Osseointegration – communication of cells

Terheyden, Hendrik; Lang, Niklaus P.; Bierbaum, Susanne; Stadlinger, Bernd

doi:10.1111/j.1600-0501.2011.02327.x

Cited by 227 publications

(253 citation statements)

References 65 publications

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“…Upon implant placement, proteins from the blood and the surrounding bone matrix are adsorbed onto the surface of the biomaterial 27) whereby adhesion proteins like fibronectin, fibrinogen and vitronectin can subsequently mediate further cellular binding and interaction 28) . Platelets are one of the first of the cellular mediators of the ensuing repair process to reach the implant site where the platelets attach to adsorbed adhesion proteins such as fibrinogen through their integrin α IIbβ3 surface receptor, thus forming a monolayer.…”

Section: Discussionmentioning

confidence: 99%

Titanium surface hydrophilicity enhances platelet activation

2014

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Titanium implant surface modification is a key strategy used to enhance osseointegration. Platelets are the first cells that interact with the implant surface whereupon they release a wide array of proteins that influence the subsequent healing process. This study therefore investigated the effect of titanium surface modification on the attachment and activation of human platelets. The surface characteristics of three titanium surfaces: smooth (SMO), micro-rough (SLA) and hydrophilic micro-rough (SLActive) and the subsequent attachment and activation of platelets following exposure to these surfaces were determined. The SLActive surface showed the presence of significant nanoscale topographical features. While attached platelets appeared to be morphologically similar, significantly fewer platelets attached to the SLActive surface compared to both the SMO and SLA surfaces. The SLActive surface however induced the release of the higher levels of chemokines β-thromboglobulin and platelet factor 4 from platelets. This study shows that titanium surface topography and chemistry have a significant effect on platelet activation and chemokine release.

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Section: Discussionmentioning

confidence: 99%

Titanium surface hydrophilicity enhances platelet activation

2014

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“…The late phase of inflammation, assist the formation of granulation tissue and release growth factors that stimulate fibroblasts. Granulation tissue is rich in cells and the collagen matrix provides a suitable environment for cell proliferation and increase the vascularisation prior to bone formation [12]. However, if pro-inflammatory cytokines continue to be expressed, the inflammatory period can be extended, as was the case for the patient with several surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

A Case of Failed Vertical Augmentation of a Post-Traumatic Mandibular Defect by Distraction Osteogenesis

Rosén

Weiner

2017

JDHODT

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One trauma case is presented. An ice-hockey puck fractured the mandible and caused major soft tissue damages including the periosteum. After healing the alveolar ridge was lost and a reconstruction had to be made. Distraction osteogenesis (DO) treatment was conducted but a postoperative infection disrupted the bone distraction phase and eventually synthetic bone matrix had to be used. The patient experienced considerable problems post-DO surgery. However, after three surgical procedures dental implants were inserted. DO is a reliable treatment in patients where vertical bone height is missing, and healthy tissue is present. However, when the periosteum is damaged or postoperative infection is present, DO is disturbed and in this case a synthetic bone matrix had to be employed. One and a half years later a prosthetic bridge has been installed giving delayed but satisfactory result.

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“…The sequence of events that occur in relation to the healing of the peri-implant soft tissue are as follows [55,[101][102][103]]:…”

Section: Peri-implant Soft Tissue Healingmentioning

confidence: 99%

“…The fibrin coagulum is infiltrated by vascular units, originating from the adjacent recipient alveolar bone and periosteum, and fibroblast-like cells which result in the formation of granulation tissue [102].…”

Section: Peri-implant Hard Tissue Healingmentioning

confidence: 99%