Osmotic regulation of neuronal activity: a new role for taurine and glial cells in a hypothalamic neuroendocrine structure

Hussy, Nicolas; Deleuze, Charlotte; Desarménien, Michel G.; Moos, Françoise

doi:10.1016/s0301-0082(99)00071-4

Cited by 180 publications

(146 citation statements)

References 143 publications

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…A 10-fold increase compared with vehicle, and five-fold compared with all other drugtreatments was seen. A likely explanation for this comes from the knowledge that the supraoptic nucleus is sensitive to osmotic balance (see Hussy et al (2000) for a review) and the injection of a large number of Li þ ions may disrupt this balance. Despite a trend towards an increase following fluoxetine treatment, as previously reported by immunohistochemical studies (Torres et al, 1998), this did not reach significance compared with vehicle in the present study (Table 2).…”

Section: Most Robust Increase In C-fos Mrnamentioning

confidence: 99%

Comparison of Alterations in c-fos and Egr-1 (zif268) Expression Throughout the Rat Brain Following Acute Administration of Different Classes of Antidepressant Compounds

Slattery

Morrow²,

Hudson

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

The majority of immediate-early gene (IEG) studies focus on a few key brain regions associated with the class of psychoactive compound being studied. Recently, using a meta-analysis of the c-fos literature, we demonstrated the utility of c-fos profiling to classify such compounds. The present study examined acute delivery of a range of antidepressant classes; fluoxetine, imipramine, LiCl, and mirtazapine. The dual aims were to study the IEG profiles of these varying classes of antidepressants throughout the rat brain and to compare the utility of c-fos or Egr-1 as IEGs to classify clinically efficacious antidepressants. All antidepressants increased c-fos mRNA in the central amygdala, as previously shown, while c-fos was also increased in the anterior insular cortex and significantly decreased within the septum. Although acute antidepressant administration altered c-fos expression in a number of brain regions, Egr-1 expression was only significantly altered in the central amygdala, suggesting that Egr-1 may not be as useful a marker to investigate acute antidepressant treatment. The fact that these drugs, including the previously unclassified antidepressant mirtazapine, share a number of common loci of activation, which are implicated by human and animal studies in depression, adds further support to the use of IEG mapping to classify psychoactive compounds.

show abstract

Section: Most Robust Increase In C-fos Mrnamentioning

confidence: 99%

Comparison of Alterations in c-fos and Egr-1 (zif268) Expression Throughout the Rat Brain Following Acute Administration of Different Classes of Antidepressant Compounds

Slattery

Morrow²,

Hudson

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…It should be stressed, however, that the impact of cell-volume perturbations on cellular physiology is not exclusively negative. Thus cell volume serves as a physiological modulator of cellular functions in hepatocytes, epithelial cells, brain glial cells, and a variety of migrating cells (20,21,(23)(24)(25)29). In the kidneys, the transepithelial transport of electrolytes across the basolateral and apical membranes of secretory cells is thought to be coordinated by changes in cellular volume that strongly regulate the activity of volume-sensitive K ϩ and Cl Ϫ channels as well as ion carriers, including the Na…”

mentioning

confidence: 99%

Activation of P2Y receptors causes strong and persistent shrinkage of C11-MDCK renal epithelial cells

Кольцова

Platonova

Максимов

et al. 2011

American Journal of Physiology-Cell Physiology

View full text Add to dashboard Cite

show abstract

“…Several studies demonstrated that astrocytes in the SON and PVN also have important roles in regulating osmotic pressure (2). Under hypotonic pressure, taurine, an amino acid that is abundant in astrocytes (3), is released upon astrocyte swelling and activates the glycine receptors on MNCs in the SON and PVN to inhibit the activation of MNCs and VP release (2).…”

Section: Introductionmentioning

confidence: 99%

Involvement of connexin43 in the acute hyperosmotic stimulus-induced synthesis and release of vasopressin in the supraoptic nucleus of rats

Jiang

Wang

et al. 2014

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. There is evidence that astroglial connexin43 (Cx43) in the supraoptic nucleus (SON) is required for the hyperosmolarity-induced increase in Fos protein expression in magnocellular neurosecretory cells (MNCs). In the present study, the role of astroglial Cx43 in the synthesis and release of vasopressin (VP) by MNCs in the SON subjected to hyperosmotic stimulus was examined. The results revealed that the VP levels in the SON and plasma were increased following acute hyperosmotic stimulus. Treatment of MNCs with Cx43-specific antisense oligodeoxynucleotides (ASODN), which temporarily reduced Cx43 protein production, limited the VP synthesis and release induced by a hyperosmotic stimulus. Similarly, the addition of gap junction and Cx43 hemichannel blockers also attenuated the VP synthesis and release induced by an acute hyperosmotic stimulus. A high extracellular [Ca 2+ ]( [Ca 2+ ] o ) has been demonstrated to reduce the gap junction activity or opening probability of Cx54 hemichannels. Notably, it was identified that high [Ca 2+ ] o attenuated the VP synthesis and release induced by acute hyperosmotic stimulus, while low [Ca 2+ ] o had a weak or no effect. These results suggested that Cx43 participates in the VP synthesis and release induced by hyperosmotic stimulation in the SON.

show abstract

Osmotic regulation of neuronal activity: a new role for taurine and glial cells in a hypothalamic neuroendocrine structure

Cited by 180 publications

References 143 publications

Comparison of Alterations in c-fos and Egr-1 (zif268) Expression Throughout the Rat Brain Following Acute Administration of Different Classes of Antidepressant Compounds

Comparison of Alterations in c-fos and Egr-1 (zif268) Expression Throughout the Rat Brain Following Acute Administration of Different Classes of Antidepressant Compounds

Activation of P2Y receptors causes strong and persistent shrinkage of C11-MDCK renal epithelial cells

Involvement of connexin43 in the acute hyperosmotic stimulus-induced synthesis and release of vasopressin in the supraoptic nucleus of rats

Contact Info

Product

Resources

About