Ospiti stranieri di casa Vieusseux nella Firenze di metà Ottocento

Pacini, Monica

doi:10.3280/mer2014-046005

Cited by 3 publications

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“…Pacini honestly indicated the existing limits of his research on cholera, as he did not carry out germ cultures [44].…”

Section: Therapy Of Patients In the Terminal Phasementioning

confidence: 99%

The enigma of Pacini’s Vibrio cholerae discovery

Carboni

2021

Journal of Medical Microbiology

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During the 1854 cholera outbreak in Florence, Italy, Filippo Pacini documented that the cause of the infection was a bacterium. This conclusion was also independently reached by John Snow during the 1854 cholera outbreak in London. By using an epidemiological method, Snow found that the infection spread through a polluted water network. Snow identified a water pump as the source of the disease. After removing the infected handle of this pump, the cases of cholera rapidly began to decrease. A microscopic examination of the water showed organic impurities but no bacteria. This discovery was ignored during Snow’s lifetime. In contrast, through microscopy during the autopsies of cholera victims, Pacini observed that the disruption of their intestinal mucosa was closely associated with millions of the bacteria that he called Vibrio cholerae . Via histological techniques, Pacini detected that intestinal mucosa reabsorption dysfunction was the cause of debilitating diarrhoea, vomiting, severe dehydration and death. Nevertheless, his discovery of Vibrio cholerae was ignored during Pacini’s lifetime. A survey of Pacini’s autographic manuscripts suggests that Pacini and Snow may have shared mutual knowledge within their respective seminal papers. This survey also facilitates, for the first time, the creation of maps that illustrate the worldwide distribution of Pacini’s cholera papers from 1854 to 1881. The consistent neglect of Pacini’s discovery remains a true enigma.

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“…Pacini honestly indicated the existing limits of his research on cholera, as he did not carry out germ cultures [44].…”

Section: Therapy Of Patients In the Terminal Phasementioning

confidence: 99%

The enigma of Pacini’s Vibrio cholerae discovery

Carboni

2021

Journal of Medical Microbiology

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“…In 1835, Agostino Bassi identified Beauveria bassiana as the microbial origin of the silkworm disease called muscardine [2]. In 1854, Filippo Pacini isolated and identified the Vibrio cholerae as a pathogen [3]; meanwhile, Casimir Davaine discovered the anthrax bacillus [4]. These discoveries propelled microbiology forward, driven by the efforts of figures like Robert Koch [5] and Louis Pasteur [6].…”

Section: Introductionmentioning

confidence: 99%

Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target

Hervin,

Roy,

Agrofoglio

2023

Molecules

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The emergence of Multidrug Resistance (MDR) strains of bacteria has accelerated the search for new antibacterials. The specific bacterial peptidoglycan biosynthetic pathway represents opportunities for the development of novel antibacterial agents. Among the enzymes involved, Mur ligases, described herein, and especially the amide ligases MurC-F are key targets for the discovery of multi-inhibitors, as they share common active sites and structural features.

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L’orientaliste et le mondain. Sociabilités aristocratiques transnationales en Italie (Florence, années 1870)

Bossaert¹

2018

mefrim

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Ospiti stranieri di casa Vieusseux nella Firenze di metà Ottocento

Cited by 3 publications

References 0 publications

The enigma of Pacini’s Vibrio cholerae discovery

The enigma of Pacini’s Vibrio cholerae discovery

Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target

L’orientaliste et le mondain. Sociabilités aristocratiques transnationales en Italie (Florence, années 1870)

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