Osmolar Urinary Concentrating Ability and Pyelonephritis in Hospitalized Patients

Kaitz, Alan L.; London, Abram M.

doi:10.1097/00000441-196407000-00002

Cited by 20 publications

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“…183 lyzed at freezing points higher than -0.36"C, corresponding to an osmolality close to 200 mOsm/kg. About half of the urinary osmolality is, however, accounted for by compounds which have no influence on the equilibrium between red cells and urine, urea being of main importance (7,14). Erythrocytes suspended in normal urine, like those in the urine of patients with bleeding from the lower urinary tract, showed incipient lysis below a specific gravity of 1.012-1.010, amounting to more than 80% at a specific gravity of 1.0075-1.0059 (31).…”

Section: Discussionmentioning

confidence: 99%

Persistence of Blood Cells in Urine

Gadeholt

1968

Journal of Internal Medicine

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In clinical work the stability of blood cells in urine is a point of practical importance. Provided bacterial contamination can be avoided, erythrocytes and leucocytes are well preserved in acidic urine of a specific gravity higher than 1.008‐1.011 for at least 24 hours. Whether sterile specimens are kept at room temperature, in a refrigerator, or at 37°C seems unimportant. In alkaline urines, the degree of lysis increases with increasing alkalinity and the duration of time of exposure. Leucocytes are especially susceptible to cytolysis in alkaline environments. If bacterial contamination is present, unreliable results are obtained. A comparative study of the number of erythrocytes and leucocytes excreted in overnight specimens and in specimens collected during 2 hours in the morning, estimated per mm3, and expressed as excretion rates, revealed differences which can probably be accounted for mainly by the random variability of haemocytometer counts.

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Section: Discussionmentioning

confidence: 99%

Persistence of Blood Cells in Urine

Gadeholt

1968

Journal of Internal Medicine

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“…Reduction of urinary concentrating ability is frequently reported in urinary tract infection (5, 9,10,17,22) and is considered an early sign of pyelonephritis. Norden and Tuttle (17) found that ten of 24 pregnant women with bacteriuria were unable to concentrate their urine above 700 mOsm/kg, while all subjects in a matched group of pregnant women without bacteriuria could concentrate to above 700 mOsm/kg.…”

Section: Tests 0 Other Gram-negative Rods; -Recurrence Betweenmentioning

confidence: 99%

“…Impairment of urinary concentrating ability is often found among patients with urinary tract infection (3,5,9,10,17,22) and is considered an early sign of pyelonephritis (5,22). In chronic pyelonephritis Kleeman et al (1 1) and Brod et al…”

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confidence: 99%

Studies in Urinary Tract Infections

1970

Journal of Internal Medicine

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Abstract. Maximum urine concentrating ability (MCA) has been determined after the administration of vasopressin tannate in oil and found to be over 800 mOsm/kg in 26 of 28 normal subjects. Subnormal MCA was demonstrated in 93 of 157 bacteriuric women between the ages of 16 and 65. Impairment of MCA was positively correlated with clinical symptoms of acute pyelonephritis (fever and flank pain), and with a raised coli antibody litre. In 115 of the patients MCA was determined again after five to twelve months. In 34% MCA had improved by more than 25%. The assumption that this indicates acute pyelonephritis was supported by the presence of other signs of acute pyelonephritis in most of these patients in contrast to the patients who maintained a normal MCA during he observation period. It should be noted that not only Gram‐negative rods, but also coagulasenegative staphylococci, may cause acute pyelonephritis. The recurrence rate was nearly the same in patients with normal and in patients with impaired MCA before treatment, but it was significantly higher among patients in whom MCA remained low or deteriorated during the observation period than in patients whose MCA remained normal or showed improvement.

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Clinical Application of Cryoscopy

Haraway¹,

Becker²

1968

JAMA

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Osmolar Urinary Concentrating Ability and Pyelonephritis in Hospitalized Patients

Cited by 20 publications

References 0 publications

Persistence of Blood Cells in Urine

Persistence of Blood Cells in Urine

Studies in Urinary Tract Infections

Clinical Application of Cryoscopy

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