 5 , 6 ]; some metal alloys, such as nickel-titanium (NiTi), stainless steel, and Vitallium (a cobalt-chrome alloy composed of 65% Co, 30% Cr, and 5% Mo) [ 7 ]; ceramic cements like alumina (Al 2 O 3 ), spinel (MgAl 2 O 4 ) and zirconia (ZrO 2 ) [ 4 ]; and polymers such as sulfonated poly(ether-ether-ketone) (PEEK), poly(methylmethacrylate) (PMMA), and polylactic acid (PLA) [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Polymer-Infiltrated Ceramic Network with Biocompatible Adhesive to Potentiate Dental Implant Applications

et al. 2021

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The aim of this work was to prepare and characterize polymer–ceramic composite material for dental applications, which must resist fracture and wear under extreme forces. It must also be compatible with the hostile environment of the oral cavity. The most common restorative and biocompatible copolymer, 2,2-bis(p-(2′-2-hydroxy-3′-methacryloxypropoxy)phenyl)propane and triethyleneglycol dimethacrylate, was combined with 3D-printed yttria-stabilized tetragonal zirconia scaffolds with a 50% infill. The proper scaffold deposition and morphology of samples with 50% zirconia infill were studied by means of X-ray computed microtomography and scanning electron microscopy. Samples that were infiltrated with copolymer were observed under compression stress, and the structure’s failure was recorded using an Infrared Vic 2DTM camera, in comparison with empty scaffolds. The biocompatibility of the composite material was ascertained with an MG-63 cell viability assay. The microtomography proves the homogeneous distribution of pores throughout the whole sample, whereas the presence of the biocompatible copolymer among the ceramic filaments, referred to as a polymer-infiltrated ceramic network (PICN), results in a safety “damper”, preventing crack propagation and securing the desired material flexibility, as observed by an infrared camera in real time. The study represents a challenge for future dental implant applications, demonstrating that it is possible to combine the fast robocasting of ceramic paste and covalent bonding of polymer adhesive for hybrid material stabilization.

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Section: Introductionmentioning

confidence: 99%

3D-Printed Polymer-Infiltrated Ceramic Network with Biocompatible Adhesive to Potentiate Dental Implant Applications

et al. 2021

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“…Titanium substrates modified with such hybrid coatings exhibited strong bactericidal effects due to the synergistic activity of the latter two components [ 313 ]. Even if nanostructured coatings of HAp, zirconium oxide and nanosilver proved to decrease the corrosion resistance of zirconium/titanium alloy, they showed superior osteoconductive ability and enhanced the in vivo osseointegration of as-modified implants [ 314 , 315 ].…”

Section: Silver Nanoparticles For Tissue Engineeringmentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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“…Although HA coatings are chemically stable and show long-term survival, there are several concerns about their load bearing performance [6]. Possible ways to solve this lack of mechanical stability could be inter-growing the HA with TMOs such as zirconia [7] and alumina [8] or be constituting composites with graphene [9]. Moreover, doping HA with other bioactive ions, such as Ag + [6] and Mg 2+ [10], could introduce interesting bactericide and other therapeutic effects (Figure 1).…”

Section: Titanium Oxidementioning

confidence: 99%

Atomic Resolution Electron Microscopy: A Key Tool for Understanding the Activity of Nano-Oxides for Biomedical Applications

et al. 2021

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Transition metal oxides constitute one of the most fruitful sources of materials with continuously increasing potential applications prompted by the expectations derived from the reduction of the particle size. The recent advances in transmission electron microscopy, because of the development of lenses, have made it possible to reach atomic resolution, which can provide answers regarding the performance of the transition metal nano-oxides. This critical information is related not only to the ability to study their microstructural characteristics but also their local composition and the oxidation state of the transition metal. Exploring these features is a well-known task in nano-oxides for energy and electronic technologies, but they are not so commonly used for elucidating the activity of these oxides for biomedical applications. Nevertheless, the identification at the atomic level of a certain dopant or the unambiguous determination of the oxidation state of a transition metal in a nano-oxide can be important questions to be answered in a certain biomedical application. In this work, we provide several examples in transition metal nano-oxides to show how atomic-resolution electron microscopy can be a key tool for its understanding.

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Osseointegration evaluation of ZrTi alloys with hydroxyapatite-zirconia-silver layer in pig's tibiae

Cited by 15 publications

References 59 publications

3D-Printed Polymer-Infiltrated Ceramic Network with Biocompatible Adhesive to Potentiate Dental Implant Applications

3D-Printed Polymer-Infiltrated Ceramic Network with Biocompatible Adhesive to Potentiate Dental Implant Applications

An Updated Review on Silver Nanoparticles in Biomedicine

Atomic Resolution Electron Microscopy: A Key Tool for Understanding the Activity of Nano-Oxides for Biomedical Applications

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