Osler-Weber-Rendu disease: report of 3 cases in a family

Abstract

Osler-Weber-Rendu disease, also referred to as hereditary haemorrhagic telangiectasia, is a genetic disease, an autosomal dominant disorder characterized by telangiectasias and aneurysms with primary involvement of the mucosa. The reported prevalence of this disease is 1-2 cases per 100 000 population [1]. The disease most commonly occurs in white patients, but has also been described in patients of Asian, African and Arab descent, and occurs with equal frequency and severity in both sexes. The syndrome most often presents by the third decade of life, but may be clinically silent [1,2]. History of epistaxis is noted in 50%-90% of affected patients. Telangiectasias are most commonly seen on nail beds, palms, lips, tongue, ears, face and chest skin. Similar findings on other skin and mucosal surfaces may be seen in this syndrome [3-5]. We describe 3 males from a single family affected with Osler-Weber-Rendu disease. The proband case had been admitted to a general hospital with primary presentation of severe chronic anaemia and with a history of blood transfusion and diagnosis of peptic ulcer. Diagnosis of this syndrome was considered when the patient was referred for dermatologic consultation because there were some telangiectatic vasculae on his earlobe.

Relationship Between Quick of Blood with Arteriovenous Radiocephalic And Brachiocephalic Fistula to Blood Urea Nitrogen (BUN), Creatinine Serum, Neutrophil to Lymphocyte Ratio (NLR), And Hemoglobin in Patients Hemodialysis

“…Shamsadini et al also found similar results in that they studied patients with chronic renal failure who had had a history of hemodialysis for more than one year. In addition to BUN levels which were found to decrease significantly after hemodialysis, serum creatinine levels also declined considerably after hemodialysis (p<0.05) 40 . Serum creatinine levels (serum creatinine, SC) in this study were found to have significantly reduced with levels before hemodialysis of 12.76 ± 3.78 mg/dL and decreased to 4.56 ± 1.68 mg/dL after hemodialysis (p <0.001).…”