Osmolal Gap in Hemodialyzed Uremic Patients

Griveas, Ioannis; Gompou, Athina; Kyritsis, Ilias; Papatheodorou, Georgios; Agroyannis, Ioannis; Tsakoniatis, Manolis; Kapeleris, Evaggelos; Vrachnes, Sotiris

doi:10.1111/j.1525-1594.2011.01293.x

Cited by 9 publications

(8 citation statements)

References 12 publications

(29 reference statements)

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“…The elevated OG in CKD likely results from retention of unidentified solutes. 5 Our finding can be especially of value for patients with earlier stages of CKD when standard estimation equations for GFR (Cockcroft-Gault and MDRD) do not perform well. 7 OG has been shown to be normal in patients with acute renal failure.…”

Section: Discussionmentioning

confidence: 74%

“…4,5 OG was elevated in these patient populations. [3][4][5] Our study adds to the literature in that we described and analyzed OG in different stages of CKD which to our knowledge has not been previously studied. The elevated OG in CKD likely results from retention of unidentified solutes.…”

Section: Discussionmentioning

confidence: 90%

“…4 A more recent adult study of those on maintenance HD found similar results of increased OG pre-HD that was reduced after HD treatment. 5 However, there is a lack of data on OG in earlier stages of CKD as well as limited data of only one study 5 on OG in adults on maintenance HD. This study has two objectives.…”

Section: Introductionmentioning

confidence: 99%

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Changes in osmol gap in chronic kidney disease: an exploratory study

et al. 2013

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 90%

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Changes in osmol gap in chronic kidney disease: an exploratory study

et al. 2013

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“…The difference between the measured and calculated osmolalities is referred to as the osmolar gap, and is typically <10 mOsm/Kg in normal circumstances. The osmolar gap is frequently higher in HD patients, suggesting the presence of additional osmotically active molecules, and tends to close somewhat during the HD session …”

Section: Measurement Of Plasma Osmolalitymentioning

confidence: 99%

Osmolality and blood pressure stability during hemodialysis

Singh

Causland

2017

Seminars in Dialysis

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Homeostatic regulation of plasma osmolality (POsm) is critical for normal cellular function in humans. Arginine vasopressin (AVP) is the major hormone responsible for the maintenance of POsm and acts to promote renal water retention in conditions of increased POsm. However, AVP also exerts pressor effects, and its release can be stimulated by the development of effective arterial blood volume depletion. Patients with end-stage renal disease on hemodialysis, particularly those with minimal or no residual renal function, have impaired ability to regulate water retention in response to AVP. While hemodialysis can assist with this task, patients are subject to relatively rapid shifts in volume and electrolytes during the procedure. This can result in the development of transient osmotic gradients that lead to the movement of water from the extracellular to the intracellular space. Hypotension may result – both as a consequence of water movement out of the intravascular compartment, but also from impaired AVP release and inadequate vascular tone. In this review we explore the evidence for POsm changes during hemodialysis, associations with adverse outcomes, and methods to minimize the rapidity of changes in POsm in an effort to reduce patient symptoms and minimize intra-dialytic hypotension.

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“…Ioannis Griveas et al. of the Military Hospital of Athens, Athens, Greece evaluated the measured and calculated osmolality and the osmolal gap in 24 hemodialyzed uremic patients, pre‐ and posthemodialysis (HD), and compared these with 22 healthy subjects (controls). The measured osmolality in patients is significantly higher pre‐ and post‐HD in comparison to that of controls, but post‐HD is significantly lower than pre‐HD.…”

Section: Renal Support and Dialysismentioning

confidence: 99%

Artificial Organs 2012: A Year in Review

Malchesky¹

2013

Artificial Organs

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In this editor's review, articles published in 2012 are organized by category and briefly summarized. We aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ replacement, recovery, and regeneration. As the official journal of the International Federation for Artificial Organs, the International Faculty for Artificial Organs, and the International Society for Rotary Blood Pumps, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level." Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ replacement, recovery, and regeneration from all over the world. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide such meaningful suggestions to the author's work whether eventually accepted or rejected, and especially to those whose native tongue is not English. Without these excellent and dedicated reviewers, the quality expected from such a journal could not be possible. We also express our special thanks to our publisher, Wiley Periodicals, for their expert attention and support in the production and marketing of Artificial Organs. We look forward to recording further advances in the coming years.

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Osmolal Gap in Hemodialyzed Uremic Patients

Cited by 9 publications

References 12 publications

Changes in osmol gap in chronic kidney disease: an exploratory study

Changes in osmol gap in chronic kidney disease: an exploratory study

Osmolality and blood pressure stability during hemodialysis

Artificial Organs 2012: A Year in Review

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