Osseointegration- A Review

Vaidya, Prutha; Mahale, Swapna; Kale, Sunila; Patil, Agraja Ganpat

doi:10.9790/0853-1601014548

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…Vascular endothelial cells are the inner lining of the bone vascular system, which provides nutrients and metabolites necessary for osteogenesis (including the migration, proliferation and differentiation of osteogenesis‐related cells), aiding in bone regeneration (Zhou et al., 2020 ). After the mechanical damage caused by the implantation procedure, there will be temporary hypoxia in the peri‐implant region owing to vascular disruption and oxygen consumption by metabolically active cells (Kumar et al., 2021 ; Vaidya et al., 2017 ; Zou et al., 2011 ). During hypoxia, macrophages secret VEGF, which promotes the proliferation, migration and angiogenesis of VECs (Guo et al., 2017 ).…”

Section: Peri‐implant Cell Function and Mitochondrial Regulationmentioning

confidence: 99%

The role of mitochondria in the peri‐implant microenvironment

Zhang

Sun

Zhou

et al. 2023

Experimental Physiology

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New Findings What is the topic of this review?In this review, we consider the key role of mitochondria in the peri‐implant milieu, including the regulation of mitochondrial reactive oxygen species and mitochondrial metabolism in angiogenesis, the polarization of macrophage immune responses, and bone formation and bone resorption during osseointegration. What advances does it highlight?Mitochondria contribute to the behaviours of peri‐implant cell lines based on metabolic and reactive oxygen species signalling modulations, which will contribute to the research field and the development of new treatment strategies for improving implant success. Abstract Osseointegration is a dynamic biological process in the local microenvironment adjacent to a bone implant, which is crucial for implant performance and success of the implant surgery. Recently, the role of mitochondria in the peri‐implant microenvironment during osseointegration has gained much attention. Mitochondrial regulation has been verified to be essential for cellular events in osseointegration and as a therapeutic target for peri‐implant diseases in the peri‐implant microenvironment. In this review, we summarize our current knowledge of the key role of mitochondria in the peri‐implant milieu, including the regulation of mitochondrial reactive oxygen species and mitochondrial metabolism in angiogenesis, the polarization of macrophage immune responses, and bone formation and resorption during osseointegration, which will contribute to the research field and the development of new treatment strategies to improve implant success. In addition, we indicate limitations in our current understanding of the regulation of mitochondria in osseointegration and suggest topics for further study.

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Section: Peri‐implant Cell Function and Mitochondrial Regulationmentioning

confidence: 99%

The role of mitochondria in the peri‐implant microenvironment

Zhang

Sun

Zhou

et al. 2023

Experimental Physiology

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“…Usage of these basic techniques opens a wide scope to develop and optimize different implant materials. The history of osseointegration goes back several centuries, but critical research on this process began only in the 20th century [ 218 ]. In 1952, the Swedish orthopedist Per-Ingvar Brånemark, who was researching blood circulation, accidentally discovered that titanium had integrated into the tissue of a rabbit that had a titanium tube implanted in its bone [ 219 , 220 ] discovering the phenomenon, Brånemark began investigating osseointegration in order to develop durable orthopedic implants [ 219 ].…”

Section: Implantsmentioning

confidence: 99%

Nanotechnology for Dentistry: Prospects and Applications

Glowacka-Sobotta

Ziental

Czarczyńska-Goślińska

et al. 2023

Nanomaterials

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In the XXI century, application of nanostructures in oral medicine has become common. In oral medicine, using nanostructures for the treatment of dental caries constitutes a great challenge. There are extensive studies on the implementation of nanomaterials to dental composites in order to improve their properties, e.g., their adhesive strength. Moreover, nanostructures are helpful in dental implant applications as well as in maxillofacial surgery for accelerated healing, promoting osseointegration, and others. Dental personal care products are an important part of oral medicine where nanomaterials are increasingly used, e.g., toothpaste for hypersensitivity. Nowadays, nanoparticles such as macrocycles are used in different formulations for early cancer diagnosis in the oral area. Cancer of the oral cavity—human squamous carcinoma—is the sixth leading cause of death. Detection in the early stage offers the best chance at total cure. Along with diagnosis, macrocycles are used for photodynamic mechanism-based treatments, which possess many advantages, such as protecting healthy tissues and producing good cosmetic results. Application of nanostructures in medicine carries potential risks, like long-term influence of toxicity on body, which need to be studied further. The introduction and development of nanotechnologies and nanomaterials are no longer part of a hypothetical future, but an increasingly important element of today’s medicine.

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“…After the surgical placement of the implant, wound healing and osseointegration occur in three phases: (1) the inflammatory phase, wherein primary healing occurs through cellular and vascular events, (2) the proliferative phase, where neovascularization occurs, and the woven bone is formed, and (3) the maturation phase, in which ossification of the woven bone occurs. Ossification, which is called remodeling and regeneration of the bone, occurs later 4 …”

Section: Introductionmentioning

confidence: 99%

“…Ossification, which is called remodeling and regeneration of the bone, occurs later. 4 The stability of the implant is another essential aspect that determines the permanency of the implant. There are two types of stability: primary stability, which is attained by mechanical locking of the implant with the dense cortical bone, 5 and secondary stability, which is achieved by the remodeling and regeneration of the bone surrounding the implant.…”

Section: Introductionmentioning

confidence: 99%

Use of temporary abutment to assess implant osseointegration before final impression: A case report

Labban

2021

Clinical Case Reports

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In implant dentistry, a temporary abutment, either plastic or metal, also called an implant cylinder, is used to construct a provisional restoration. This provisional restoration can be cemented on or integrated with a temporary abutment for a screw‐retained prosthesis. It can be further used as a diagnostic tool to evaluate esthetics and promote tissue healing around implants. After achieving osseointegration of the implant with the adjacent bone and a proper soft tissue profile, both the temporary abutment and the prosthesis can be replaced with permanent ones. In the present case report, a simple technique using a temporary abutment was utilized for the assessment of implant osseointegration before making the final impression. In this study, we discuss the advantages of this method over other methods. It is impossible to verify the stability of the implant at all stages of implant placement; however, the clinical procedure explained in the case report is easy to apply and provides good results.

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Osseointegration- A Review

Cited by 14 publications

References 6 publications

The role of mitochondria in the peri‐implant microenvironment

The role of mitochondria in the peri‐implant microenvironment

Nanotechnology for Dentistry: Prospects and Applications

Use of temporary abutment to assess implant osseointegration before final impression: A case report

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