OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway

Luo, Xiaoyan; Li, Qun; Yang, Huan; Tan, Qi; Gan, Liqiang; Ren, Faliang; Wang, Hua

doi:10.1186/s10020-018-0025-6

Cited by 24 publications

(25 citation statements)

References 42 publications

(42 reference statements)

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“…The verified results were consistent with the RNA sequencing results. In agreement with literature reports, SOCS3, 35 , 36 OSM, 37 , 38 IL-6, 5 , 36 IL-10, 39 CXCL-1 5 and CXCL-8 17 increased significantly, so inflammatory factors-mediated injury is an important factor of BLI. OSMR and CDNK1A are the genes related to inflammatory response, cell growth and proliferation and involved in the JAK-STAT3 signaling pathway.…”

Section: Discussionsupporting

confidence: 92%

“…OSMR and CDNK1A are the genes related to inflammatory response, cell growth and proliferation and involved in the JAK-STAT3 signaling pathway. 38 In accordance with references 40 , 41 , 42 , we also found that the expressions of FASLG and CD14 increased significantly, suggesting that it may be involved in the immune response in BLI. This may provide a new tool to find useful targets for monitoring, evaluating, even weakening the overwhelming inflammatory response of patients with blast injury.…”

Section: Discussionsupporting

confidence: 90%

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Global gene expression profiling of blast lung injury of goats exposed to shock wave

Wang

Zhang

Gao³

et al. 2020

Chinese Journal of Traumatology

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Purpose Blast lung injury (BLI) is the most common damage resulted from explosion-derived shock wave in military, terrorism and industrial accidents. However, the molecular mechanisms underlying BLI induced by shock wave are still unclear. Methods In this study, a goat BLI model was established by a fuel air explosive power. The key genes involved in were identified. The goats of the experimental group were fixed on the edge of the explosion cloud, while the goats of the control group were 3 km far away from the explosive environment. After successful modeling for 24 h, all the goats were sacrificed and the lung tissue was harvested for histopathological observation and RNA sequencing. Gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) analysis were performed to identify the main enriched biological functions of differentially expressed genes (DEGs). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the consistency of gene expression. Results Of the sampled goat lungs, 895 genes were identified to be significantly differentially expressed, and they were involved in 52 significantly enriched GO categories. KEGG analysis revealed that DEGs were highly enriched in 26 pathways, such as cytokine-cytokine receptor interaction, antifolate resistance, arachidonic acid metabolism, amoebiasis and bile secretion, JAK-STAT, and IL-17 signaling pathway. Furthermore, 15 key DEGs involved in the biological processes of BLI were confirmed by qRT-PCR, and the results were consistent with RNA sequencing. Conclusion Gene expression profiling provide a better understanding of the molecular mechanisms of BLI, which will help to set strategy for treating lung injury and preventing secondary lung injury induced by shock wave.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Global gene expression profiling of blast lung injury of goats exposed to shock wave

Wang

Zhang

Gao³

et al. 2020

Chinese Journal of Traumatology

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“…However, in diabetic skin with an impaired function of keratinocytes, the suppressed innate immune response and reduced immune infiltrates in the dermis may result in disrupted skin homeostasis. However, the expressions of these innate immune-related genes in keratinocytes differ among various skin conditions such as atopic dermatitis and autoimmune urticaria [55,56], and the expressions of these genes in diabetic keratinocytes have not been reported. Further investigation is needed in order to confirm our current findings.…”

Section: Discussionmentioning

confidence: 99%

Deduction of Novel Genes Potentially Involved in Keratinocytes of Type 2 Diabetes Using Next-Generation Sequencing and Bioinformatics Approaches

Lin

Chang

Chen

et al. 2019

JCM

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Keratinocytes constitute the major cell type of epidermis, which participates in re-epithelialization during wound repair and the immune defense response to pathogens. The aim of the current study was to explore the differentially expressed genes and novel microRNA (miRNA) regulations that are potentially involved in diabetic keratinocytes through next-generation sequencing (NGS) and bioinformatics approaches. A total of 420 differentially expressed genes between normal and diabetic keratinocytes were identified, and systematic bioinformatics analyses indicated that these differentially expressed genes were functionally enriched in interferon-alpha signaling, viral defense response, and immune response. Additionally, the potential miR-340-3p-DTX3L interaction that has been systematically validated in miRNA prediction databases was proposed to participate in the disrupted skin homeostasis, altering the defense and immune response of diabetic skin. The findings may provide new insights into understanding the pathogenesis of epidermal pathologies in diabetic patients and targeting novel molecules to advance diabetic skin care in clinical practice.

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“…Increased expression of OSMR protein and histamine release were also shown in chronic autoimmune urticaria. In addition, OSMR gene silencing in mice led to a decrease in inflammatory cytokines and number of eosinophils [157]. These data indicate that IL-31 or OSMRβ inhibitors (e.g., nemolizumab, vixarelimab) might play a role in the treatment of CSU.…”

Section: Other Possıble Targets For Treatmentmentioning

confidence: 73%

Targeted Therapy for Chronıc Spontaneous Urtıcarıa: Ratıonale and Recent Progress

Giménez‐Arnau

Salman

2020

Drugs

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Chronic spontaneous urticaria (CSU) is characterized by the presence of wheals, angioedema, or both for at least 6 weeks. It may persist for a long time-up to 50% of the patients have been reported to be symptomatic 5 years after the onset. Some patients can suffer more than one episode of CSU during their lifetime. Considering the recurrences, disabling symptoms, and significant impact on quality of life, proper and effective treatment of CSU is critical. The use of antihistamines (AHs) is still the mainstay of treatment. However, given the low rates of response to AHs (38.6% and 63.2% to standard doses and higher doses, respectively), the complete control of symptoms seems difficult to attain. The use of omalizumab for CSU has been a major breakthrough in the care of patients with CSU. However, the partial response and lack of response to omalizumab in a subgroup of patients, as high as 70% in some studies, make the development of alternative treatments desirable. Ever-increasing knowledge on the pathogenesis is making new target molecules available and enabling drug development for CSU. In addition to drug repurposing as in anti-IL-4/13, IL-5, and IL-17 antibodies, novel targeted therapy options such as ligelizumab and Bruton's tyrosine kinase inhibitors are currently undergoing clinical trials and will be available in the near future. This article reviews the current challenges in the treatment of CSU, the pathogenesis and potential target molecules, and the rationale for novel treatments and their rapidly developing status.

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OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway

Cited by 24 publications

References 42 publications

Global gene expression profiling of blast lung injury of goats exposed to shock wave

Global gene expression profiling of blast lung injury of goats exposed to shock wave

Deduction of Novel Genes Potentially Involved in Keratinocytes of Type 2 Diabetes Using Next-Generation Sequencing and Bioinformatics Approaches

Targeted Therapy for Chronıc Spontaneous Urtıcarıa: Ratıonale and Recent Progress

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