Osmoregulation in the mammalian kidney: The role of organic osmolytes

Grunewald, R. Willi; Kinne, Rolf K. H.

doi:10.1002/(sici)1097-010x(19990601)283:7<708::aid-jez9>3.0.co;2-v

Cited by 27 publications

(11 citation statements)

References 106 publications

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“…In the brain for example, the overall contribution of taurine release to RVD is about 35%, but taurine is the osmolyte most sensitive to alterations of the external osmolarity (reviewed in [217]). In the kidney however, organic osmolyte efflux dominates the response to hypoosmotic challenges (reviewed in [103] [218]) and possibly stretch-activated K + channels (reviewed in [159,160,161,162,163,164,220,234,247]), as well as K + /Cl --symport (reviewed in [167]) or the parallel activation of K + /H + and HCO 3 -/Cl -exchangers (reviewed in [159]), mediate K + efflux.…”

Section: Mechanisms For Rvd In Mammalian Cellsmentioning

confidence: 99%

Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells*

Fürst

Gschwentner

Ritter

et al. 2002

Pflügers Arch - Eur J Physiol

105

119

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Section: Mechanisms For Rvd In Mammalian Cellsmentioning

confidence: 99%

Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells*

Fürst

Gschwentner

Ritter

et al. 2002

Pflügers Arch - Eur J Physiol

105

119

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“…However, in the renal medulla interstitial concentrations of osmotically active substances are generally much higher compared with those in other compartments of the body, and fluctuate considerably during the transition from diuresis to antidiuresis and vice versa. To survive large changes in tonicity, the cells of the renal medulla accumulate organic osmolytes (polyhydric alcohols, amino acids and polyamines), which under hypotonic stress are released together with inorganic ions [1,13,15]. In TALH cells two organic osmolytes, sorbitol and betaine, have been found to be involved in osmotic regulation [9,14].…”

Section: Introductionmentioning

confidence: 99%

Calcium-induced calcium release participates in cell volume regulation of rabbit TALH cells

Tinel

Kinne-Saffran

Kinne

2002

Pflugers Arch - Eur J Physiol

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Changes of cell volume and intracellular calcium concentration ([Ca(2+)](i)) in immortalized thick ascending limb of Henle's loop (TALH) cells were monitored using confocal laser scanning microscopy and fura-2 fluorescence, respectively. Reduction of the extracellular osmolarity from 600 to 300 mosmol/l induced cell swelling followed by regulatory volume decrease (RVD). Simultaneously, the [Ca(2+)](i) increased transiently. The calcium rise was not observed in calcium-free solution or in the presence of nifedipine, indicating that the change was, in the first place, due to the activation of a calcium influx. Application of ATP or caffeine in isotonic solutions increased transiently the [Ca(2+)](i) which revealed the existence of stores in TALH cells sensitive to inositol-1,4,5 trisphosphate (IP(3)) and ryanodine. To examine the possibility that the calcium influx might induce calcium release, manganese quenching experiments were performed. In hypotonic calcium-free solutions, the decay of the calcium-insensitive and calcium-sensitive fluorescence occurred simultaneously. In the presence of extracellular calcium however, the calcium-sensitive wavelength revealed initial calcium influx followed by a calcium release from intracellular stores. Thus, the calcium influx was a prerequisite for the calcium release. We conclude that calcium-induced calcium release participates in global calcium signalling during RVD of TALH cells.

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“…One of the major places for organic osmolyte accumulation is the renal medulla, where accumulation occurs because of a broad range of extracellular osmolalities exceeding normal osmolality (for review see Beck et al 1985;Bagnasco et al 1986;Yancey and Burg 1989;Garcia-Perez and Burg 1991;Kinne et al 1993;Kinne 1993;Kinne et al 1995;Kinne 1998;Grunewald and Kinne 1999;Kinne et al 2001) in particular in the direction of hyperosmolality (Grunewald et al 1993a;Grunewald et al 1994;Handler and Kwon 2001). Also chondrocytes (de Angelis et al 1999;Hall and Bush 2001) encounter hyperosmolality in the extracellular space because of the high concentration of fixed charges in the mucopolysaccharides in which they are embedded.…”

Section: Inorganic and Organic Osmolytesmentioning

confidence: 99%

“…Physiological plasma concentrations of myo-inositol range in mammals from 4.5 mMol/l to 6.6 mMol/l, whereas intracellular concentrations up to 133 mMol/l can be found in rat glial (Strange et al 1991) and renal medullary cells (Bagnasco et al 1986;Nakanishi et al 1988;Wirthensohn et al 1989;Yancey and Burg 1989;Garcia-Perez and Burg 1991;Sizeland et al 1993;Grunewald et al 1995;Grunewald and Kinne 1999;Handler and Kwon 2001). This large concentration difference suggests active uptake of myo-inositol into these cells.…”

Section: Na + -Myo-inositol Symportmentioning

confidence: 99%

Cell volume regulation: osmolytes, osmolyte transport, and signal transduction

Wehner

Olsen

Tinel³

et al.

Reviews of Physiology, Biochemistry and Pharmacology

323

333

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In recent years, it has become evident that the volume of a given cell is an important factor not only in defining its intracellular osmolality and its shape, but also in defining other cellular functions, such as transepithelial transport, cell migration, cell growth, cell death, and the regulation of intracellular metabolism. In addition, besides inorganic osmolytes, the existence of organic osmolytes in cells has been discovered. Osmolyte transport systems-channels and carriers alike-have been identified and characterized at a molecular level and also, to a certain extent, the intracellular signals regulating osmolyte movements across the plasma membrane. The current review reflects these developments and focuses on the contributions of inorganic and organic osmolytes and their transport systems in regulatory volume increase (RVI) and regulatory volume decrease (RVD) in a variety of cells. Furthermore, the current knowledge on signal transduction in volume regulation is compiled, revealing an astonishing diversity in transport systems, as well as of regulatory signals. The information available indicates the existence of intricate spatial and temporal networks that control cell volume and that we are just beginning to be able to investigate and to understand.

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Osmoregulation in the mammalian kidney: The role of organic osmolytes

Cited by 27 publications

References 106 publications

Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells*

Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells*

Calcium-induced calcium release participates in cell volume regulation of rabbit TALH cells

Cell volume regulation: osmolytes, osmolyte transport, and signal transduction

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